2024
DOI: 10.3389/fphar.2024.1396354
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Osteogenic mechanism of chlorogenic acid and its application in clinical practice

Jiayu Shen,
Shichen Zhang,
Jiayu Zhang
et al.

Abstract: Natural polyphenols may have a role in counteracting oxidative stress, which is associated with aging and several bone-related diseases. Chlorogenic acid (CGA) is a naturally occurring polyphenolic compound formed by the esterification of caffeic and quininic acids with osteogenic, antioxidant, and anti-inflammatory properties. This review discusses the potential of CGA to enhance osteogenesis by increasing the osteogenic capacity of mesenchymal stem cells (MSCs), osteoblast survival, proliferation, differenti… Show more

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