Osteogenic properties and anti-osteoporosis activity of calcium hydroxyapatite from Katsuwonus pelamis bone and its water-soluble forms

Aenglong, Chakkapat; Tang, Qing-Juan; Tanasawet, Supita; Klaypradit, Wanwimol; Sukketsiri, Wanida

doi:10.1007/s12562-023-01711-8

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…Ca and P are the dominant components of bone mineral [31], DPD is an important sector of collagen I [32]. The three parameters are the important indicators in evaluating bone loss [32].…”

Section: T-es Reduced Bone Resorption-related Parameters In Serum And...mentioning

confidence: 99%

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Hu,

Wan,

Zhu

et al. 2023

Marine Drugs

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Several sialoglycopeptides were isolated from several fish eggs and exerted anti-osteoporosis effects. However, few papers have explored sialoglycopeptide from tuna eggs (T-ES). Here, a novel T-ES was prepared through extraction with KCl solution and subsequent enzymolysis. Pure T-ES was obtained through DEAE-Sepharose ion exchange chromatography and sephacryl S-300 gel filtration chromatography. The T-ES was composed of 14.07% protein, 73.54% hexose, and 8.28% Neu5Ac, with a molecular weight of 9481 Da. The backbone carbohydrate in the T-ES was →4)-β-D-GlcN-(1→3)-α-D-GalN-(1→3)-β-D-Glc-(1→2)-α-D-Gal-(1→2)-α-D-Gal-(1→3)-α-D-Man-(1→, with two branches of β-D-GlcN-(1→ and α-D-GalN-(1→ linking at o-4 in →2,4)-α-D-Gal-(1→. Neu5Ac in the T-ES was linked to the branch of α-D-GlcN-(1→. A peptide chain, Ala-Asp-Asn-Lys-Ser*-Met-Ile that was connected to the carbohydrate chain through O-glycosylation at the –OH of serine. Furthermore, in vitro data revealed that T-ES could remarkably enhance bone density, bone biomechanical properties, and bone microstructure in SAMP mice. The T-ES elevated serum osteogenesis-related markers and reduced bone resorption-related markers in serum and urine. The present study’s results demonstrated that T-ES, a novel sialoglycopeptide, showed significant anti-osteoporosis effects, which will accelerate the utilization of T-ES as an alternative marine drug or functional food for anti-osteoporosis.

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“…Ca and P are the dominant components of bone mineral [31], DPD is an important sector of collagen I [32]. The three parameters are the important indicators in evaluating bone loss [32].…”

Section: T-es Reduced Bone Resorption-related Parameters In Serum And...mentioning

confidence: 99%

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Hu,

Wan,

Zhu

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

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Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives

Han,

Kim,

Pack

2024

Marine Drugs

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Aging is closely linked to various health challenges, including cardiovascular disease, metabolic disorders, and neurodegenerative conditions. This study emphasizes the critical role of bioactive compounds derived from marine sources, such as antioxidants, omega-3 fatty acids, vitamins, minerals, and polysaccharides, in addressing oxidative stress, inflammation, and metabolic disorders closely related to aging. Incorporating these materials into functional foods not only provides essential nutrients but also delivers therapeutic effects, thereby promoting healthy aging and mitigating age-related diseases. The growth of the global anti-aging market, particularly in North America, Europe, and Asia, underscores the significance of this study. This review systematically analyzes the current research, identifying key bioactive compounds, their mechanisms of action, and their potential health benefits, thus highlighting the broad applicability of marine-derived bioactive compounds to enhancing healthy aging and improving the quality of life of aging populations.

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Osteogenic properties and anti-osteoporosis activity of calcium hydroxyapatite from Katsuwonus pelamis bone and its water-soluble forms

Cited by 2 publications

References 36 publications

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives

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