Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model

Abstract

In the rabbit pseudarthrosis model, gene expression data supported the hypothesis that successful pseudarthrosis repair is related to the induction of osteogenic and angiogenic cytokines by osteogenic protein-1.

The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review

“…Others are osteoporosis, minimal local bone graft, previous and long fusion 1 . Failures have been attributed to poor vascularity of a scarred fusion bed and persistence of systemic inhibitors, such as nicotine 11 . To Furlan et al 9 the population at risk for a spinal nonunion are patients with connective tissue disorders, individuals with a history of major diseases that could adversely affect bone healing, patients receiving medications that negatively affect bone healing, patients with a history of previous nonunion fusions, and/or patients with limited availability or poor quality of autogenous bone graft.…”

“…For the White et al 11 model it had up-regulation in the implantation of osteogenic protein-1 at the pseudarthrosis site. Gene expression data supported the hypothesis that the discrepancy in fusion success may be due to osteogenic protein-1's ability to up-regulate osteogenic and angiogenic cytokines required for fusion, and, thus, overcome nicotine's inhibition of local gene expression.…”