Osteoimmunity-regulating nanosilicate-reinforced hydrogels for enhancing osseointegration

Abstract

Following the introduction of osteo-immunomodulation as a new and important strategy to enhance material osseointegration, designing an appropriate immune response after biomaterial implantation has become a significant challenge for efficient...

Hybridized local and charge transfer dendrimers with near-unity exciton utilization for enabling high-efficiency solution-processed hyperfluorescent OLEDs

“…[10][11][12][13][14] Compared to the TTA process (62.5% in theory), the TADF mechanism is more popular in OLEDs because of its higher Z S value (100% in theory) and simpler molecular design rule. TADF emitters usually show a twisted molecular configuration with strong charge transfer (CT) excited state, which leads to spatial separation between the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO), 3,15,16 and then achieves the thermally activated upconversion process. Unfortunately, this strong CT state leads to a slow radiative rate and relatively long emission lifetime for TADF emitters, which easily induces triplet annihilation, leading to efficiency roll-off in the device.…”

“…The phenomenon demonstrates the existence of the excited CT state. To further understand the solvatochromic effect and the excited state property, a Lippert-Mataga solvatochromic model is constructed (Formulas [16][17][18][19]. According to the theoretical calculation at the B3LYP/def2-SVP level, the ground state dipole moment (m g ) of D-TTT-H and D-TTT-t Bu is estimated to be 0.38 and 0.35 D, respectively.…”

Nanoengineered Silica-Based Biomaterials for Regenerative Medicine

“…A high lease rate was observed in acidic environments (100% at pH 4, 65% at pH 5, and 1 pH 7) due to the pH-responsive transition of the gatekeepers from a closed to an state. This design holds promise for targeted delivery of anti-cancer drugs with acidic tumor microenvironment, potentially minimizing side effects on healthy tissu Expanding the potential of silica-based materials in bone repair, research explo novel nano-silicate-reinforced hydrogel (SMH) for combined bone repair and drug ery [119]. The SMH hydrogel incorporated bio-compatible polymer sodium alginate montmorillonite nanoparticles and harmine, an immunogen that promotes M2 m phage differentiation.…”

“…In vivo models further demons the effectiveness of SMH, showing an increase in M2 macrophages, reduced infla tion, and enhanced bone formation. These findings suggest that SMH holds promis Expanding the potential of silica-based materials in bone repair, research explored a novel nano-silicate-reinforced hydrogel (SMH) for combined bone repair and drug delivery [119]. The SMH hydrogel incorporated bio-compatible polymer sodium alginate with montmorillonite nanoparticles and harmine, an immunogen that promotes M2 macrophage differentiation.…”

“…Expanding the potential of silica-based materials in bone repair, research explored a novel nano-silicate-reinforced hydrogel (SMH) for combined bone repair and drug delivery [ 119 ]. The SMH hydrogel incorporated bio-compatible polymer sodium alginate with montmorillonite nanoparticles and harmine, an immunogen that promotes M2 macrophage differentiation.…”