Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis

Kähkönen, Tiina E.; Halleen, Jussi M.; Bernoulli, Jenni

doi:10.3390/cells10061529

Cited by 15 publications

(13 citation statements)

References 196 publications

(261 reference statements)

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“…It is not surprising, however, that bone-targeted therapies also display systemic immunological effects, regarding the interactions between immune and bone cells, which can partially cause eliminatory anti-tumor effects. Indeed, zoledronic acid and denosumab can modulate immune cells activity, such as γδ T cells, macrophages, and CD4 + Tregs, in many different types of cancer, including breast cancer, leading to an increase in T-cellmediated anti-tumor cytotoxic effects [135]. Moreover, the knowledge about how current treatments affect the immune landscape in bone metastatic microenvironment is scarcely known.…”

Section: Preclinical and Clinical Implicationsmentioning

confidence: 99%

Perspective Chapter: Breast-Tumor-Derived Bone Pre-Metastatic Disease – Interplay between Immune and Bone Cells within Bone Marrow Microenvironment

Monteiro¹,

Bonomo²

2023

Bone Tumours - A Comprehensive Review of Selected Topics

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The bone marrow is a dynamic organ where osteogenesis and bone remodeling take place side by side with hematopoiesis and the maintenance of immunological memory. It provides a unique microenvironment favoring the colonization and outgrowth of breast cancer cells. The outcome of breast-cancer-derived bone metastases depends on the formation of a pre-metastatic niche, which is initiated through “education” of non-tumoral cells present in the primary cancerous niche. Among other participants, immune cells and their secreted factors can boost the successful seeding of the distant disease. In this chapter, we discuss the reciprocal interplay between bone and T and B cells, particularly in pathological contexts. In the first part, we are exploring the knowledge brought by the osteoimmunology field, especially from the best studied disease in this area, rheumatoid arthritis. In the second part, we summarize the latest findings on underlying cellular and molecular mechanisms for breast-cancer-derived bone pre-metastatic niche formation. In addition, we explore the concept that breast-tumor-primed T and B cells function as messengers from the periphery to the bone marrow, alter bone turnover homeostasis in favor of osteoclasts, before tumor colonization, leading to a pre-metastatic niche formation to further the development of bone metastases.

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Section: Preclinical and Clinical Implicationsmentioning

confidence: 99%

Perspective Chapter: Breast-Tumor-Derived Bone Pre-Metastatic Disease – Interplay between Immune and Bone Cells within Bone Marrow Microenvironment

Monteiro¹,

Bonomo²

2023

Bone Tumours - A Comprehensive Review of Selected Topics

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“…This term defines all the direct and indirect relations between the immunity of bone tissues and its crosstalk with bone cancer development and metastasis formation. Notably, OIO includes all the specific therapeutic targets which can be adopted to contrast bone tumors and bone tissue metastatic expansion [14].…”

Section: Metastatic Expansion: New Mechanisms and Future Directionsmentioning

confidence: 99%

Cancer Immunology: From Molecular Mechanisms to Therapeutic Opportunities

Mattei

Alfaro

Keisari

2022

Cells

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“…Bone marrow represents a unique immune microenvironment containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells [ 280 ]. The diverse interplay between immune cells and the skeletal system has been extensively reviewed elsewhere [ 281 , 282 , 283 ]. Importantly, tumor cells can create an immunosuppressive bone metastatic microenvironment, which leads to low response rates to different cancer therapies [ 84 ].…”

Section: Diagnosis and Therapy Of Bone Metastasesmentioning

confidence: 99%

“…Furthermore, it is important to note that immunotherapies are associated with skeletal-related adverse effects such as compression of the spinal cord, or fractures and lesions caused by increased bone resorption [ 304 , 305 ]. Recently, the concept of osteoimmuno-oncology has been introduced, which takes into account the interactions between tumor, immune and bone cells in the bone microenvironment and may thus provide the basis for the development of more effective immunotherapies against bone metastasis in the future [ 281 ].…”

Section: Diagnosis and Therapy Of Bone Metastasesmentioning

confidence: 99%

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban

Fock

Aryee

et al. 2021

Cells

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Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, well-tolerated and more successful treatments for a significant improvement of patients’ quality of life and disease outcome. In this review, we provide comparative mechanistic insights into the bone metastatic process of various solid tumors, including pediatric cancers. We also highlight current and innovative approaches to biologically targeted therapy and immunotherapy. In particular, we discuss the role of the bone marrow microenvironment in the attraction, homing, dormancy and outgrowth of metastatic tumor cells and the ensuing therapeutic implications. Multiple signaling pathways have been described to contribute to metastatic spread to the bone of specific cancer entities, with most knowledge derived from the study of breast and prostate cancer. However, it is likely that similar mechanisms are involved in different types of cancer, including multiple myeloma, primary bone sarcomas and neuroblastoma. The metastatic rate-limiting interaction of tumor cells with the various cellular and noncellular components of the bone-marrow niche provides attractive therapeutic targets, which are already partially exploited by novel promising immunotherapies.

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Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis

Cited by 15 publications

References 196 publications

Perspective Chapter: Breast-Tumor-Derived Bone Pre-Metastatic Disease – Interplay between Immune and Bone Cells within Bone Marrow Microenvironment

Perspective Chapter: Breast-Tumor-Derived Bone Pre-Metastatic Disease – Interplay between Immune and Bone Cells within Bone Marrow Microenvironment

Cancer Immunology: From Molecular Mechanisms to Therapeutic Opportunities

Mechanisms, Diagnosis and Treatment of Bone Metastases

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