Osteoimmunology and osteonecrosis of the femoral head

Ma, Maoxiao; Tan, Zhen; Li, Wuyin; Zhang, Hong; Liu, Youwen; Chen, Yue

doi:10.1302/2046-3758.111.bjr-2021-0467.r1

Cited by 14 publications

(7 citation statements)

References 35 publications

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“…At this stage, the bone structure remains unchanged and may appear normal on X-ray and CT, whereas early bone marrow disturbances may be detected on MRI. [ 18 ] Subsequently, bone marrow mesenchymal stem cells proliferate and differentiate into osteoblasts, resulting in new homogeneous bone, and osteoclasts undergo bone resorption, indicating the beginning of the regenerative phase. During this phase, osteoclasts begin to crawl for replacement action, which may appear as a subchondral fracture on an X-ray.…”

Section: Discussionmentioning

confidence: 99%

X-ray, digital tomographic fusion, CT, and MRI in early ischemic necrosis of the femoral head

Ge,

Wang,

Zhang

2024

Medicine

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To investigate the imaging performance of radiography, digital tomographic fusion (DTS), computed tomography (CT), and magnetic resonance imaging (MRI) in the diagnosis of early avascular necrosis of the femoral head (ANFH). A total of 220 patients with ANFH who visited our hospital from January 2020 to January 2022 were included in the study. X-ray, DTS, CT, and MRI examinations of both hips were performed for all patients. The trabecular structure, bone density changes, femoral head morphology, and joint space changes were observed using the aforementioned imaging modalities. The staging was performed according to the Association Research Circulation Osseous (ARCO) criteria. The diagnostic detection rate of each imaging modality, and the sensitivity, specificity, positive predictive value, and negative predictive value of each examination for diagnosing early ANFH were calculated and compared. Patients were diagnosed with stage I (n = 65), stage II (n = 85), stage III (n = 32), and stage IV (n = 38) ANFH. For MRI, the detection rate (97.7%), sensitivity (94.7%), specificity (88.6%), positive predictive value (95.9%), and negative predictive value (92.5%), for diagnosing early ANFH, were significantly higher than those of other imaging methods (P < .05). MRI is the most accurate and sensitive imaging method for diagnosing early ANFH and has important clinical applications.

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Section: Discussionmentioning

confidence: 99%

X-ray, digital tomographic fusion, CT, and MRI in early ischemic necrosis of the femoral head

Ge,

Wang,

Zhang

2024

Medicine

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“…In addition, we found that ONFH immune infiltration was predominantly influenced by immune cells such as Gmma delta cell and Th2 cell under different m6A modifications. T cells, being a key component of cell mediated acquired immunity, are closely associated with the development of ONFH [42]. Th2 cells, direct the immune response through producing signature cytokines to control pathogens and regulate other immune cells [43].…”

Section: Discussionmentioning

confidence: 99%

m6A methylation modification and immune infiltration analysis in osteonecrosis of the femoral head

Fang,

Peng,

Lin

et al. 2024

J Orthop Surg Res

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Osteonecrosis of the femoral head (ONFH) is a elaborate hip disease characterized by collapse of femoral head and osteoarthritis. RNA N6-methyladenosine (m6A) plays a crucial role in a lot of biological processes within eukaryotic cells. However, the role of m6A in the regulation of ONFH remains unclear. In this study, we identified the m6A regulators in ONFH and performed subtype classification. We identified 7 significantly differentially expressed m6A regulators through the analysis of differences between ONFH and normal samples in the Gene Expression Omnibus (GEO) database. A random forest algorithm was employed to monitor these regulators to assess the risk of developing ONFH. We constructed a nomogram based on these 7 regulators. The decision curve analysis suggested that patients can benefit from the nomogram model. We classified the ONFH samples into two m6A models according to these 7 regulators through consensus clustering algorithm. After that, we evaluated those two m6A patterns using principal component analysis. We assessed the scores of those two m6A patterns and their relationship with immune infiltration. We observed a higher m6A score of type A than that of type B. Finally, we performed a cross-validation of crucial m6A regulatory factors in ONFH using external datasets and femoral head bone samples. In conclusion, we believed that the m6A pattern could provide a novel diagnostic strategy and offer new insights for molecularly targeted therapy of ONFH.

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“…There is increasing evidence that inflammatory osteoimmunology is critical to the development of osteonecrosis [49]. Cytokines that regulate inflammatory responses contribute to the onset and progression of osteonecrosis [17,50,51].…”

Section: Discussionmentioning

confidence: 99%

Medication-Related Osteonecrosis of the Jaw: A Systematic Review and a Bioinformatic Analysis

Laputková,

Talian,

Schwartzová

2023

IJMS

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The objective was to evaluate the current evidence regarding the etiology of medication-related osteonecrosis of the jaw (MRONJ). This study systematically reviewed the literature by searching PubMed, Web of Science, and ProQuest databases for genes, proteins, and microRNAs associated with MRONJ from the earliest records through April 2023. Conference abstracts, letters, review articles, non-human studies, and non-English publications were excluded. Twelve studies meeting the inclusion criteria involving exposure of human oral mucosa, blood, serum, saliva, or adjacent bone or periodontium to anti-resorptive or anti-angiogenic agents were analyzed. The Cochrane Collaboration risk assessment tool was used to assess the quality of the studies. A total of 824 differentially expressed genes/proteins (DEGs) and 22 microRNAs were extracted for further bioinformatic analysis using Cytoscape, STRING, BiNGO, cytoHubba, MCODE, and ReactomeFI software packages and web-based platforms: DIANA mirPath, OmicsNet, and miRNet tools. The analysis yielded an interactome consisting of 17 hub genes and hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-145, hsa-mir-186, hsa-mir-221, and hsa-mir-424. A dominance of cytokine pathways was observed in both the cluster of hub DEGs and the interactome of hub genes with dysregulated miRNAs. In conclusion, a panel of genes, miRNAs, and related pathways were found, which is a step toward understanding the complexity of the disease.

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Osteoimmunology and osteonecrosis of the femoral head

Cited by 14 publications

References 35 publications

X-ray, digital tomographic fusion, CT, and MRI in early ischemic necrosis of the femoral head

X-ray, digital tomographic fusion, CT, and MRI in early ischemic necrosis of the femoral head

m6A methylation modification and immune infiltration analysis in osteonecrosis of the femoral head

Medication-Related Osteonecrosis of the Jaw: A Systematic Review and a Bioinformatic Analysis

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