Osteolytic lesions in myelofibrosis

Abstract

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Osteolytic lesion in polycythemia vera: First report and review of literature

“…In all 16 cases investigations revealed progressive disease (i.e., worsening fibrosis, accelerated phase MPN or AML) along with the presence of osteolytic lesions; though diagnostic procedures were often delayed until further symptoms or cytopenias developed [6][7][8][9][10][11][12][13][14][15][16][18][19][20][21]. Chambers et al reported a patient with longstanding history of PV managed with hydroxyurea who presented to her local hospital after a fall and imaging revealed the presence of an osteolytic lesion [17].…”

“…In total, 16 case reports were found, highlighting that osteolytic lesion secondary to MPNs is rare (Table 1 ) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. All patients reported new or worsening bone pain as a presenting symptom.…”

“…Treatments provided for bone pain included palliative radiation [ 8 , 20 ], orthopedic surgery for pathological fracture [ 11 , 19 ], steroid therapy [ 6 , 16 ], JAK‐inhibitor [ 18 ], and chemotherapy [ 6 , 10 , 14 ]. In 14 cases, therapies only provided temporary symptomatic relief; and the osteolytic lesions either remained unchanged [ 6 , 7 , 8 , 9 , 10 , 11 , 13 , 15 , 16 , 17 , 19 , 21 ] or additional osteolytic lesions developed [ 20 ].…”

“…In very rare situations, patients with MPN can develop osteolytic lesions [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. We report the first case of an osteolytic lesion in a chronic‐phase PV patient, and review published case reports of MPN patients with osteolytic lesions to summarize the clinical characteristics and implications for patient care.…”

“…Patients with MPN can experience a constellation of debilitating symptoms that negatively impact their quality of life [2][3][4][5]. In prior surveys of patients with MPNs, bone pain was the fourth most common symptom reported by 44% of patients and rated as "very severe" in up to a third of MF patients [2][3][4][5].In very rare situations, patients with MPN can develop osteolytic lesions [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. We report the first case of an osteolytic lesion in a chronic-phase PV patient, and review published case reports of MPN patients with osteolytic lesions to summarize the clinical characteristics and implications for patient care.…”