Osteomalacia and sacroiliitis

Mahou, Soumaya El; Moineuse, Christine; Navaux, F; Cantagrel, Alain; Mazières, B; Laroche, Michel

doi:10.1016/s1297-319x(03)00054-x

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Elevated bone density at the lumbar spine, both with increased and decreased bone mass at the femoral neck, has been reported in patients with SSpA and hypophosphataemia due to renal phosphate wasting 21 22. However, underlying RTA, as a possible aetiology of hypophosphataemia, was not searched for in those patients.…”

Section: Discussionmentioning

confidence: 99%

Secondary distal renal tubular acidosis and sclerotic metabolic bone disease in seronegative spondyloarthropathy

et al. 2022

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Adults with distal renal tubular acidosis (dRTA) commonly present with hypokalaemia (with/without paralysis), nephrolithiasis/nephrocalcinosis and vague musculoskeletal symptoms. All adults with dRTA should be thoroughly evaluated for systemic diseases, certain medications and toxins. The leading cause of acquired or secondary dRTA in adults is primary Sjögren syndrome (SS); however, other collagen vascular diseases (CVDs) including seronegative spondyloarthropathy (SSpA) may at times give rise to secondary dRTA. Metabolic bone disease is often encountered in adults with dRTA, and the list includes osteomalacia and secondary osteoporosis; sclerotic metabolic bone disease is an extremely rare manifestation of dRTA. Coexistence of dRTA and sclerotic bone disease is seen in primary dRTA due to mutation in CA2 gene and acquired dRTA secondary to systemic fluorosis. Primary SS and SSpA, rarely if ever, may also lead to both secondary dRTA and osteosclerosis. Circulating autoantibodies against carbonic anhydrase II and possibly calcium sensing receptor may explain both these features in patients with CVD.

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Section: Discussionmentioning

confidence: 99%

Secondary distal renal tubular acidosis and sclerotic metabolic bone disease in seronegative spondyloarthropathy

et al. 2022

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“…Vitamin D deficiency manifests as rickets in children, while in adults osteomalacia is the prevailing manifestation. Osteomalacia is characterized by impaired mineralization of bone matrix [11]. The onset of osteomalacia is usually insidious.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency as a Cause of Flank Pain

Din¹,

Salem²,

Abdulazim³

et al. 2017

J Clin Exp Nephrol

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Introduction: Loin pain is a relatively common complaint seen in a variety of clinical settings. Many of these cases seek medical advice of urologists and nephrologists based on the impression that this pain originates from the urinary tract. In spite of the importance of diseases of the urinary tract as causes of loin pain, many of the patients presenting with this complaint are devoid of any urinary abnormalities.

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Osteomalacia mimicking spondyloarthropathy: a case report

2014

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Osteomalacia is a metabolic bone disorder characterized by impaired mineralization of bone matrix. Symptoms of osteomalacia can be confused with other conditions such as spondyloarthropathy, polymyalgia rheumatica, polymyositis, and fibromyalgia. In this case, we report a patient with axial osteomalacia who developed low back pain, morning stiffness, and "grade 3 sacroiliitis" in pelvis X-ray, leading to the misdiagnosis as seronegative spondyloarthropathy. Serum biochemical studies revealed low serum phosphorus, low 25-hydroxy vitamin D3, normal calcium, elevated parathyroid hormone, and alkaline phosphatase levels. Her symptoms were relieved with vitamin D and calcium therapy. The diagnosis of osteomalacia should be considered in case of sacroiliitis and spondylitis.

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Osteomalacia and sacroiliitis

Cited by 4 publications

References 3 publications

Secondary distal renal tubular acidosis and sclerotic metabolic bone disease in seronegative spondyloarthropathy

Secondary distal renal tubular acidosis and sclerotic metabolic bone disease in seronegative spondyloarthropathy

Vitamin D Deficiency as a Cause of Flank Pain

Osteomalacia mimicking spondyloarthropathy: a case report

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