Osteomalacia of Very-Low-Birth-Weight Infants

Roberts, William A.; Badger, Virginia M.

doi:10.1097/01241398-198409000-00013

Cited by 7 publications

(2 citation statements)

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“…The insufficient intake of vitamin D has been implicated as one of the factors in the development of bone disease [ 4 – 6 ]. Various elements contribute to this insufficient vitamin D intake such as skin pigmentation [ 7 ], which presumably interferes with ultraviolet ray transmission through epidermis, genetic factors [ 8 , 9 ], social customs such as avoidance of sun exposure, consumption of chapattis (flattened rounded wheat bread) that is high in phytates which bind calcium in the gut and interfere with calcium absorption [ 10 ], lack of sun exposure and malnutrition to name a few important contributing factors.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency—A Clinical Spectrum: Is There a Symptomatic Nonosteomalacic State?

Kanekar

Sharma

Joshi

2010

International Journal of Endocrinology

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Vitamin D deficiency is not uncommon even in the sunny land of India. Lack of sun exposure and inadequate oral intake are both responsible for vitamin D deficiency. This article provides a retrospective, examining the effects of Vitamin D deficiency in 71 patients. The study's inclusion criterion was low vitamin D level combined with musculoskeletal symptoms but without the presence of osteomalacia. All patients in this study were suspected to have vitamin D deficiency. The data were retrieved from the case-charts of patients seen between 1996 and 2001 at the rheumatology services of Hinduja Hospital, Mumbai, India. This study found no correlation between Vitamin D levels and symptoms, or between the severity of Vitamin D deficiency and the number of symptoms displayed. Subclinical vitamin D deficiency or preosteomalacic state was the term coined for individuals with vitamin D deficiency producing nonspecific musculoskeletal symptoms in the absence of clinical osteomalacia.

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Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency—A Clinical Spectrum: Is There a Symptomatic Nonosteomalacic State?

Kanekar

Sharma

Joshi

2010

International Journal of Endocrinology

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“…Disturbed bone mineralization and growth have been widely reported in infants born prematurely (1 -4). Clinical manifestations range from biochemical disturbances of mineral metabolism (5,6) to frank radiological changes of rickets (7)(8)(9)(10). It is widely accepted that the principal cause of bone disease in preterm infants is deficient bone mineral intake (1 I , 12).…”

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confidence: 99%

Early diet of preterm infants and bone mineralization at age five years

et al. 1996

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Bone disease with significantly reduced bone mineralization is common in preterm infants, and associated with later linear growth stunting at 18 months of age. Dietary insufficiency of calcium and phosphorus is thought to be the principal aetiological factor. We studied 54 children at mean age 5 years who were born preterm and had participated in a prospective multicentre study of effects of early diet on later growth and development. Diets compared were banked donor breast milk and preterm formula fed as a supplement to mother's own milk. Increasing human milk intake was strongly positively associated with later bone mineral content. Children fed predominantly human milk had greater bone mineral content than children of similar size born at term. These data suggest that the early nutritional environment of the preterm infant could play an important role in determining later skeletal growth and mineralization.

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