Osteomalazie und Vitamin-D-Hypovitaminose

Rader, C. P.; Corsten, N.; Rolf, Olaf

doi:10.1007/s00132-015-3141-9

Cited by 18 publications

(15 citation statements)

References 9 publications

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“…Moreover, several studies have also shown a relationship between musculoskeletal pain (e.g., low-back pain) and serum vitamin D level [34][35][36][37][38][39]. Among these studies, a cross-sectional study performed in Norway, including 572 patients with musculoskeletal pain, headaches or fatigue, concluded that more than half of all those subjects suffering from pain (58%) showed vitamin D levels < 50 nmol/L [40].…”

Section: Vitamin Dmentioning

confidence: 99%

Evidence-Based Role of Nutrients and Antioxidants for Chronic Pain Management in Musculoskeletal Frailty and Sarcopenia in Aging

et al. 2020

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Musculoskeletal disorders in aging and pain are closely connected because of multiple mechanisms leading to loss of mobility and autonomy. Pain is predictive of diability and worsening frailty and the strength of this relationship increases with the severity of pain. This study presents a systematic review of randomized controlled trials, cross sectional studies, and observational studies based on treatment of pain in adults with musculoskeletal disorders using nutritional non-pharmacological (nutrients and antioxidants) interventions. The review found the efficiency of the following topics: (a) accession of the patient to a dietary counselling (e.g., daily recommended amount of protein—equivalent to at least of 1 g of protein per kilogram of body weight); (b) intake of glutamic acid-rich such as soy, egg, and cod and tryptophan-rich foods such as milk and peanuts—or taking quick-acting, free-form supplements; (c) supplementation of vitamin D and magnesium, if lacking; (d) weekly consumption of fish or supplements of omega-3 fatty acids; and (e) availability of botanicals, in particular curcumin and gingerol. These non-pharmacological interventions can help the pain therapist to create a personalized medicine (precision medicine), acting with the maximum efficacy and safety, and also reducing the dosage of analgesic drugs needed.

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Section: Vitamin Dmentioning

confidence: 99%

Evidence-Based Role of Nutrients and Antioxidants for Chronic Pain Management in Musculoskeletal Frailty and Sarcopenia in Aging

et al. 2020

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“…In 1997, the recommended daily allowance for vitamin D intake to prevent a deficiency was 5 μg (200 IU) from childhood onwards up to late adulthood (50 years of age), 10 μg (400 IU) for people aged 50–70 years, and 15 μg (600 IU) for those over 70 years of age [ 6 ]. In presence of an osteomalacia, the weekly intake recommended by current guidelines should be much higher (20,000 to 40,000 IU/week) [ 42 ]. The necessary daily doses of vitamin D to prevent falls have been reported to be between 700 and 1000 IU [ 43 ].…”

Section: Vitamin D—prevalence Of Deficiency and Insufficiencymentioning

confidence: 99%

“…Osteomalacia, another metabolic bone disease mainly caused by malfunction of the vitamin D or phosphate metabolism, leads to a reduced bone mineralization in adults [ 12 , 42 ]. Unlike rickets, osteomalacia is rare in children [ 8 ].…”

Section: Bone Healthmentioning

confidence: 99%

“…However, there is no specific blood parameter to prove the presence of osteomalacia. Hence, osteomalacia can be diagnosed on the basis of decreased serum calcium or phosphate levels and an elevated alkaline phosphatase [ 12 , 42 , 52 ]. On clinical examination, unspecific symptoms like musculoskeletal pain, usually located in the pelvis, the shoulders or the proximal part of the muscles, can be found.…”

Section: Bone Healthmentioning

confidence: 99%

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Crucial Role of Vitamin D in the Musculoskeletal System

et al. 2016

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Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ultraviolet rays from sunlight when the skin is exposed to initiate vitamin D synthesis. However, since vitamin D is biologically inert when obtained from sun exposure or diet, it must first be activated in human beings before functioning. The kidney and the liver play here a crucial role by hydroxylation of vitamin D to 25-hydroxyvitamin D in the liver and to 1,25-dihydroxyvitamin D in the kidney. In the past decades, it has been proven that vitamin D deficiency is involved in many diseases. Due to vitamin D’s central role in the musculoskeletal system and consequently the strong negative impact on bone health in cases of vitamin D deficiency, our aim was to underline its importance in bone physiology by summarizing recent findings on the correlation of vitamin D status and rickets, osteomalacia, osteopenia, primary and secondary osteoporosis as well as sarcopenia and musculoskeletal pain. While these diseases all positively correlate with a vitamin D deficiency, there is a great controversy regarding the appropriate vitamin D supplementation as both positive and negative effects on bone mineral density, musculoskeletal pain and incidence of falls are reported.

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“…Although all other biochemical indices, except vitamin D, were within normal range, osteomalacia in the hip area must be assumed in the clinical scenario of insufficient bilateral femur neck fracture. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Atraumatic Bilateral Fracture of the Femoral Neck in Young Male Patient with Suspected Osteomalacia

Yoon

Kwon

2017

J Bone Metab

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In this report, we describe the case of a healthy 37-year-old male patient without a history of disease, who developed atraumatic bilateral fracture of the femoral neck. Radiological and blood investigations revealed osteopenia and severe vitamin D deficiency (7.42 ng/mL), respectively, but patient had no apparent risk factors for insufficiency fracture. Bilateral osteosynthesis was obtained using cannulated screws and laboratory findings improved after vitamin D supplementation. This case highlights the effect of vitamin D deficiency on demineralization in a young male patient.

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Osteomalazie und Vitamin-D-Hypovitaminose

Cited by 18 publications

References 9 publications

Evidence-Based Role of Nutrients and Antioxidants for Chronic Pain Management in Musculoskeletal Frailty and Sarcopenia in Aging

Evidence-Based Role of Nutrients and Antioxidants for Chronic Pain Management in Musculoskeletal Frailty and Sarcopenia in Aging

Crucial Role of Vitamin D in the Musculoskeletal System

Atraumatic Bilateral Fracture of the Femoral Neck in Young Male Patient with Suspected Osteomalacia

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