Osteomielite crônica multifocal recorrente da mandíbula: relato de três casos

Paim, Luciana B.; Liphaus, Bernadete L.; Rocha, André Caroli; Castellanos, Aura Ligia Z.; Silva, Clóvis A.

doi:10.1590/s0021-75572003000500016

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…CNO is a rare inflammatory bone disease with intermittent course [8], characterized by recurring multifocal bone lesions [9]. The literature describes a female 5:1 predominance [5].…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of CNO is made by process of elimination and is based on clinical, laboratorial, radiological, bacteriological and histological data [1]. Evidence of inflammatory activity is heightened during phases of disease activity, with normalization in periods of clinic remission [8]. Bone biopsy shows nonspecific inflammation, fibrotic or hyperostotic regeneration, and cultures are negative [10].…”

Section: Discussionmentioning

confidence: 99%

“…Bone biopsy shows nonspecific inflammation, fibrotic or hyperostotic regeneration, and cultures are negative [10]. The scintigraphy reveals increased uptake in the affected areas, and helps perform diagnosis, which is done by process of elimination [8]. There are descriptions of association with other inflammatory diseases, such as Crhon's disease, palmoplantar pustulosis, psoriasis, Sweet's syndrome, among others [9].…”

Section: Discussionmentioning

confidence: 99%

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Use of infliximab in patient with chronic non-bacterial osteomyelitis, case report

Longo

Tonial

Skare

2019

archmed

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Introduction: chronic non-bacterial osteomyelitis (CNO) is a non-infectious inflammatory of unknown etiology. Case description: ABA, female, 16 years old, was admitted with a pain in her left thigh. At the time, it was suspected to be caused by a tumor, and a bone scintigraphy was requested, which evidenced a focal area of increased uptake in the distal metadiaphyseal area of the left femur. A bone biopsy was performed, and its result was compatible with chronic osteomyelitis. The patient started taking pamidronate (withdrawn due to treatment failure) and methotrexate (subsequently suspended due to urticarial reaction). After some years of clinical stability, a new focal area of osteomyelitis appeared, in the distal right femur. The use of anti-TNF (infliximab) was chosen, resulting in an improvement of the algic state. Discussion: the diagnosis of CNO is made by process of elimination and is based on clinical, laboratorial, radiological, bacteriological and histological data. Non-hormonal anti-inflammatory and bisphosphonate drugs are recommended as initial therapy. Disease-modifying drugs, steroids and anti-TNFα have been used in severe and recurring cases. Conclusion: the authors present a CNO case with good response to anti-TNFα after treatment failure with bisphosphonates.

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“…CNO is a rare inflammatory bone disease with intermittent course [8], characterized by recurring multifocal bone lesions [9]. The literature describes a female 5:1 predominance [5].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Use of infliximab in patient with chronic non-bacterial osteomyelitis, case report

Longo

Tonial

Skare

2019

archmed

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“… 4 Patients usually present with insidious onset of heat, pain, and soft-tissue edema, restricted to one or more bones. 5 The lower limbs are the most affected, 5 with metaphyses or equivalent sites being the most common locations. 6…”

Section: Discussionmentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis: a case report

Oliveira

Costa

Cundari

et al. 2017

Revista Brasileira de Ortopedia (English Edition)

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Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic inflammatory disease that affects mainly children and young adults. The clinical signs and symptoms are nonspecific, hindering and delaying diagnosis. Radiological and histopathological tests are essential for its definition. A case of CRMO is reported, demonstrating the importance of clinical, laboratory, and radiological data for diagnosis.

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“…O tratamento é realizado com antiinflamatórios não hormonais, corticosteróides ou metotrexato. A oxigenação hiperbárica pode ser usada como terapêutica adjuvante nos casos refratários (9) , como foi utilizada em dois de nossos casos.…”

Section: Discussionunclassified