Osteomyelitis complicating three types of traumatic hand wound

Ja, Lewis; Dr, Miller; Sg, Davies

doi:10.12968/jowc.2004.13.7.26640

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Staphylococcus aureus strain for bacterial inoculation was used in almost all of them, because this is the most common pathogen in the setting of osteomyelitis [3, 39]. Furthermore, rats and rabbits were used in most studies because they are big enough to create stable long bone infections without giant efforts; while on the other hand they are small enough to be housed and handled easily [40–43].…”

Section: Discussionmentioning

confidence: 99%

Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis

et al. 2017

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BackgroundWhen bacteria colony persist within a biofilm, suitable drugs are not yet available for the eradication of biofilm-producing bacteria. The aim of this study is to study the effect of magnetic nano-particles-induced hyperthermia on destroying biofilm and promoting bactericidal effects of antibiotics in the treatment of osteomyelitis.MethodsSixty 12-weeks-old male Wistar rats were used. A metallic 18G needle was implanted into the bone marrow cavity of distal femur after the injection of Methicillin-sensitive Staphylococcus aureus (MSSA). All animals were divided into 5 different treatment modalities. The microbiological evaluation, scanning electron microscope examination, radiographic examination and then micro-CT evaluation of peri-implant bone resorption were analyzed.ResultsThe pathomorphological characteristics of biofilm formation were completed after 40-days induction of osteomyelitis. The inserted implants can be heated upto 75 °C by magnetic heating without any significant thermal damage on the surrounding tissue. We also demonstrated that systemic administration of vancomycin [VC (i.m.)] could not eradicate the bacteria; but, local administration of vancomycin into the femoral canal and the presence of magnetic nanoparticles hyperthermia did enhance the eradication of bacteria in a biofilm-based colony. In these two groups, the percent bone volume (BV/TV: %) was significantly higher than that of the positive control.ConclusionsFor the treatment of chronic osteomyelitis, we developed a new modality to improve antibiotic efficacy; the protection effect of biofilms on bacteria could be destroyed by magnetic nanoparticles-induced hyperthermia and therapeutic effect of systemic antibiotics could be enhanced.

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Section: Discussionmentioning

confidence: 99%

Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis

et al. 2017

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“…These bone infections require long‐term antibiotic treatment as well as surgical debridement to remove necrotic bone and the osseous sequestrum (Darley and MacGowan 2004). Staphylococcus aureus is the most common cause of bacterial osteomyelitis (Lewis et al. 2004).…”

Section: Introductionmentioning

confidence: 99%

“…These bone infections require long-term antibiotic treatment as well as surgical debridement to remove necrotic bone and the osseous sequestrum (Darley and MacGowan 2004). Staphylococcus aureus is the most common cause of bacterial osteomyeli-tis (Lewis et al 2004). Glycopeptides, the only class of antibiotics with reasonable efficacy against methicillinresistant Staphylococcus aureus (MRSA) strains, have been extensively used for the treatment of bone and joint infections (Hiramatsu et al 1997).…”

Section: Introductionmentioning

confidence: 99%

A new experimental model of acute osteomyelitis due to methicillin-resistant Staphylococcus aureus in rabbit

Gaudin

Valle

Hamel

et al. 2011

Letters in Applied Microbiology

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Aims: To assess the impact of antibiotic therapy on severe osseous infections, animal models of chronic bacterial infections have been developed; however, these models suffer from many experimental limitations. The aim of this work was to develop a new model system in which high levels of bacteria are obtained within femoral bone marrow and bone tissue, and such infections are maintained for at least 14 days. Methods and Results: Experimental osteomyelitis was induced in 25 New Zealand white rabbits. A 109 CFU ml−1 suspension of methicillin‐resistant Staphylococcus aureus was injected into the knee after bone trepanation. On day 3, surgical debridement was performed to mimic a surgical procedure. Animals were euthanized 1, 2, 3, 9 and 14 days post‐inoculation to determine the bacterial counts in marrow and bone, and to evaluate the stability of the infection. Inoculated lesions also were assessed for changes in histological parameters on days 3 and 7 post‐inoculation. At days 1, 2, 3, 9 and 14 post‐inoculation, we observed 6·50 ± 0·64, 7·30 ± 0·49, 7·82 ± 0·19, 8·00 ± 1·48 and 8·99 ± 0·20 log10 CFU g−1 in bone marrow and 8·40 ± 0·68, 7·65 ± 0·27, 7·58 ± 0·30, 8·88 ± 0·52 and 8·28 ± 0·39 log10 CFU g−1 in bone tissue, respectively. No statistical differences in bacterial count were found between bone marrow and bone tissue at any time point. Conclusion: This new model of acute osteomyelitis was validated by histological and microbiological changes in the absence of sclerosing agents, and these changes remained stable for 14 days. Significance and Impact of the Study: These results describe a new experimental model of acute osteomyelitis and demonstrate its usefulness in assessing the activity of antibacterial agents in vivo soon after bone infection.

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“…In the patient history, prolonged time intervals from trauma and from onset of visible inflammation to clinical presentation can indicate that the infection has expanded to bone (Figs. 3a,b) [37,39]. Clinical signs of exclusive finger osteomyelitis can be non-specific and include focal tenderness and functional impairment (Fig.…”

Section: Clinical Findingsmentioning

confidence: 99%

Bone and joint infections of the hand

Sendi

Kaempfen

Uçkay

et al. 2020

Clinical Microbiology and Infection

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Background: Little guidance is currently available for standardized diagnostic protocols and therapeutic recommendations for bone and joint infections (BJIs) of the hand. Objectives: To summarize the available data in the scientific English-language literature on the diagnosis and treatment of native BJIs of the hand. To illustrate these concepts from a narrative point of view in areas where there is lack of evidence. Sources: We performed a systematic PubMed and Internet search of studies that investigated hand BJIs in adult patients. Content: Few studies have systematically investigated and validated diagnostic concepts, classifications or surgical treatment protocols. Most concepts derive from traditional intra-institutional experience, expert opinions and extrapolations from infections in large joints and long bones. Similarly, there is no uniformly accepted infection definition of BJIs of the hand. The best-documented literature is available for microbiological findings and antibiotic treatment duration in uncomplicated native joint arthritis of the fingers. Retrospective studies and one prospective randomized trial suggest that post-surgical targeted antibiotic therapy of 2 weeks results in a microbiological cure rate of 88%. Implications: Studies on diagnostic workup and infection definition and classification are urgently needed to compare inter-institutional outcome results and generate guidelines for the best patient care. For uncomplicated pyogenic arthritis of native joints, current evidence suggests that a 2-week course of antibiotic therapy following surgery cures the infection.

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Osteomyelitis complicating three types of traumatic hand wound

Cited by 6 publications

References 9 publications

Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis

Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis

A new experimental model of acute osteomyelitis due to methicillin-resistant Staphylococcus aureus in rabbit

Bone and joint infections of the hand

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