Greene's Infectious Diseases of the Dog and Cat 2021
DOI: 10.1016/b978-0-323-50934-3.00121-x
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Osteomyelitis, Discospondylitis, and Infectious Arthritis

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“…As the condition progresses chronically, colonisation by microorganisms occurs and progresses to form a biofilm because of the lack of antimicrobial and inflammatory cell supply caused by ischaemia. This biofilm comprises bacterial clusters within an exopolysaccharide matrix, providing protection against antibodies, phagocytosis and antimicrobial drugs for the bacteria (Sykes & Kapatkin, 2021 ). Reactive hyperaemia, which coexists with ischaemia, leads to increased osteoclast activity, resulting in localised osteoporosis and ultimately, hypertrophy of the bone cortex (Lew & Waldvogel, 2004 ).…”
Section: Introductionmentioning
confidence: 99%
“…As the condition progresses chronically, colonisation by microorganisms occurs and progresses to form a biofilm because of the lack of antimicrobial and inflammatory cell supply caused by ischaemia. This biofilm comprises bacterial clusters within an exopolysaccharide matrix, providing protection against antibodies, phagocytosis and antimicrobial drugs for the bacteria (Sykes & Kapatkin, 2021 ). Reactive hyperaemia, which coexists with ischaemia, leads to increased osteoclast activity, resulting in localised osteoporosis and ultimately, hypertrophy of the bone cortex (Lew & Waldvogel, 2004 ).…”
Section: Introductionmentioning
confidence: 99%