Osteonecrosis of the Hip: A Primer

Lespasio, Michelle J; Sodhi, Nipun; Mont, Michael A.

doi:10.7812/tpp/18-100

Cited by 95 publications

(110 citation statements)

References 42 publications

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“…This may be attributed to the role of haemoglobinopathy in the occurrence of aseptic osteonecrosis of the femoral head, which was reported in 20 of the 49 participants. In aseptic osteonecrosis of the femoral head, bone cells or osteocytes are affected by a metabolic disorder and their nutrition modified by a simple local reduction in circulation below the threshold that ensures their survival (Lespasio et al 2019;Narayanan et al 2017). This local reduction in circulation is thought to result from ischemic thrombosis of the artery of the round ligament, the nourishing artery of the femoral head (Lespasio et al 2019;Narayanan et al 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Its aetiologies include congenital hip abnormalities, metabolic defects, infections and blood disorders such as sickle cell disease (Kpadonou et al 2011;Oniankitan et al 2009;Ouedraogo et al 2015). This hereditary disease is more frequent in sub-Saharan Africa, India, the Middle East and Brazil (Lespasio, Sodhi & Mont 2019). Sickle cell disease is responsible for aseptic osteonecrosis of the Background: In Africa, primary hip osteoarthritis seems to be less frequent than in Europe.…”

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confidence: 99%

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Disability and functioning in primary and secondary hip osteoarthritis in Benin

Assogba

Natta

Kpadonou

et al. 2020

African Journal of Disability

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Background In Africa, primary hip osteoarthritis seems to be less frequent than in Europe. Sickle cell disease is responsible for aseptic osteonecrosis of the femoral head associated with secondary hip osteoarthritis. Very little evidence is available on the influence of aetiology (primary and secondary) and radiographic status on pain and disability in a Beninese population with hip osteoarthritis. Objectives The aim of this study was to compare the impacts of aetiology and radiographic status on pain, disability and quality of life in a Beninese population with hip osteoarthritis. Method This was a descriptive cross-sectional study, including participants recruited in the Clinic of Physical Medicine and Rehabilitation at the National Teaching Hospital in Cotonou. Assessment was based on the International Classification of Functioning, Disability and Health model. The main outcomes were severity of osteoarthritis, pain, range of motion, muscle strength, gait speed and quality of life. Statistical comparisons between the aetiologies were performed using a t -test or rank sum test. One-way analysis of variance was used to test the effect of radiographic status. Results Forty-nine participants (26 women and 23 men; mean age [standard deviation] 40.5 [17.9] years) were recruited. According to the aetiology (59.2% and 40.8% of primary and secondary osteoarthritis, respectively), there were no significant differences for any of the outcomes. Grades I, II, III and IV osteoarthritis were observed in 22.4%, 14.3%, 26.5% and 36.7% of the participants, respectively. Participants with grade IV osteoarthritis were more affected than those with grades I, II and III based on the Kellgren and Lawrence classification. Conclusion Aetiology did not influence pain, gait speed or quality of life. Participants with grade IV osteoarthritis had more pain, were more limited in walking and had a more impaired quality of life.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Disability and functioning in primary and secondary hip osteoarthritis in Benin

Assogba

Natta

Kpadonou

et al. 2020

African Journal of Disability

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“…Osteonecrosis (ON) is a debilitating condition that commonly affects young and middle-aged adults [1]. The disease is characterized by bone cell death that can result in mechanical failure, ultimately necessitating joint replacement [1][2][3][4][5]. ON most frequently develops at the femoral head [4] and accounts for approximately 10% of the total hip arthroplasties performed in the USA annually [6].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis

et al. 2021

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Summary This study investigated risk factors for osteonecrosis involving multiple joints (MJON) among glucocorticoid-treated patients. The best predictor of MJON was cumulative oral glucocorticoid dose. Risk of MJON was 12-fold higher in patients who had a second risk factor for osteonecrosis. Further research is needed into strategies for prevention of MJON. Introduction Osteonecrosis (ON) is a debilitating musculoskeletal condition in which bone cell death can lead to mechanical failure. When multiple joints are affected, pain and disability are compounded. Glucocorticoid treatment is one of the most common predisposing factors for ON. This study investigated risk factors for ON involving multiple joints (MJON) among glucocorticoid-treated patients. Methods Fifty-five adults with glucocorticoid-induced ON were prospectively enrolled. MJON was defined as ON in ≥ three joints. Route, dose, duration, and timing of glucocorticoid treatment were assessed. Results Mean age of enrolled subjects was 44 years, 58% were women. Half had underlying conditions associated with increased ON risk: systemic lupus erythematosus (29%), acute lymphoblastic leukemia (11%), HIV (9%), and alcohol use (4%). Mean daily oral dose of glucocorticoids was 29 mg. Average cumulative oral dose was 30 g over 5 years. The best predictor of MJON was cumulative oral glucocorticoid dose. For each increase of 1,000 mg, risk of MJON increased by 3.2% (95% CI 1.03, 1.67). Glucocorticoid exposure in the first 6 months of therapy, peak dose (oral or IV), and mean daily dose did not independently increase risk of MJON. The risk of MJON was 12-fold in patients who had a second risk factor (95% CI 3.2, 44.4). Conclusions Among patients with glucocorticoid-induced ON, cumulative oral dose was the best predictor of multi-joint disease; initial doses of IV and oral glucocorticoids did not independently increase risk. Further research is needed to better define optimal strategies for prevention and treatment of MJON.

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“…Severe cases can lead to the destruction of subchondral bone or the collapse of an entire joint. 1 The most common sites for AVN to occur are the femoral head (FH), knee, talus, and humeral head. The hip is the most common location overall.…”

Section: Introductionmentioning

confidence: 99%

Relationship of Alcohol and Tobacco With Avn of Femoral Head in Adult Indian Population

Suman

Sharma

Acharya

et al. 2021

ijmsdr

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Background: Avascular necrosis (AVN) or osteonecrosis is the death of bone tissues due to decreased blood flow of femoral head, it is a major orthopaedic disease with many risk factors including the chronic alcohol and tobacco consumption. Aims and objectives: To study the relationship of alcohol and tobacco with AVN of femoral head in adult population. Materials and Methods: This study included 72 patients of AVN of femoral head (ONFH) who attending our hospital between Sept 2018 to Sept 2020. History of alcoholism and tobacco consumption, detailed information of the amount and duration of smoking and alcohol intake was recorded. Results: Majority of the AVN patients were working age groups males (72%) and 28% were females. Out of 72 patient 55% had history of alcohol consumption and 60% were smokers which indicates a positive correlation of cellular toxicity with AVN of femoral head. Conclusion: Present study conclude that the alcohol ingestion and tobacco smoking are the major cause of cellular toxicity and AVN of femoral heads. Keywords: alcohol drinking, femur head necrosis, smoking

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Osteonecrosis of the Hip: A Primer

Cited by 95 publications

References 42 publications

Disability and functioning in primary and secondary hip osteoarthritis in Benin

Disability and functioning in primary and secondary hip osteoarthritis in Benin

Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis

Relationship of Alcohol and Tobacco With Avn of Femoral Head in Adult Indian Population

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