Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center

Nicolatou‐Galitis, Ourania; Papadopoulou, Erofili; Sarri, Triantafyllia; Boziari, Polyxeni; Karayianni, Aikaterini; Kyrtsonis, Marie‐Christine; Repousis, Panagiotis; Barbounis, V.; Migliorati, Cesar A.

doi:10.1016/j.tripleo.2011.02.037

Cited by 73 publications

(50 citation statements)

References 33 publications

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“…One limitation of our research was the non-controlled study design which may have led to an overestimation of BRONJ in non cancer-patients. There are very few RCTs dealing with this issue [1,8,18,19,28,39,51].…”

Section: Discussionmentioning

confidence: 99%

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

Fede

Fusco

Matranga

et al. 2013

European Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

Fede

Fusco

Matranga

et al. 2013

European Journal of Internal Medicine

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“…the american association of oral and Maxillofacial surgeons suggested a staging system based on four stages of BRonJ (31,34,42). -stage zero is represented by the non-exposed variant, where other symptoms and signs as pain, sinus tracts or radiologic markers are present (14).…”

Section: Pathogenesis and Clinical Presentationmentioning

confidence: 99%

Bisphosphonate-Related Osteonecrosis of the Jaws. A Severe Side Effect of Bisphosphonate Therapy

Janovska

2012

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Bisphosphonates (BP) are potent inhibitors of bone resorption used mainly in the treatment of metastatic bone disease and osteoporosis. By inhibiting bone resorption, they prevent complications as pathological fracture, pain, tumor-induced hypercalcemia. Even though patient's benefit of BP therapy is huge, various side effects may develop. Bisphosphonate-related osteonecrosis of the jaws (BRonJ) is among the most serious ones. oncologic patients receiving high doses of BP intravenously are at high risk of BRonJ development. BPs impair bone turnover leading to compromised bone healing which may result in the exposure of necrotic bone in the oral cavity frequently following tooth extraction or trauma of the oral mucosa. frank bone exposure may be complicated by secondary infection leading to osteomyelitis development with various symptoms and radiological findings. In the management of BRONJ, conservative therapy aiming to reduce the symptoms plays the main role. in patients with extensive bone involvement resective surgery may lead to complete recovery, provided that the procedure is correctly indicated. Since the treatment of BRONJ is difficult, prevention is the main goal. therefore in high risk patients dental preventive measures should be taken prior to bisphosphonate administration. this requires adequate communication between the prescribing physician, the patient and the dentist.

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“…Bununla birlikte, hiperbarik oksijen tedavisinin osteonekroz alanının tamamen yumuşak doku ile örtülmesinde tek başına etkisinin olmaması nedeniyle, ilave bir tedavi seçeneği olduğu da belirtilmektedir 83,84 . Diğer cerrahi olmayan tedavi seçenekleri ise; trombositçe zengin plazma 60,85,86 , düşük doz lazer 68 , 24,25,90,91 . Hastalığın evresine bakılmak-sızın, hareketli kemik sekestrları yumuşak doku iyileşmesinin sağlanabilmesi için mutlaka çıkartılma-lıdır.…”

Section: Tedavi̇unclassified

İlaçlara Bağli Çene Kemi̇ği̇ Osteonekrozu: Derleme

Duygu¹,

Cabbar²,

Yalçin³

et al. 2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center

Cited by 73 publications

References 33 publications

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

Bisphosphonate-Related Osteonecrosis of the Jaws. A Severe Side Effect of Bisphosphonate Therapy

İlaçlara Bağli Çene Kemi̇ği̇ Osteonekrozu: Derleme

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