Osteoneogenesis and Its Influencing Factors During Treatment With the Ilizarov Method

Fink, Bernd; Krieger, M; Strauß, J; C, Opheys; Menkhaus, S; Fischer, J; Rüther, W.

doi:10.1097/00003086-199602000-00036

Cited by 58 publications

(22 citation statements)

References 28 publications

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“…The same authors with collaborators published results on micromovement in 80 human tibial fractures which showed more rapid healing when the fracture was stimulated with axial compression/distraction of 1 mm at a frequency of 0.5 Hz during 20 minutes daily for 3 weeks at the maximum . This clinical observation was also reported in a paper from Fink et al (1996) where 58 callus distractions in humans were followed with focus on various parameters. In their study, young age of the patients and a high degree of loading were the most important factors to increase the callus formation.…”

Section: Weight Bearingsupporting

confidence: 70%

Reconstructive surgery of the human tibia by use of external ring fixator and the Ilizarov method

Kristiansen¹

2009

Acta Orthopaedica

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Section: Weight Bearingsupporting

confidence: 70%

Reconstructive surgery of the human tibia by use of external ring fixator and the Ilizarov method

Kristiansen¹

2009

Acta Orthopaedica

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“…Age and lengthening magnitude are known factors affecting the consolidation index [6,7]. Patients younger than 20 years and those between 20 and 29 years achieve healing considerably faster than older patients [7].…”

Section: Discussionmentioning

confidence: 99%

“…Insufficient bone regeneration and nonunion are known complications of limb lengthening techniques [6,7,22]. The biology of bone regeneration and healing and factors that affect its rate during limb lengthening using different forms of external fixators were studied extensively in animal models and clinical settings (Table 1) [1, 3, 6, 7, 9, 10, 16-18, 22, 24, 28, 30-32].…”

Section: Introductionmentioning

confidence: 99%

“…The biology of bone regeneration and healing and factors that affect its rate during limb lengthening using different forms of external fixators were studied extensively in animal models and clinical settings (Table 1) [1, 3, 6, 7, 9, 10, 16-18, 22, 24, 28, 30-32]. One of the most critical factors affecting bone regeneration is the distraction rate and rhythm [1,6,17,30]. Radiologic types of insufficient bone regeneration with limb lengthening using external fixators and treatment options have been described [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Insufficient Bone Regenerate after Intramedullary Femoral Lengthening: Risk Factors and Classification System

Kenawey

Krettek

Liodakis

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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“…Clinical experience with this technique has revealed an age-related decrease in the rate of bone formation [1, 8,15]. Specifically, patient age was the most important factor in determining new bone density in a recent clinical study [XI.…”

Section: Introductionmentioning

confidence: 99%

The effect of aging on distraction osteogenesis in the rat

Aronson

Gao

Shen

et al. 2001

Journal Orthopaedic Research

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The effect of age on bone formation in the limb lengthening model of distraction osteogenesis (DO) was investigated in two studies using Sprague-Dawley (SD) rats from two colonies at various ages (CAMM: 9 vs 24 months, Harlan: 4 vs 24 months). External fixators were placed on the right tibiae of 30 male SD rats (20 CAMM, 10 Harlan) and mid-diaphyseal osteotomies were performed. Distraction was performed at 0.2 mm bid for 20 days (CAMM) o r 14 days (Harlan). The experimental (DO) and control (contra-lateral) tibiae were removed for high-resolution radiography and decalcified histology. Videomicroscopy was used to quantitate radiodensity, histology (matrix type) and relative areas of cell proliferation. which was identified by proliferating cell nuclear antigen (PCNA) immunochemistry. Both studies demonstrated an age-related decrease in the percent mineralized bone (radiodensity) in the distraction gap (CAMM 9 vs 24 months: 68% vs 51%, P < 0.003; Harlan 4 vs 24 months: 95% vs 36%. P < 0.001) and no significant colony or distraction time-specific difference was seen between the two colonies of 24-month-old rats.Histology was performed on the Harlan rats. The DO gaps in the 24-month-old rats demonstrated less endosteal new bone compared to the 4-month-old rats ( P < 0.01), but equivalent periosteal new bone. Tn 4-month-old rats, PCNA-immunostained cells were organized along the primary matrix front (where the first deposition of osteoid occurs) extending across both periosteal and endosteal surfaces. In 24-month-old rats, PCNA + cells were organized in zones along the periosteal new bone fronts only and irregularly scattered throughout the endosteal gap within a fibrovascular non-ossifying matrix. These results indicate that 24-monthold rats have a relative deficit in endosteal bone formation which may not be related to cell proliferation but rather to cell organization. This model reflects the clinical situation where radiographic findings in older patients demonstrate significant delays in mineralization during DO. We believe this model of DO in aged rats presents unique in vivo opportunities to test hypotheses concerning (1) the effects of aging on bone repair, (2) the effects of pharmacological agents on bone repair in a geriatric setting. and (3) to study the mechanisms underlying DO.

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Osteoneogenesis and Its Influencing Factors During Treatment With the Ilizarov Method

Cited by 58 publications

References 28 publications

Reconstructive surgery of the human tibia by use of external ring fixator and the Ilizarov method

Reconstructive surgery of the human tibia by use of external ring fixator and the Ilizarov method

Insufficient Bone Regenerate after Intramedullary Femoral Lengthening: Risk Factors and Classification System

The effect of aging on distraction osteogenesis in the rat

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