Introduction. According to Russian and foreign studies, the frequency of clinical manifestations that are character for post-COVID syndrome continues to grow in people who have undergone a new coronavirus infection. In this regard, an urgent task is to increase the volume of available treatment methods, including non-drug ones, and their reasonable inclusion in medical rehabilitation.The aim of the study was to assess the osteopathic status and complaints in people who had a new coronavirus infection 3-6 months after the disease and their changes after osteopathic correction.Materials and methods. In the period from May 2020 to September 2021, a prospective study was carried out at the bases of the medical part of the rotational camp of the Yamal-Nenets Autonomous Okrug and ANO «Tyumen Institute of Manual Medicine», Clinic of Family Osteopathy of Doctor Aptekar′. The work is based on the results of osteopathic correction of 218 patients aged 27–54 years (average age — 42,3±3,2 years) who had a new coronavirus infection 3–6 months before the start of the study and who have clinical symptoms that are character for post-COVID syndrome. All patients underwent an assessment of osteopathic status, and there was an analysis of medical records.Results. During the process of osteopathic diagnosis in the examined group, prior to treatment, there were revealed dominant somatic dysfunctions of the regions of the head, thoracic and lumbar. The following most significant local disorders were diagnosed in regional somatic dysfunctions: compression of sphenobasilar synchondrosis (29,8 %), somatic dysfunction of the dura mater of the Brain sag type (25,2 %), somatic dysfunctions of the abdominal (6,9 %) and pelvic (6 %) diaphragms, sigmoid colon (6,9 %) and pericardial ligaments (15,1 %). At the same time, patients had complaints indicating a violation of cognitive functions, disorders of the nervous, cardiovascular, respiratory systems and the musculoskeletal system. After the completion of osteopathic correction, the detection frequency of the above dysfunctions decreased statistically significantly (p≤0.05), and there was obtained a statistically significant (p≤0,05) positive dynamics in complaints. Positive dynamics persisted 3 months after the completion of the osteopathic correction course.Conclusion. This study made it possible to establish that in people who had a new coronavirus infection, in the period 3–6 months after the disease, the compression of sphenobasilar synchondrosis, somatic dysfunction of the dura mater (according to the Brain sag type), somatic dysfunction of the thoracic and pelvic diaphragms, sigmoid colon and pericardial ligaments were the most often detected. After the osteopathic correction, patients showed a statistically significant (p≤0,05) decrease of the detection frequency of these somatic dysfunctions, and a positive trend in complaints.