Osteopenia

Ghosh, Subrata

doi:10.1002/9780470753170.ch27

Cited by 1 publication

(2 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic inflammatory bowel disease (IBD) is associated with an increased risk of developing osteoporosis, characterized by reduced bone mineral density (BMD) and an increased propensity towards fractures 1–6 . The pathogenesis of reduced BMD in IBD is multifactorial and the mechanisms involved are incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of antitumour necrosis factor‐α therapy on bone turnover in patients with active Crohn's disease: a prospective study

Ryan

Rüssel

Schurgers

et al. 2004

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background and aims: Patients with Crohn's disease are at increased risk of osteoporosis. Disease activity and circulating proinflammatory cytokines are thought to play a role in this process. Infliximab, a chimaeric antitumour necrosis factor‐α antibody is effective in the treatment of Crohn's disease. The aim of this study was to investigate the impact of treatment with infliximab on bone turnover in Crohn's disease patients. Methods: This was a prospective trial. Twenty‐four patients with active Crohn's disease were treated with infliximab (5 mg/kg). Bone markers were assayed pre‐ and post‐treatment. Bone formation was measured using serum bone‐specific alkaline phosphatase and total osteocalcin and bone resorption using serum N‐telopeptide cross‐linked type 1 collagen. Results: Infliximab therapy caused a significant increase in both markers of bone formation in patients with active Crohn's disease. No significant change in the bone resorption marker serum N‐telopeptide cross‐linked type 1 was found. Conclusion: Infliximab therapy had a significant beneficial effect on bone metabolism in patients with active Crohn's disease. These findings further support the theory that active ongoing inflammation and high levels of circulating cytokines play a pivotal role in the pathogenesis of bone loss in patients with Crohn's disease.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of reduced BMD in IBD is multifactorial and the mechanisms involved are incompletely understood. Nevertheless, vitamins D and K deficiency play a role in some Crohn's disease (CD) patients, 7 as does chronic steroid use in both CD and ulcerative colitis (UC) 2, 8 …”

Section: Introductionmentioning

confidence: 99%