Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption

Abstract

following correction should be noted. In Fig. 1b, the designed sequence of amino acids S 36 contains a typographical error in that only 35 of its 36 monomers appear. The missing amino acid is of type R and should be located between amino acids E (sixth) and G (seventh). The correct sequence is:Although this typographical error does not change the results presented in the paper because they were obtained with the correct number and sequence of amino acids, it constitutes a nuisance for anybody interested in reproducing our results, and we apologize for the inconvenience. We want to thank Prof. H. S. Chan, of the University of Toronto, for calling our attention to this error.Cell Biology. In the article "Quantitative analysis of biological membrane lipids at the low picomole level by nanoelectrospray ionization tandem mass spectrometry" by B.

Thirteen single-nucleotide polymorphisms in the human osteopontin gene identified by sequencing of the entire gene in Japanese individuals

“…OPN knockout mice are resistant to ovariectomy-induced bone resorption compared with wildtype mice (Yoshitake et al 1999). In light of such recent progress in our understanding of the biological functions of OPN, the polymorphic sites characterized in the present study will serve as useful markers for examining the potential role of OPN proteins in bone metabolism and in the pathogenesis of osteoporosis in Japanese patients.…”

Osteopontin: Role in immune regulation and stress responses

“…Its expression is elevated in response to mechanical stress in bone and the vasculature Yoshitake et al, 1999;Denhardt and Noda, 1998). OPN levels are elevated in response to the oxidative stresses existing in tumors, after reperfusion injury, and in inflammatory diseases such as inflammatory bowel disease, chronic obstructive pulmonary disease, and Parkinson's disease (Maetzler et al, 2007;Da Silva et al, 2006;Heguy et al, 2007).…”

“…OPN has been found to inhibit apoptosis in various situations Arafat et al, 2007;Hur et al, 2007). It has previously been reported that OPN is necessary for the HU-induced remodeling of bone Yoshitake et al, 1999).…”

L’ostéopontine, une molécule aux multiples facettes

“…Cela serait dû à un retard de résorption osseuse, malgré un nombre d'ostéoclastes élevé. Deux études ont mis en évidence les interactions entre les hormones et l'OPN dans l'os : les souris OPN -/-sont en effet résistantes à un modèle expérimental d'ostéoporose post-ménopausique (souris ovariectomisées) [44], et on note par ailleurs une inhibition de la résorption osseuse induite par la PTH (hormone parathyroïde), par inhibition de la prolifération des ostéoclastes [45]. De ce fait, l'ostéopontine est une cible thérapeutique potentielle pour traiter la déminéralisation, notamment celle survenant au cours de l'ostéoporose post-ménopausique.…”