Osteopontin Expression of Circulating T Cells and Plasma Osteopontin Levels are Increased in Relation to Severity of Heart Failure

Abstract

steopontin is an adhesion molecule that was first identified in bone tissue, 1 and it has been demonstrated that cardiomyocytes are an important source of osteopontin in left ventricular (LV) hypertrophy in both humans and rodents. 2 Interestingly, Singh et al showed that osteopontin is dramatically increased in the LV myocardium of a heart failure (HF) model in rats, after transition from LV hypertrophy to HF. 3 Furthermore, in a genetic animal model of dilated cardiomyopathy, 4 inflammatory cells express osteopontin, indicating a potential role for osteopontin during inflammatory processes in the heart. The plasma level of osteopontin was reported to be correlated with echocardiographic findings in the population of the Framingham Heart Study 5 and it has been reported that plasma osteopontin levels are elevated in patients with not only unstable angina but also acute myocardial infarction. 6,7 Plasma osteopontin levels change time-dependently and the changes are correlated with LV volume and function in patients with acute myocardial infarction. 7 Osteopontin has been reported to be released from the heart into the coronary circulation in proportion to LV systolic function and

Prognostic Significance of Plasma Osteopontin Levels in Patients Undergoing Percutaneous Coronary Intervention

“…26 OPN may play a role in plaque instability, and high plasma levels of OPN may reflect plaque instability or may be involved in plaque destabilization. Although plasma OPN levels are reportedly high in patients with heart failure, 27 none of the present patients had heart failure. In our study, high plasma levels of OPN were found to be related to further cardiovascular events in patients undergoing PCI, which is consistent with the results of a recent study by Minoretti et al 28 who investigated plasma OPN levels in patients with stable CAD and reported that OPN levels are independent predictors for adverse cardiovascular events.…”

Plasma osteopontin concentrations in preeclampsia – is there an association with endothelial injury?

“…Coskun et al found higher OPN concentrations in patients with acute coronary syndrome compared to patients with stable angina (48). Soe-jima et al showed that OPN production in peripheral T cells is increased in relation to the severity of heart failure (49). OPN presumably plays an important role in the development of atherosclerosis (25,50), acting in two different ways.…”

Association of pre-operative interleukin-6 levels with Interagency Registry for Mechanically Assisted Circulatory Support profiles and intensive care unit stay in left ventricular assist device patients

“…6 Plasma levels of osteopontin (OPN), a phosphorylated acidic glycoprotein involved in extracellular matrix inflammatory modulation, were related to the severity of HF. 8 An experimental model showed OPN is abundantly produced by activated T cells and macrophages, and its levels are markedly increased in the failing LV myocardium, indicating a potential role of OPN in the inflammatory processes occurring in the heart of severely ill patients supported by MCS.…”