Osteopontin Gene Expression Determines Spontaneous Metastatic Performance of Orthotopic Human Breast Cancer Xenografts

Suzuki, Mika; Mose, Evangeline; Galloy, Christine; Tarin, David

doi:10.2353/ajpath.2007.070232

Cited by 31 publications

(26 citation statements)

References 42 publications

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“…These works mainly investigated in vitro the pathways implicated in such regulation. Other in vivo studies demonstrated the involvement of such regulatory mechanisms in mice [41,42] and in human established a correlation between the activation of such pathways and bad prognosis [43].…”

Section: Osteopontinmentioning

confidence: 98%

Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis

Chiodoni

Colombo

Sangaletti

2010

Cancer Metastasis Rev

203

177

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The family of matricellular proteins comprises molecules with disparate biology. The main characteristic of matricellular proteins is to be expressed during tissue renewal and repair in order to "normalize" the tissue. Tumors are wound that do not heal, and tumor growth and metastasis can be viewed as a consequence of aberrant homeostasis, during which matricellular proteins are often upregulated. In the tumor microenvironment, they can be produced by both tumor cells and surrounding stromal cells, such as fibroblasts and macrophages. In this context, matricellular proteins can exert several functions that actively contribute to tumor progression. They may (a) regulate cellular adhesion and migration and extracellular matrix deposition, (b) control tumor infiltration by macrophages or other leukocytes, (c) affect tumor angiogenesis, (d) regulate TGFbeta and other growth factor receptor signals, (e) directly stimulate integrin receptors to transduce pro-survival or pro-migratory signals, and (f) regulate the wnt/beta-catenin pathways. Most of these functions contribute to settle a chronic low inflammatory state, whose involvement in tissue transformation and tumor progression is now established.

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Section: Osteopontinmentioning

confidence: 98%

Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis

Chiodoni

Colombo

Sangaletti

2010

Cancer Metastasis Rev

203

177

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“…phenotype [107]. OPN is expressed in a wide range of human tissues, where it localises to the luminal epithelial surfaces and has a role in cell adhesion, cytokine/growth factor production and immune response [108][109][110].…”

Section: Breast Cancer Stem Cells and Metastasismentioning

confidence: 99%

Cancer stem cells in breast cancer and metastasis

Lawson

Blatch

Edkins

2009

Breast Cancer Res Treat

109

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The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess stem cell characteristics and has been proposed to account for the development of a variety of malignancies, including breast cancer. These cancer stem cells (CSC) possess characteristics of both stem cells and cancer cells, in that they have the properties of self-renewal, asymmetric cell division, resistance to apoptosis, independent growth, tumourigenicity and metastatic potential. A CSC origin for breast cancer can neatly explain both the heterogeneity of breast cancers and the relapse of the tumours after treatment. However, many reports on CSC in the breast are contradictory. There is variation with respect to how breast cancer stem cells should be identified, their characteristics and a possible lack of correlation between clinical outcome and breast cancer stem cell status of a tumour. These combined factors have made breast cancer stem cells a highly contentious issue. In this review, we highlight the progress in the analysis of cancer stem cells, with an emphasis on breast cancer.

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“…8 is a secreted, integrin-binding phosphoprotein that has long been associated with cancer and other pathologies (1)(2)(3) and is an attractive candidate target for cancer therapy (4,5 ). Although many studies have suggested that OPN has potential clinical utility as a biomarker in multiple tumor types in both blood and tumor tissue, few studies have provided clinical outcome data on patients.…”

Section: Osteopontin (Opn)mentioning

confidence: 99%

New Dual Monoclonal ELISA for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple ELISAs

Anborgh¹,

Wilson²,

Tuck

et al. 2009

Clinical Chemistry

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BACKGROUND:A previously developed monoclonal/ polyclonal ELISA (Mono/Poly) to detect plasma concentrations of osteopontin (OPN) was shown to provide prognostic information in breast, prostate, and other cancers. Here we describe the clinical validation of a new dual monoclonal (Dual Mono) assay. We compared both assays with 4 assays that recognize defined regions of OPN protein (dual polyclonal systems 5-1, 4-1, 4-3 and polyclonal-monoclonal system 1-3).

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Osteopontin Gene Expression Determines Spontaneous Metastatic Performance of Orthotopic Human Breast Cancer Xenografts

Cited by 31 publications

References 42 publications

Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis

Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis

Cancer stem cells in breast cancer and metastasis

New Dual Monoclonal ELISA for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple ELISAs

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