Osteopontin is a novel prognostic biomarker in early-stage non-small cell lung cancer after surgical resection

Yan, Ci; Lv, Mengguo; Li, Hui; Song, Xinmiao; Fan, Yan; Cao, Shui; Ren, Xiubao

doi:10.1007/s00432-014-1902-1

Cited by 17 publications

(21 citation statements)

References 23 publications

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“…Our results suggest that lung neoplasm patients have higher OPN serum levels, demonstrating that OPN serum levels may be important in the development of lung neoplasm. Previous findings have shown that there was a significant reverse correlation between OPN and overall and disease-free survival ( 20 ). Generally, OPN, an integrin-binding protein, is involved in numerous signaling pathways, such as cancer cell growth, adhesion, apoptosis, metastasis, proliferation, migration, invasion, and angiogenesis ( 7 , 35 , 36 ).…”

Section: Discussionmentioning

confidence: 85%

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Correlation between lung neoplasm and serum level of osteopontin: A meta-analysis

Wang

et al. 2016

Biomedical Reports

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The aim of this meta-analysis was to evaluate the clinical significance of serum osteopontin (OPN) levels in lung neoplasm in patients to establish a novel diagnostic score model. Articles were identified by searching the PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure, and Wang Fang databases. Studies identified were pooled, and the standardized mean difference (SMD) and its corresponding 95% confidence interval (CI) were calculated. Subgroup analyses and publication bias detection were also conducted. Version 12.0 STATA software was used for statistical analysis. A final analysis of 1,327 subjects together (740 patients with lung neoplasms and 587 controls) was performed from 10 clinical case-control studies. The meta-analysis results showed a positive association between serum OPN levels and lung neoplasm (SMD=5.59, 95% CI: 1.85–3.32, P<0.001). The subgroup analysis by ethnicity detected that high levels of serum OPN may be the main risk factor for lung neoplasms in Asians (SMD=1.76, 95% CI: 1.24–2.29, P<0.001), but not in Caucasians (P=0.072). In conclusion, the present meta-analysis indicated that serum OPN levels were generally elevated in lung neoplasm patients, and thus, serum levels of OPN may be useful in diagnosing lung neoplasm in certain population groups.

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Section: Discussionmentioning

confidence: 85%

“…Therefore, OPN may be considered a new diagnostic marker for predicting, detecting, and evaluating lung neoplasm. Additionally, OPN is a promising biomarker for lung neoplasm prediction, diagnosis, prognosis and even metastasis ( 5 , 20 , 21 ). However, other studies have presented inconsistent results ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between lung neoplasm and serum level of osteopontin: A meta-analysis

Wang

et al. 2016

Biomedical Reports

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“…Three studies reported data on OPN expression and tumor TNM stage in NSCLC. 17 , 24 , 25 High OPN expression seemed to be associated with high tumor stage (III and IV) in two studies and low tumor stage in one study. Combined data from all the three studies showed a trend for a correlation between high OPN expression and high tumor TNM stage (III and IV) (OR =2.57, 95% CI 1.61–4.11, P <0.001) ( Figure 4 ) without any heterogeneity ( I 2 =0%, P =0.417).…”

Section: Resultsmentioning

confidence: 93%

“…Finally, a total of 13 studies 7 , 10 , 12 , 13 , 17 – 25 with 1,630 patients were included in our meta-analysis ( Figure 1 ). Four studies were performed in People’s Republic of China, 17 , 20 , 22 , 25 two in Japan, 12 , 13 two in America, 10 , 21 one in Norway, 19 one in England, 18 one in Italy, 7 one in Germany, 24 and one in Korea. 23 The sample size of each study varied from 25 to 244.…”

Section: Resultsmentioning

confidence: 99%

The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts

Wáng

Yang

Liu

et al. 2015

OTT

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In the last decade, osteopontin (OPN) was identified as one of the important proteins that promote the metastasis of tumor. However, the association between OPN overexpression and clinical outcome of non-small-cell lung cancer (NSCLC) was unclear. The purpose of this study is to investigate the role of OPN in NSCLC patients. A total of 13 studies are included to explore the relationship between the OPN elevation and the overall survival (OS) and disease-free survival (DFS) in NSCLC patients. We searched for related articles in PubMed, Web of Science, Google Scholar, and Cochrane Library databases, which were published before January 31, 2015. Hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) in the high OPN expression group compared with the low OPN expression group were calculated and analyzed. Primary results were summarized by using a fixed-effects model or a random-effects model. The stratified analyses in subgroups were also performed. Thirteen cohort studies, which involved 1,630 patients, were included. Subgroup analyses were performed by area and test method of OPN. We found that OPN was significantly associated with poor OS (HR =2.20, 95% CI 1.71–2.83, P<0.001) and DFS (HR =2.11, 95% CI 1.62–2.74, P<0.001) in NSCLC patients. OPN overexpression tended to be associated with the presence of advanced tumor TNM stage (III and IV) (OR =2.57, 95% CI 1.61–4.11, P<0.001). The Egger’s test suggested that there was no publication bias in OS studies (P=0.062) and DFS studies (P=0.740). These data indicate that OPN seems to have a significant predictive potential in estimating survival in NSCLC.

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“…[ 6 ] One new area of research in early-stage NSCLC is identifying molecular markers tumor node metastasis (TNM) staging to completely evaluate the prognosis of NSCLC patients and to define novel strategies. [ 7 ] Numerous novel prognostic factors, such as osteopontin (OPN) and matrix metalloproteinase-7 (MMP-7), have been identified in NSCLC patients that may provide potential therapeutic targets for NSCLC, which are certainly warranted. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Roles of osteopontin and matrix metalloproteinase-7 in occurrence, progression, and prognosis of nonsmall cell lung cancer

Sun

et al. 2015

J Res Med Sci

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Background:This study detected osteopontin (OPN) and matrix metalloproteinase-7 (MMP-7) expressions to explore the roles of OPN and MMP-7 in the occurrence, progression, and prognosis of nonsmall cell lung cancer (NSCLC).Materials and Methods:A retrospective study was conducted on NSCLC tissues (n = 152; case group) and adjacent nonneoplastic lung parenchyma (adjacent to tumor >5 cm; n = 152; control group) collected from 152 NSCLC patients. The protein expressions of OPN and MMP-7 were detected by immunohistochemistry. OPN and MMP-7 messenger RNA (mRNA) expressions were detected by reverse transcription polymerase chain reaction (RT-PCR).Results:The protein and mRNA expressions of OPN and MMP-7 in NSCLC tissues were evidently higher than those in adjacent nonneoplastic lung parenchyma (all P < 0.05). OPN protein and mRNA expression were associated with the degree of differentiation, tumor node metastasis (TNM) staging, and lymph node metastasis in NSCLC (all P < 0.05). MMP-7 protein expression was associated with TNM staging and lymph node metastasis (both P < 0.05) while MMP-7 mRNA expression was associated with the degree of differentiation, TNM staging, and lymph node metastasis (all P < 0.05). A significantly positive relativity was revealed between OPN expression and MMP-7 expression (protein: r = 0.789, P < 0.001; mRNA: r = 0.377, P < 0.001). Lymph node metastasis, TNM staging, OPN, and MMP-7 protein expressions were independent risk factors for the prognosis of NSCLC (all P < 0.05).Conclusion:High MMP-7 and OPN protein expressions are closely related to the occurrence, progression, and prognosis of NSCLC, and can be served as unfavorable prognostic factors for NSCLC.

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Osteopontin is a novel prognostic biomarker in early-stage non-small cell lung cancer after surgical resection

Abstract: These results suggest that OPN is commonly expressed in NSCLC and may guide the evaluation of prognosis with NSCLC, especially for early-stage patients.

Cited by 17 publications

References 23 publications

Correlation between lung neoplasm and serum level of osteopontin: A meta-analysis

Correlation between lung neoplasm and serum level of osteopontin: A meta-analysis

The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts

Roles of osteopontin and matrix metalloproteinase-7 in occurrence, progression, and prognosis of nonsmall cell lung cancer

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