Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam

Maeno, Yoshimasa; Nakazawa, Shozo; Dao, Le Duc; Tuấn, Nguyễn Văn; Giang, Nguyen Duc; Hanh, Truong Van; Taniguchi, Koki

doi:10.1016/j.actatropica.2006.05.001

Cited by 13 publications

(8 citation statements)

References 25 publications

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“…While TNF-α blockers are very effective agents, reactivation of infectious foci such as tuberculosis and fungal infection causes serious problems in clinics [20][21][22]. OPN is also known as a protective mediator for various infections [4,[23][24][25][26]. OPN-deficient mice were susceptible to various infectious agents including tuberculosis [24,27,28].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody

Yamamoto

Nakashima

Torikai

et al. 2007

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody

Yamamoto

Nakashima

Torikai

et al. 2007

International Immunopharmacology

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“…In the last decade, numerous in vitro and in vivo studies have proposed OPN as an important player in Th1 responses [24]–[27], [45]. For example, OPN induces IL-12 release by murine peritoneal macrophages, whereas OPN prevents lipopolysaccharide induced production of the Th2 cytokine IL-10 [24].…”

Section: Discussionmentioning

confidence: 99%

Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

et al. 2010

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BackgroundMelioidosis, caused by infection with Burkholderia (B.) pseudomallei, is a severe illness that is endemic in Southeast Asia. Osteopontin (OPN) is a phosphorylated glycoprotein that is involved in several immune responses including induction of T-helper 1 cytokines and recruitment of inflammatory cells.Methodology and Principal FindingsOPN levels were determined in plasma from 33 melioidosis patients and 31 healthy controls, and in wild-type (WT) mice intranasally infected with B. pseudomallei. OPN function was studied in experimental murine melioidosis using WT and OPN knockout (KO) mice. Plasma OPN levels were elevated in patients with severe melioidosis, even more so in patients who went on to die. In patients who recovered plasma OPN concentrations had decreased after treatment. In experimental melioidosis in mice plasma and pulmonary OPN levels were also increased. Whereas WT and OPN KO mice were indistinguishable during the first 24 hours after infection, after 72 hours OPN KO mice demonstrated reduced bacterial numbers in their lungs, diminished pulmonary tissue injury, especially due to less necrosis, and decreased neutrophil infiltration. Moreover, OPN KO mice displayed a delayed mortality as compared to WT mice. OPN deficiency did not influence the induction of proinflammatory cytokines.ConclusionsThese data suggest that sustained production of OPN impairs host defense during established septic melioidosis.

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“…38,39 The messenger RNA (mRNA) level of OPN was associated with T helper 1 cells-mediated immune responses. 40 Therefore, if severe presentation is caused by the lack of OPN-related immune responses, serum OPN should be low. Otherwise, higher OPN levels might be related to the augmented immune/ inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Severity Predictors in Eschar-Positive Scrub Typhus and Role of Serum Osteopontin

Park

Lee²,

Lee³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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We prospectively evaluated severity predictors in terms of host, microorganism, and treatment factors in 153 eschar-positive scrub typhus patients. Severity was assessed with the Acute Physiology and Chronic Health Evaluation (APACHE) II score (< 10 versus ≥ 10) and predefined criteria of severe complications. Genotypes of Orientia tsutsugamushi were determined. Independent risk factors for severity (APACHE II score ≥ 10) were old age, diabetes mellitus, serum osteopontin > 100 ng/mL, and a group of underlying diseases (congestive heart failure, cerebrovascular disease, chronic liver disease, bronchial asthma, and chronic obstructive lung diseases). Anemia (≤ 10 g/dL) and C-reactive protein > 10 mg/dL were indicators of current severity. Neither the delay in antibiotics administration nor strain types (Boryong, Taguchi, or Kanda/Kawasaki) contributed to the severity. The risk factors for severe complications were similar. Serum osteopontin > 100 ng/mL had a negative predictive value of 96% for severe complications. This marker can be used to rule out severe disease status.

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Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam

Cited by 13 publications

References 25 publications

Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody

Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody

Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

Severity Predictors in Eschar-Positive Scrub Typhus and Role of Serum Osteopontin

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