Osteopontin mediated eosinophils activation by group II innate lymphoid cells

Zeng, Qingxiang; Luo, Xiaodong; Zeng, Yinhui; Liu, Wenlong; Zhou, Lifeng

doi:10.1016/j.waojou.2022.100659

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…OPN plays an important role in innate immunity of allergic rhinitis (AR) by modulating group II innate lymphoid cells (ILC2s) and the interactions between ILC2s and eosinophils. In addition, OPN can promote ILC2 proliferation and upregulate the expression of GATA-binding protein 3 (GATA3), retinoid-related orphan receptor alpha (RORα), IL-5 and IL-13 [ 41 ].…”

Section: Regulatory Effects Of Opn On Immune Cellsmentioning

confidence: 99%

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Immunoregulatory Roles of Osteopontin in Diseases

Wang,

Niu

2024

Nutrients

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Osteopontin (OPN) is a multifunctional protein that plays a pivotal role in the immune system. It is involved in various biological processes, including cell adhesion, migration and survival. The study of the immunomodulatory effects of OPN is of paramount importance due to its potential therapeutic applications. A comprehensive understanding of how OPN regulates the immune response could pave the way for the development of novel treatments for a multitude of diseases, including autoimmune disorders, infectious diseases and cancer. Therefore, in the following paper, we provide a systematic overview of OPN and its immunoregulatory roles in various diseases, laying the foundation for the development of OPN-based therapies in the future.

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Section: Regulatory Effects Of Opn On Immune Cellsmentioning

confidence: 99%

“…Facilitate the maturation and differentiation of NK cells [39] ILC Enhance ILC2 proliferation and upregulate the expression of GATA3, RORα, IL-5 and IL-13 [41] T cell Modulate the generation of Th1, Th17 and CD8+ T cells [40,43]…”

Section: Nk Cellmentioning

confidence: 99%

Immunoregulatory Roles of Osteopontin in Diseases

Wang,

Niu

2024

Nutrients

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“…They mediate epithelial damage via preformed effector molecules’ release [ 29 ]. Several studies have shown a significant correlation between OPN protein level and the number and activity of eosinophils in the sputum of patients with eosinophilic asthma, suggesting the potential role of OPN in attracting eosinophils into asthmatic airways [ 29 , 30 , 31 ]. The main studies reporting the role of OPN in bronchial asthma are presented in Table 1 .…”

Section: The Role Of Opn In Bronchial Asthmamentioning

confidence: 99%

The Role of Osteopontin in Respiratory Health and Disease

Barkas

Kotsiou

2023

JPM

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The biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone disease. We aimed to present the role of OPN in respiratory health and disease. OPN influences the immune system and is a chemo-attractive protein correlated with respiratory disease severity. There is evidence that OPN can advance the disease stage associated with its fibrotic, inflammatory, and immune functions. OPN contributes to eosinophilic airway inflammation. OPN can destroy the lung parenchyma through its neutrophil influx and fibrotic mechanisms, linking OPN to at least one of the two major chronic obstructive pulmonary disease phenotypes. Respiratory diseases that involve irreversible lung scarring, such as idiopathic pulmonary disease, are linked to OPN, with protein levels being overexpressed in individuals with severe or advanced stages of the disorders and considerably lower levels in those with less severe symptoms. OPN plays a significant role in lung cancer progression and metastasis. It is also implicated in the pathogenesis of pulmonary hypertension, coronavirus disease 2019, and granuloma generation.

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“…In animal models of RA, targeting OPN with small interfering RNA (siRNA) or neutralizing antibodies to the relevant epitopes resulted in a significant inhibition of joint inflammation [ 26 , 27 ]. Recent works, including ours, demonstrated that epithelial-cell-derived osteopontin (OPN) plays a critical role in CRSwNP, AR, and allergic asthma [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Role and Clinical Relevance of Osteopontin in Allergic Airway Diseases

Liu

2023

JCM

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The airway epithelium is exposed to numerous external irritants including infectious agents, environmental allergens, and atmospheric pollutants, releasing epithelial cytokines including thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 and initiating downstream type 2 (IL-4, IL-13, and IL-5) and IgE-driven pathways. These pathways trigger the initiation and progression of allergic airway diseases, including chronic rhinosinusitis with nasal polyps (CRSwNP), allergic rhinitis (AR), and allergic asthma. However, the use of biological agents that target downstream cytokines, such as IL-5, IL-4, and IL-13 receptors and IgE, might not be sufficient to manage some patients successfully. Instead of blocking downstream cytokines, targeting upstream epithelial cytokines has been proposed to address the complex immunologic networks associated with allergic airway diseases. Osteopontin (OPN), an extracellular matrix glyco-phosphoprotein, is a key mediator involved in Th1-related diseases, including systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis. Emerging evidence, including ours, indicates that epithelial-cell-derived OPN also plays an essential role in Th2-skewed airway diseases, including CRSwNP, AR, and allergic asthma involving the Th17 response. Therefore, we reviewed the current knowledge of epithelial-cell-derived OPN in the pathogenesis of three type-2-biased airway diseases and provided a direction for its future investigation and clinical relevance.

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Osteopontin mediated eosinophils activation by group II innate lymphoid cells

Cited by 3 publications

References 23 publications

Immunoregulatory Roles of Osteopontin in Diseases

Immunoregulatory Roles of Osteopontin in Diseases

The Role of Osteopontin in Respiratory Health and Disease

The Role and Clinical Relevance of Osteopontin in Allergic Airway Diseases

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