Osteopontin: regulation in tumor metastasis

Wai, Philip Y.; Kuo, Paul C.

doi:10.1007/s10555-007-9104-9

Cited by 293 publications

(306 citation statements)

References 198 publications

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“…Elevated OPN expression is associated with advanced stage, tumor invasion, and metastasis in multiple cancers. The function of OPN is versatile and involves the induction of multiple signalling pathways (PI 3'-kinase/Akt, NF-kB) by integrin and CD44 receptors that mediate metastatic processes [8,18,19].…”

Section: Discussionmentioning

confidence: 99%

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The role of osteopontin expression in melanoma progression

et al. 2015

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It was shown that osteopontin (OPN), a glycophosphoprotein, plays divergent roles in cancer progression. In addition to multiple intra-and extracellular functions, it facilitates migration of tumor cells, has crucial role in cell adhesion and is associated with increased metastasis formation. In previous studies, we performed global gene-expression profiling on a series of primary melanoma samples and found that OPN was significantly overexpressed in ulcerated melanomas. The major purpose of this study was to define OPN expression in primary melanomas with differing biological behaviours. OPN mRNA expression was analysed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in primary melanoma tissues. Immunohistochemistry was performed using a tissue microarray. Cox regression tests were used for survival analysis. Greater than 50% of the tissues exhibited high protein expression that was significantly associated with tumor thickness and metastasis. OPN mRNA expression was significantly increased in thicker melanomas and lesions with an ulcerated surface. Increased expression was primarily detected in advanced-stage tumors. A multivariate Cox regression analysis revealed that high OPN expression, tumor thickness, and metastasis were significantly associated with reduced relapse-free survival. In summary, high OPN mRNA and protein expression were associated with a less favourable clinical outcome of primary melanoma patients. We determined that OPN is a significant predictive factor for the survival of primary melanoma patients. Based on our and others data the high expression of OPN may have a crucial stimulatory role in tumor progression and metastasis formation, thus, have been proposed as potential targets for cancer diagnosis and therapy.3

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Section: Discussionmentioning

confidence: 99%

“…Osteopontin (OPN) is a multifunctional extracellular matrix protein that is produced by numerous cell types [6][7][8][9][10][11]. OPN plays important roles in cancer cell adhesion, cell motility, and survival [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The role of osteopontin expression in melanoma progression

et al. 2015

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“…Les SIBLING pourraient jouer un rôle capital dans la formation des métastases car elles sont impliquées, comme décrit précédemment, dans l'adhésion cellulaire, la migration et la dégrada-tion de la matrice. Il a été démontré dans plusieurs études que l'OPN et la BSP jouent un rôle prométastatique (pour revue, voir [30]). Les tumeurs susceptibles d'évoluer vers un stade plus avancé présentent une expression de SIBLING augmentée ou apparaissant de novo.…”

Section: Formation De Métastasesunclassified

Les protéines SIBLING

et al. 2013

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“…These proteins are important players in cell-cell and cell-matrix communications. 7 Human OPN has a size of 314 amino acids, [8][9][10] but is detected in bands with apparent sizes of 41-75 kDa. This is due to different splice variants and intensive post-translational modifications.…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20][21][22][23] Interaction of OPN with avb3 integrin also alters the host immunity by increasing cytokine expression 24,25 and enhances angiogenic functions through avb3-integrinmediated activation of endothelial cells. 7,[26][27][28] In view of these important tumor progressive functions, Opn represents a potential therapeutic target for the modulation of tumor progression and metastasis formation. Therefore, it was the aim of this study to silence Opn expression by an antisense-oligomer in CC531 lacZ rat colorectal cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Influence of osteopontin expression on the metastatic growth of CC531 rat colorectal carcinoma cells in rat liver

et al. 2011

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Development of hepatic metastasis is responsible for most of colorectal cancer-related deaths. Osteopontin (OPN) is a small integrin-binding N-linked glycoprotein, which plays a crucial role in the formation of hepatic metastasis. This study aimed to suppress Opn expression by an antisense-oligonucleotide (ASO Opn ) to decrease liver metastasis in vivo. The effect of ASO Opn was investigated in vitro in CC531 lacZ colorectal cancer cells in comparison to sense (SO) or nonsense (NSO) oligomers, by determining mRNA and protein expression levels, as well as cell survival. For in vivo treatment, CC531 lacZ cells were intraportally inoculated into rats to compare the effects of ASO, SO and NSO oligomers, following prolonged subcutaneous administration by osmotic minipumps. The resulting CC531 lacZ tumor cell load in the liver was measured by a b-galactosidase assay. Proliferation of CC531 lacZ cells in vitro was significantly decreased after ASO Opn and SO treatment (Po0.001). Liver metastasis development was reduced as long as ASO Opn was administered, but this effect was rapidly blunted following the end of the ASO Opn administration. In contrast, administration of the SO resulted in a tumor load reduction, which surprisingly surpassed the ASO Opn effect in vivo in terms of a long-lasting metastasis suppression, which was accompanied with increased survival of the animals. Administration of the ASO Opn in rats was effective in decreasing their liver metastasis. The short-lived effect might be extended by modifications suited to increase the ASOs' half-life. In addition, there was a superior anti-metastatic effect caused by the SO, which has not been reported previously.

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Osteopontin: regulation in tumor metastasis

Cited by 293 publications

References 198 publications

The role of osteopontin expression in melanoma progression

The role of osteopontin expression in melanoma progression

Les protéines SIBLING

Influence of osteopontin expression on the metastatic growth of CC531 rat colorectal carcinoma cells in rat liver

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