Osteopontin/SPP1: a potential mediator between immune cells and vascular calcification

Zhao, Yanli; Huang, Zujuan; Gao, Limei; Ma, Hongbo; Chang, Rong

doi:10.3389/fimmu.2024.1395596

Cited by 3 publications

References 156 publications

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Multi-omics identification of extracellular components of the fetal monkey and human neocortex

Vilicich,

Vettiatil,

Kattapong-Graber

et al. 2024

Preprint

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During development, precursor cells are continuously and intimately interacting with their extracellular environment, which guides their ability to generate functional tissues and organs. Much is known about the development of the neocortex in mammals. This information has largely been derived from histological analyses, heterochronic cell transplants, and genetic manipulations in mice, and to a lesser extent from transcriptomic and histological analyses in humans. However, these approaches have not led to a characterization of the extracellular composition of the developing neocortex in any species. Here, using a combination of single-cell transcriptomic analyses from published datasets, and our proteomics and immunohistofluorescence analyses, we provide a more comprehensive and unbiased picture of the early developing fetal neocortex in humans and non-human primates. Our findings provide a starting point for further hypothesis-driven studies on structural and signaling components in the developing cortex that had previously not been identified.

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Multi-omics identification of extracellular components of the fetal monkey and human neocortex

Vilicich,

Vettiatil,

Kattapong-Graber

et al. 2024

Preprint

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Is Osteopontin a Reliable Biomarker for Endometriosis?

Zygula,

Kiecka,

Sankiewicz

et al. 2024

IJMS

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This study aimed to evaluate the concentration of osteopontin in peritoneal fluid and plasma as potential biomarkers for diagnosing endometriosis. Osteopontin levels were measured using surface plasmon resonance imaging (SPRI) biosensors in patients suspected of having endometriosis. Plasma samples were collected from 120 patients, and peritoneal fluid was collected from 86 patients. Based on the detection of endometriosis lesions during laparoscopy, participants were divided into a study group (patients with endometriosis) and a control group (patients without endometriosis). The results showed no significant differences in plasma osteopontin levels between women with endometriosis and the control group (19.86 ± 6.72 ng/mL vs. 18.39 ± 4.46 ng/mL, p = 0.15). Similarly, peritoneal fluid osteopontin concentrations did not differ significantly between patients with and without endometriosis (19.04 ± 5.37 ng/mL vs. 17.87 ± 5.13 ng/mL, p = 0.29). Furthermore, osteopontin levels in both plasma and peritoneal fluid were not significantly associated with the stage of endometriosis, the presence of endometrioma, or the menstrual cycle phase. The findings of this study do not support osteopontin concentration as a reliable biomarker for endometriosis. However, further research is necessary to explore osteopontin’s potential role in the disease.

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Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)

Sun,

2024

Exp Ther Med

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Stroke, including hemorrhagic stroke and ischemic stroke, is a common disease of the central nervous system. It is characterized by a high mortality and disability rate and is closely associated with atherosclerosis, hypertension hyperglycemia, atrial fibrillation and unhealthy living habits. The continuous development of surgery and medications has decreased the mortality rate of patients with stroke and has greatly improved the disease prognosis. At present, the direction of clinical treatment and research has gradually shifted to the repair of nerve function after stroke. Osteopontin (OPN) is a widely distributed extracellular matrix protein. Due to its structural characteristics, OPN can be cut and modified into terminal fragments with different functions, which play different roles in various pathophysiological processes, such as formation of tumors, inflammation and autoimmune diseases. It has also become a potential diagnostic and therapeutic marker. In order to comprehensively analyze the specific role of OPN in nerve repair and its relationship with stroke and stroke-related diseases, the following key words were used: ‘Osteopontin, stroke, atherosis, neuroplasticity, neural repair’. PubMed, Web of Science and Cochrane articles related to OPN were searched and summarized. The present review describes the OPN structure, isoforms, functions and its neural repair mechanism, and its association with the occurrence and development of stroke and related diseases was explored.

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Osteopontin/SPP1: a potential mediator between immune cells and vascular calcification

Cited by 3 publications

References 156 publications

Multi-omics identification of extracellular components of the fetal monkey and human neocortex

Multi-omics identification of extracellular components of the fetal monkey and human neocortex

Is Osteopontin a Reliable Biomarker for Endometriosis?

Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)

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