Osteoporosis - An Update

Lamichhane, Arjun

doi:10.31729/jnma.404

Cited by 30 publications

(22 citation statements)

References 20 publications

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“…In our series and in others, there was no significant relationship between older age and BMD (Voskaridou et al , 2006). Our SCD patients seemed to develop abnormal BMD shortly after the normal population acquires peak bone mass (Lamichhane, 2005). This observation of young adults with abnormal BMD could simply be the result and continuum of what is seen in SCD children and adolescents (Brinker et al , 1998; Soliman et al , 1998; VanderJagt et al , 2002; Lal et al , 2005).…”

Section: Discussionmentioning

confidence: 99%

“…The World Health Organization (WHO) defined osteopenia as a BMD value between 2·5 and 1·5 standard deviations (SD) below the young adult mean at one or more sites (T‐score) and osteoporosis as 2·5 SD below this norm (Bohannon, 1999; Gutherie et al , 2000; Lamichhane, 2005; Lane, 2006). DXA reports from three different anatomical sites (femoral neck, lumbar spine and ultra distal region of the radius.)…”

Section: Methods and Populationmentioning

confidence: 99%

“…Many authors agree that SCD patients are more likely to be osteopenic and osteoporotic (Brinker et al , 1998; Soliman et al , 1998; VanderJagt et al , 2002; Nelson et al , 2003; Lal et al , 2005; Miller et al , 2006; Voskaridou et al , 2006). The present study aimed to establish the prevalence of low bone mass in patients with SCD and examined some predisposing factors (Gutherie et al , 2000; Olszynski et al , 2004; Lamichhane, 2005; Templeton, 2005; Lane, 2006).…”

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confidence: 99%

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Bone mass density in adults with sickle cell disease

et al. 2007

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Summary Sickle cell disease (SCD) leads to many complications including osteoporosis and osteopenia. We studied the prevalence and predisposing factors of low bone mass density (BMD) in adults with SCD. In this retrospective study, dual X‐ray absorptiometry bone scans were used to determine BMD in the lumbar spine, femoral neck and ultra distal radius of 103 patients (73 females, 30 males, aged 15–80 years). Chart reviews and a patient questionnaire were used to collect patient characteristics, disease course and severity, and low BMD risk factors. The 79·6% of patients (mean age 36·5 ± 12·5 years) had an abnormal BMD, with a predilection for the lumbar spine (P = 0·001). Analysis by 3 (low BMD versus very low BMD versus normal) or by 2 groups (abnormal versus normal) showed that abnormal BMD was associated with lower body mass index (BMI) (P = 0·003), lower Hb level (P = 0·001) and higher ferritin (P = 0·003). Low BMD patients were more likely to be SS, SC or Sβ0thal than Sβ+thal (P = 0·022). Abnormal BMD was not related to age, sex, menarche, SCD complications, number of crises, iron overload, treatment with hydroxycarbamide or desferal, renal disease, smoking or alcohol. Patients treated with hydroxycarbamide for at least 6 months were more likely to have an abnormal BMD. In this SCD population, abnormal BMD seemed to be independent of sex, age and menopause, whereas BMI, ferritin level, Hb type and level appeared to play a major role.

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Section: Discussionmentioning

confidence: 99%

Section: Methods and Populationmentioning

confidence: 99%

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confidence: 99%

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Bone mass density in adults with sickle cell disease

et al. 2007

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“…The bone mineral density (BMD) peaks at about 35-years of age and then begins to decline with advancing age. Significant deceleration of BMD is seen in females after menopause 20 . These conditions increases bone fragility and risk of pathological fractures especially of hips and spine thereby compromising quality of life if the fracture occurs.…”

Section: Discussionmentioning

confidence: 98%

Non-communicable disease pattern in adults seeking preventive general health checkup

et al. 2019

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Non Communicable diseases (NCDs) are now endemic in low and middle income countries. Nepal had a high burden of communicable diseases (CDs) which has now been overtaken by NCDs. Although prevention and control of NCDs is prioritized in national policies and strategies, there is no proper monitoring system. This study aims to review the morbidity pattern among the adults seeking preventive general health checkup in a major tertiary care hospital in Kathmandu. 3000 cases were evaluated. 53.6% were males and 46.4% were females. The mean age of cases was 44.9 yrs. Most of the cases ranged from 40 to 60 years of age. Almost half of them were from Kathmandu district. Nearly 78% participants live a sedentary life. Abdominal obesity was seen in 27.5% of females and 21.7% of males. Nearly 49% of cases were overweight and 24% were obese. Almost 21 % of the cases were smokers and about 36% of them consumed alcohol. Only 9% are vegetarians. 10% have diabetes and 20% have hypertension. 69% of females and 43% of males have less than normal bone mineral density. The government and private sectors must focus on strengthening preventive and curative services for early detection of risk factors and management of NCDs.

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“…It is widely accredited that osteoporosis is related to individual genetic differences, estrogen levels, nutritional status and lifestyle. In addition, osteoporosis can also be induced by bone formation and bone resorption disorder caused by physical injury, diseases affecting bone metabolism, or long-term use of hormone drugs 4 . The interaction between vitamin D and its receptor exerts an important role in calcium homeostasis and bone metabolism by regulating osteocyte growth and differentiation, intestinal calcium absorption and parathyroid hormone secretion 5 .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Bsm I Polymorphism and Osteoporosis Risk in postmenopausal women: A Meta-Analysis from 42 Studies

Liao

Qin

Zhou

et al. 2020

Preprint

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Objective: This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and Methods: The PubMed, EMBASE, Weipu, CNKI, and Wanfang database were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results: 4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR=0.809, 95% CI 0.678~0.965, p=0.019, recessive model: OR=0.736, 95% CI 0.568~0.955, p=0.021, and co-dominant model: bb vs. BB OR=0.701, 95% CI 0.511~0.962 p= 0.028), and we failed to find any significant relationship in Asians. Conclusion: The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis.

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Osteoporosis - An Update

Cited by 30 publications

References 20 publications

Bone mass density in adults with sickle cell disease

Bone mass density in adults with sickle cell disease

Non-communicable disease pattern in adults seeking preventive general health checkup

Vitamin D Receptor Bsm I Polymorphism and Osteoporosis Risk in postmenopausal women: A Meta-Analysis from 42 Studies

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