Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence – a multi-centre study

Otto, Sven; Abu-Id, Mario Hakim; Fedele, Stefano; Warnke, Patrick H.; Becker, Stephan; Kolk, Andreas; Mücke, Thomas; Mast, Gerson; Köhnke, Robert; Volkmer, Elias; Haasters, Florian; Lieger, Olivier; Iizuka, Tetsuya; Porter, Stephen; Campisi, Giuseppina; Colella, Giuseppe; Ploder, Oliver; Neff, Andreas; Wiltfang, Jens; Ehrenfeld, Michael; Kreusch, Thomas; Wolff, Klaus‐Dietrich; Stürzenbaum, Stephen R.; Schieker, Matthias; Pautke, Christoph

doi:10.1016/j.jcms.2010.05.009

Cited by 123 publications

(79 citation statements)

References 53 publications

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“…These findings are compatible with those of previously reported studies. 28,29 However, the positive association between the oral administration of BPs and a positive surgical outcome disagrees somewhat with previous reports based on smaller samples. 17 Surgical outcome also appears to be influenced by corticosteroid therapy.…”

Section: Discussioncontrasting

confidence: 85%

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Graziani

Vescovi

Campisi

et al. 2012

Journal of Oral and Maxillofacial Surgery

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117

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Purpose:The aim of this study was to evaluate the results of the surgical treatment of bisphosphonaterelated osteonecrosis of the jaw (BRONJ) in a large cohort. Materials and Methods: A retrospective cohort multicenter study was designed. Patients were enrolled if they were diagnosed with BRONJ and received operative treatment. Data on demographic, health status, perioperative, and surgical factors were collected retrospectively. The primary outcome variable was a change in BRONJ staging (improvement, worsening, or no change). Interventions were grouped by local debridement and resective surgery. Data were collected for other variables as cofactors. Univariate analysis and logistic regressions were then performed. Results: Of the 347 BRONJ-affected subjects, 59% showed improvement, 30% showed no change, and 11% showed worsening. Improvement was observed in 49% of cases treated with local debridement and 68% of cases treated with resective surgery. Multivariate analysis indicated that maxillary location, resective surgery, and no additional corticosteroid treatment were associated with a positive outcome. Conclusions: Surgical treatment of BRONJ appeared to be more effective when resective procedures were performed. Nonetheless, other factors, such as the absence of symptoms and the types of drug administration, should be taken into account before clinical decisions are made.

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Section: Discussioncontrasting

confidence: 85%

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Graziani

Vescovi

Campisi

et al. 2012

Journal of Oral and Maxillofacial Surgery

Self Cite

117

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“…Less uniform is the percentage of BRONJ among non-cancer, osteoporotic patients within whole samples also comprising cancer patients: in a multi-center study, a BRONJ frequency of 7.1% in patients treated with oral BP therapy [41] was reported; a frequency of 8.9% of BRONJ after per os BP administration was observed in two Israeli medical centers; and, of all the BRONJ patients in other case series reported in the literature, the percentage of orally-administered bisphosphonate-induced ONJ ranges from 2.5% to 27.3% [58]. In the absence of reliable statistics indicating the number of patients exposed to BPs, it is still not easy to establish the real risk of developing BRONJ for non-cancer patients, also due to the large number of supposed and still unascertained risk factors.…”

Section: European Journal Of Internal Medicine 24 (2013) 784-790mentioning

confidence: 99%

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

Fede

Fusco

Matranga

et al. 2013

European Journal of Internal Medicine

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“…4,5,8,9 Osteonecrosis of the jaw has also been reported as a result of prolonged bisphosphonate therapy. 10 We present a case study of a patient who had alendronate-associated bilateral subtrochanteric femoral stress fractures that went untreated until the patient suffered a complete fracture in the subtrochanteric region of the right femur. A retrospective review of previous emergency department (ED) visits and imaging demonstrate the characteristic presentation of femoral stress fractures associated with bisphosphonate use.…”

Section: -3mentioning

confidence: 99%

Signs of Insufficiency Fractures Overlooked in a Patient Receiving Chronic Bisphosphonate Therapy

Shaikh

Morris

2016

The Journal of the American Board of Family Medicine

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Chronic bisphosphonate therapy is associated with atypical fractures of the subtrochanteric and proximal femoral diaphyseal regions. Various radiologic imaging signs can identify bisphosphonate-associated stress fractures before they progress to complete fractures. Identifying patients who are at risk and modifying treatment can prevent these fractures from occurring. We present a case study of a patient taking bisphosphonate with 2 years of chronic pain, and characteristic clinical signs of bisphosphonateassociated incomplete stress fractures that went untreated until the patient suffered from a right subtrochanteric complete fracture. Our goal is to make physicians aware of the signs of insufficiency fractures associated with chronic bisphosphonate therapy such that appropriate clinical decisions are made to optimize the quality of patient care.

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Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence – a multi-centre study

Cited by 123 publications

References 53 publications

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

Signs of Insufficiency Fractures Overlooked in a Patient Receiving Chronic Bisphosphonate Therapy

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