Osteoporosis and osteoarthritis

Geusens, Piet; Bergh, Joop van den

doi:10.1097/bor.0000000000000256

Cited by 73 publications

(38 citation statements)

References 49 publications

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“…Except for the small sample size, a plausible scenario could be in the follows. OA is an age strongly-related degenerative disease, and BMI has opposing effect on OA and OP; also, local in ammation caused by mechanical injury, rather than systemic one caused by autoimmunology, is its salient feature 36 . Whether pSS would gain higher prevalence of OP or osteopenia is still uncertain 12 and in present study were mostly in early-onset and untreated.…”

Section: Prevalence Of Bone Loss and Odd Ratiosmentioning

confidence: 99%

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

Yang

et al. 2020

Preprint

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Abstract Objectives: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.Method: A cross-sectional study recruits 1,398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P<0.001) and SLE (39.6%, P=0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P<0.001), OA (P=0.02) and SLE (P =0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

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Section: Prevalence Of Bone Loss and Odd Ratiosmentioning

confidence: 99%

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

Yang

et al. 2020

Preprint

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“…1 Hazard ratio for femur neck and trochanteric fracture before and after total knee replacement (TKR), adjusted for age, gender, calendar year, and latitude Table 3 The hazard ratios (with 95% CI) for hip fracture before and after total knee replacement (TKR), according to age, compared to individuals without TKR [25]. Women and men with osteoarthritis tend to have a higher BMI [11,13]. Obese individuals tend to have increased BMD but are also associated with a lower rate of bone formation [10].…”

Section: Bmd Bmi Falls and Fracturementioning

confidence: 99%

“…Several studies have reported an association between high bone mineral density (BMD) and osteoarthritis [10]. In contrast, other reports infer that both women and men with osteoarthritis also may have osteoporosis or osteopenia [11,12] and an increased risk of falls and fracture [10,11,13].…”

Section: Introductionmentioning

confidence: 99%

Risk for hip fracture before and after total knee replacement in Sweden

et al. 2019

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We studied the risk for hip fracture before and after total knee replacement (TKR) in the entire population in Sweden. Women and men had a low risk for hip fracture before TKR but an increased risk the first year after TKR. Purpose It is known that osteoarthritis is associated with high bone mass. We therefore studied the risk of hip fracture before and after total knee replacement (TKR), risk of different hip fracture types, and risk subdivided in genders and age groups. Methods We followed the total Swedish population born between 1902 and 1952 (n = 4,258,934) during the period 1987-2002 and identified all patients with TKR due to primary OA (n = 39,291), and all patients with hip fracture (n = 195,860) in the Swedish National Inpatient Register. The risk time analyses were based on Poisson regression models. Results The hazard ratio (HR) for hip fracture the last year before TKR was 0.86 (95% CI 0.74 to 1.00) and the first year after 1.26 (95% CI 1.11 to 1.42) compared to individuals without TKR. The HR for femoral neck fracture 0-10 years after TKR was 0.95 (95% CI 0.89 to 1.01) and for trochanteric fracture was 1.13 (95% CI 1.06 to 1.21). The HR for hip fracture in the age group 50-74 was 1.28 (95% CI 1.14 to 1.43) and in the age group 75-90 years was 0.99 (95% CI 0.94 to 1.04) 0-10 years after TKR, compared to individuals without TKR. Conclusion Individuals had a low risk for hip fracture before TKR but an increased risk the first year after TKR. The risk in individuals below age 75 years and for trochanteric fractures was increased after TKR. Possible explanations include changed knee kinematics after a TKR, physical activity level, fall risk, and other unknown factors.

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“…It affects about one third of women and one fifth of men aged 50 years and older in the United States 45 . Although osteoarthritis and osteoporosis are traditionally viewed to have an inverse relationship 46 , contemporary understanding of both diseases recognize different disease phenotypes, including the presence of osteoporotic, erosive and bone-forming osteoarthritis phenotypes 46–49 . Indeed, several studies found a high prevalence of osteoporosis in THA and TKA patients 50–53 .…”

Section: Comorbiditiesmentioning

confidence: 99%

Clinical Factors, Disease Parameters, and Molecular Therapies Affecting Osseointegration of Orthopedic Implants

et al. 2016

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Total hip and knee arthroplasty are effective interventions for management of end-stage arthritis. Indeed, about 7 million Americans are currently living with artificial hip and knee joints. The majority of these individuals, however, will outlive their implants and require revision surgeries, mostly due to poor implant osseointegration and aseptic loosening. Revisions are potentially avoidable with better management of patient-related risk factors that affect the osseointegration of orthopedic implants. In this review, we summarize the published clinical literature on the role of demographics, biologic factors, comorbidities, medications and aseptic loosening risk. We focus on several systemic and local factors that are particularly relevant to implant osseointegration. Examples include physiological and molecular processes that are linked to hyperglycemia, oxidative stress, metabolic syndrome and dyslipidemia. We discuss how orthopedic implant osseointegration can be affected by a number of molecular therapies that are antiresorptive or bone anabolic (i.e. calcium, vitamin D, bisphosphonates, calcitonin, strontium, hormone replacement therapy, selective estrogen-receptor modulators).

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Osteoporosis and osteoarthritis

Cited by 73 publications

References 49 publications

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

Risk for hip fracture before and after total knee replacement in Sweden

Clinical Factors, Disease Parameters, and Molecular Therapies Affecting Osseointegration of Orthopedic Implants

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