Saudi investigations reported that the application of preventive approaches to limit the spread of osteoporosis is poor. This indicates the importance of nationwide investigations to stress the importance of the adequate implementation of preventive measures. A thorough electronic search of a wide range of databases was conducted to identify all the relevant cross-sectional studies reporting knowledge, awareness and practice among Saudi population, with no time limitations. A total of 25 prospective cross-sectional studies that were conducted in Saudi Arabia were included and were published between 2010 and 2021. Most of these studies were conducted in Riyadh, however, other regions such as Bisha, Qassim, Taif, Al-Hassa, Alahsa, Jazan, and nationwide can also be found in our included studies. The sample size was hugely variable and ranged between 43 and 1,830, with a total of 12,407 individuals. Among the included studies, 11 included female populations only, 3 included healthcare workers only, and the rest included mixed populations.Most of the included studies had good awareness levels regarding osteoporosis. Moreover, we also found that age, gender, education level, and socio-economic status are common factors that may impact the level of knowledge and awareness across the different studies, although some studies reported the non-significance of these variables.Further education campaigns are still needed to further enhance levels of awareness of other factors than the ones reported.