Osteoporosis-associated Fracture and Diabetes

Kurra, Salila; Fink, Dorothy A.; Siris, Ethel S.

doi:10.1016/j.ecl.2013.09.004

Cited by 100 publications

(67 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13 Many comparative studies of bone regeneration and implants are based on their stability. 28,29 In a study by Deli et al, 30 implants placed in sites of bone regeneration were found to offer less stability. However, stability is not the only implant characteristic examined in relation to bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Osteoporosis and Marginal Bone Loss in Osseointegrated Implants: A 2‐Year Retrospective Study

Corcuera-Flores

Alonso-Domínguez

Serrera-Figallo

et al. 2016

Journal of Periodontology

View full text Add to dashboard Cite

Background: Fitting implants in osteoporotic patients has traditionally been controversial, and there is little scientific evidence relating osteoporosis to marginal bone loss (MBL). The aims of this study are as follows: 1) to evaluate the possibility of a correlation between osteoporosis, as measured by the mandibular cortical index (MCI), and MBL and 2) to assess how various systemic diseases, periodontitis, and placement of implants in regenerated bone are correlated with MBL and MCI.Methods: This retrospective study examines 212 implants inserted in 67 patients. To take a possible cluster failure into account, an implant for each patient was selected (n = 67 implants). MBL was assessed. Osteoporosis was evaluated using the MCI. Both MBL and MCI were assessed from panoramic radiographs. x 2 test was performed (Haberman post hoc test). Significance was P <0.05.Results: When the total sample implant (N = 212) was evaluated, a significant association was found between the presence of osteoporosis and MCI (P <0.001) and between the presence of diabetes mellitus and MCI (P <0.01). Significant associations were also found between MBL and placement of implants in regenerated sites (P <0.001) and between MBL and a previous history of periodontitis (P <0.05). When the sample is evaluated only in selected implants (one per patient, n = 67), significant differences appear to relate only to the MBL with the placement of implants in regenerated bone sites (P <0.001).Conclusions: Osteoporosis (as evaluated by MCI) does not pose a risk for the development of greater MBL. Parameters adversely affecting the development of increased MBL are a previous history of periodontitis and especially the placement of implants at sites of bone regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship Between Osteoporosis and Marginal Bone Loss in Osseointegrated Implants: A 2‐Year Retrospective Study

Corcuera-Flores

Alonso-Domínguez

Serrera-Figallo

et al. 2016

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…DM has been associated with long-term damage, dysfunction and failure of various organs, as well as retinopathy, nephropathy, peripheral neuropathy and sexual dysfunction 2 . It has been reported that the DM causes a series of complications on bone metabolism, resulting in osteopenia and significant loss of bone density 3 . Thus, DM impacts negatively on bone repair in response to imbalance between bone formation and resorption, as well as on the dynamics of the inflammatory 4 .…”

Section: Introductionmentioning

confidence: 99%

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Nascimento

Almeida

Cunha³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

Brazil. Design of the study, histological examinations, manuscript writing, supervised all phases of the study. ABSTRACT PURPOSE:To investigate the effect of low-level laser therapy on bone healing in diabetic rats. METHODS:Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed. RESULTS:Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05). CONCLUSION:Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxaninduced diabetic rats.

show abstract

“…There is a lot of evidence that demonstrate both types of diabetes have a negative effect on bone strength and both types are associated with an increased risk of fracture [4, 5, 108]. We might suggest that among mechanisms explored in this paper, the hyperglycemia and AGEs have more prominent role [9].…”

Section: Discussionmentioning

confidence: 92%

“…Diabetes-induced changes in metabolism significantly affect the bone metabolism and increase the risk of fracture by six times in type 1 and by 2 times in type 2 diabetic patients [3]. Although many studies have shown the negative effects of diabetes on the bone quality and strength, the debate is still open [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Mechanisms involved in altered bone metabolism in diabetes: a narrative review

Ghodsi

Larijani

Keshtkar

et al. 2016

J Diabetes Metab Disord

View full text Add to dashboard Cite

Many studies have shown that change in metabolism caused by diabetes can influence the bone metabolism in a way that quality and strength of bone is decreased. A 6 times and 2 times increased risk of fracture is reported in patients with type 1 and type 2 diabetes, respectively. There are several mechanisms by which diabetes can affect the bone. The fact that some of these mechanisms are acting in opposite ways opens the door for debate on pathways by which diabetes affects the bones. On the other hand, bone is not a simple organ that only get influence from other organs, but it is an endocrine organ that by secreting the agents such as osteocalcin, adiponectin and visfatin which can affect the insulin sensitivity and metabolism. In this paper we tried to briefly assess the latest finding in this matter.

show abstract

Osteoporosis-associated Fracture and Diabetes

Cited by 100 publications

References 56 publications

Relationship Between Osteoporosis and Marginal Bone Loss in Osseointegrated Implants: A 2‐Year Retrospective Study

Relationship Between Osteoporosis and Marginal Bone Loss in Osseointegrated Implants: A 2‐Year Retrospective Study

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Mechanisms involved in altered bone metabolism in diabetes: a narrative review

Contact Info

Product

Resources

About