Osteoporosis, fracture, osteoarthritis &amp; sarcopenia: A systematic review of circulating microRNA association

Jones, Tania; Esa, Mohammed S.; Li, K.H. Christien; Krishnan, Subha; Elgallab, George M.; Pearce, Mark; Young, David A.; Birrell, Fraser

doi:10.1016/j.bone.2021.116068

Cited by 28 publications

(25 citation statements)

References 108 publications

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“…As well as providing the ability to study changes within a tissue in response to injury, in vivo models can also enable identification of circulating factors that alter as a result of injury and are therefore potential biomarkers of disease. It is increasingly recognised that circulating non-coding RNAs (ncRNAs) are promising biomarkers for a range of musculoskeletal diseases, including osteoarthritis and osteoporosis [28,29]. However, to the authors' knowledge, only one previous study has attempted to establish if circulating ncRNAs can be used as biomarkers of tendon injury, demonstrating unique serum microRNA (miRNA) signatures in human rotator cuff tendinopathy and tears [30], and no studies have characterised circulating ncRNAs in animal models of tendon injury…”

Section: Introductionmentioning

confidence: 99%

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4

Marr

Meeson

Kelly

et al. 2021

IJMS

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The interfascicular matrix (IFM) binds tendon fascicles and contains a population of morphologically distinct cells. However, the role of IFM-localised cell populations in tendon repair remains to be determined. The basement membrane protein laminin-α4 also localises to the IFM. Laminin-α4 is a ligand for several cell surface receptors, including CD146, a marker of pericyte and progenitor cells. We used a needle injury model in the rat Achilles tendon to test the hypothesis that the IFM is a niche for CD146+ cells that are mobilised in response to tendon damage. We also aimed to establish how expression patterns of circulating non-coding RNAs alter with tendon injury and identify potential RNA-based markers of tendon disease. The results demonstrate the formation of a focal lesion at the injury site, which increased in size and cellularity for up to 21 days post injury. In healthy tendon, CD146+ cells localised to the IFM, compared with injury, where CD146+ cells migrated towards the lesion at days 4 and 7, and populated the lesion 21 days post injury. This was accompanied by increased laminin-α4, suggesting that laminin-α4 facilitates CD146+ cell recruitment at injury sites. We also identified a panel of circulating microRNAs that are dysregulated with tendon injury. We propose that the IFM cell niche mediates the intrinsic response to injury, whereby an injury stimulus induces CD146+ cell migration. Further work is required to fully characterise CD146+ subpopulations within the IFM and establish their precise roles during tendon healing.

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Section: Introductionmentioning

confidence: 99%

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4

Marr

Meeson

Kelly

et al. 2021

IJMS

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“…characterised circulating microRNAs from the plasma of patients with early and late radiographic KOA, identifying a panel of microRNAs which differentiated between the two groups 56 . This adds to a small number of studies which have assessed circulating microRNAs in OA, but there currently appears little consensus in the microRNAs identified, potentially owing to differences in patient cohorts, study design and technological methodology utilized 57 .…”

Section: Epigeneticsmentioning

confidence: 99%

Osteoarthritis year in review: genetics, genomics, epigenetics

Young

Barter

Soul

2022

Osteoarthritis and Cartilage

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Summary Objective In this review, we have highlighted the advances over the past year in genetics, genomics and epigenetics in the ﬁeld of osteoarthritis (OA). Methods A literature search of PubMed was performed using the criteria: “osteoarthritis” and one of the following terms “genetic(s), genomic(s), epigenetic(s), polymorphism, noncoding ribonucleic acid (RNA), microRNA, long noncoding RNA, lncRNA, circular RNA, RNA sequencing (RNA-seq), single cell sequencing, transcriptomics, or deoxyribonucleic acid (DNA) methylation between April 01, 2020 and April 30, 2021. Results In total we identiﬁed 765 unique publications, which eventually reduced to 380 of relevance to the field as judged by two assessors. Many of these studies included multiple search terms. We summarised advances relating to genetics, functional genetics, genomics and epigenetics, focusing on our personal key papers during the year. Conclusions This year few studies have identiﬁed new genetic variants contributing to OA susceptibility, but a focus has been on refining risk loci or their functional validation. The use of new technologies together with investigating the cross-talk between multiple tissue types, greater sample sizes and/or better patient classification (OA subtypes) will continue to increase our knowledge of disease mechanisms and progress towards understanding and treating OA.

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“…In the past few years, several reports have shown that the altered expression of miRNAs contributes to the development of a wide range of human pathologies, and hence these tiny molecules have a remarkable potential to be used both as biomarkers and therapeutic targets for human illnesses, such as cancer, diabetes, chronic pediatric diseases, parasitic diseases, child neuropsychiatric disorders, hair loss disorders, cardiovascular diseases, and COVID-19 [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. In this context, different studies have been conducted to understand the roles of miRNAs in the development of bones and their association with the progression of bone diseases [ 17 , 18 , 19 , 20 ]. For instance, the most common miRNAs related to osteoblast functions during postnatal skeletal development are miR-34, miR-182, miR-199, miR-214, and miR-2861 [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential

et al. 2021

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MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments.

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Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association

Cited by 28 publications

References 108 publications

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4

Osteoarthritis year in review: genetics, genomics, epigenetics

The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential

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