Osteoporosis, frailty and fracture: implications for case finding and therapy

Bergh, Joop van den; Geel, Tineke van; Geusens, Piet

doi:10.1038/nrrheum.2011.217

Cited by 143 publications

(109 citation statements)

References 92 publications

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“…Osteoporosis is likely the result of osteoclastic deposition rather than osteoblastic defects (3,4). Therefore, in order to determine whether mobilization of AMD3100 affected osteoclast differentiation, we first examined HSPCs differentiation into mature functional osteoclasts by treatment with AMD3100 (17).…”

Section: Resultsmentioning

confidence: 99%

“…Destruction of this balance may lead to the development of bone disease, such as osteoporosis, which is characterized clinically by low bone density and a consequent increase in the risk of fracture, and pathologically by a decrease in bone mineral density (BMD) and an increase in osteoclastic bone resorption (3,4). Osteoclasts are somatic cells that differentiate from hematopoietic stem/progenitor cells (HSPCs) (5).…”

Section: Introductionmentioning

confidence: 99%

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AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells

Min¹,

Hwan²

2016

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Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained. Here we demonstrate the therapeutic effect of AMD3100 in the treatment of ovariectomy-induced osteoporosis in mice. We found that treatment with AMD3100 resulted in direct induction of release of SDF-1 from BM to blood and mobilization of hematopoietic stem/progenitor cells (HSPCs) in an osteoporosis model. AMD3100 prevented bone density loss after ovariectomy by mobilization of HSPCs, suggesting a therapeutic strategy to reduce the number of osteoclasts on bone surfaces. These findings support the hypothesis that treatment with AMD3100 can result in efficient mobilization of HSPCs into blood through direct blockade of the SDF-1/CXCR4 interaction in BM and can be considered as a potential new therapeutic intervention for osteoporosis. [BMB Reports 2014; 47(8): [439][440][441][442][443][444]

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells

Min¹,

Hwan²

2016

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“…Frailty can increase the severity of incidental fractures and mortality. A systematic review relating to frailty and fractures determined that the absolute risk of incidental fractures and mortality are significantly higher in frail people [15].…”

Section: Frailty and Fallsmentioning

confidence: 99%

Understanding Clinical Importance of Frailty and Designing a Frailty Assessment Tool in Acute Hospitals

Mt¹,

Yp²,

Chamberlain³

et al. 2014

J Gerontol Geriatr Res

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Introduction: Managing the acute admission of older patients is a challenge in hospitals. Frail older people represent a larger proportion of acute admissions. Length of inpatient stay, inpatient mortality and the 90-day readmission rate are significant in this group of patients. In order to reduce the risks of adverse outcomes, frailty should be screened using an appropriate assessment tool and these patients must receive a Comprehensive Geriatric Assessment (CGA).

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“…Consequently, available QUS approaches are typically used only as a pre-screening method, requiring a further DXA verification before taking therapeutic decisions (25,27). In this context, diagnosis and management of osteoporosis are routinely based on DXA outcomes and evaluation of clinical risk factors (e.g., presence of a previous fragility fracture), resulting in the reported evidence of underdiagnosis and undertreatment (30,31). In order to improve this situation, researchers in this field have recently turned their attention to the investigation of US approaches for osteoporosis diagnosis directly applicable on proximal femur and/or lumbar spine (32)(33)(34).…”

Section: New Perspectives In Echographic Diagnosis Of Osteoporosis Onmentioning

confidence: 99%

New perspectives in echographic diagnosis of osteoporosis on hip and spine

Casciaro

Conversano

Pisani

et al. 2015

ccmbm

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SummaryCurrently, the accepted "gold standard" method for bone mineral density (BMD) measurement and osteoporosis diagnosis is dual-energy X-ray absorptiometry (DXA). However, actual DXA effectiveness is limited by several factors, including intrinsic accuracy uncertainties and possible errors in patient positioning and/or post-acquisition data analysis. DXA employment is also restricted by the typical issues related to ionizing radiation employment (high costs, need of dedicated structures and certified operators, unsuitability for population screenings). The only commercially-available alternative to DXA is represented by "quantitative ultrasound" (QUS) approaches, which are radiation-free, cheaper and portable, but they cannot be applied on the reference anatomical sites (lumbar spine and proximal femur). Therefore, their documented clinical usefulness is restricted to calcaneal applications on elderly patients (aged over 65 y), in combination with clinical risk factors and only for the identification of healthy subjects at low fracture risk. Literature-reported studies performed some QUS measurements on proximal femur, but their clinical translation is mostly hindered by intrinsic factors (e.g., device bulkiness). An innovative ultrasound methodology has been recently introduced, which performs a combined analysis of B-mode images and corresponding "raw" radiofrequency signals acquired during an echographic scan of the target reference anatomical site, providing two novel parameters: Osteoporosis Score and Fragility Score, indicative of BMD level and bone strength, respectively. This article will provide a brief review of the available systems for osteoporosis diagnosis in clinical routine contexts, followed by a synthesis of the most promising research results on the latest ultrasound developments for early osteoporosis diagnosis and fracture prevention.

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Osteoporosis, frailty and fracture: implications for case finding and therapy

Cited by 143 publications

References 92 publications

AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells

AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells

Understanding Clinical Importance of Frailty and Designing a Frailty Assessment Tool in Acute Hospitals

New perspectives in echographic diagnosis of osteoporosis on hip and spine

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