Osteoporosis in anorexia nervosa: Prevention and treatment

Mehler, Philip S.

doi:10.1002/eat.10119

Cited by 45 publications

(29 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The integral (cortical and trabecular) bone density of the ultradistal radius was also markedly (D100 only moderately) affected in AN patients compared to young controls, thus confirming that AN patients significantly lose bone mass, a well-known fact reported by several studies over almost three decades [11] [12][13][14]. Interestingly, we found no significant difference in bone density of the cortical part of the ultradistal radius (Dcomp) and no significant difference in trabecular thickness (TbTh) between anorexic and healthy young women.…”

Section: Discussionsupporting

confidence: 71%

Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography

Milos

Häuselmann

Krieg

et al. 2014

Bone

View full text Add to dashboard Cite

This study intended to compare bone density and architecture in three groups of women: young women with anorexia nervosa (AN), an age-matched control group of young women, and healthy late postmenopausal women. Three-dimensional peripheral quantitative high resolution computed-tomography (HR-pQCT) at the ultradistal radius, a technology providing measures of cortical and trabecular bone density and microarchitecture, was performed in the three cohorts. Thirty-six women with AN aged 18-30years (mean duration of AN: 5.8years), 83 healthy late postmenopausal women aged 70-81 as well as 30 age-matched healthy young women were assessed. The overall cortical and trabecular bone density (D100), the absolute thickness of the cortical bone (CTh), and the absolute number of trabecules per area (TbN) were significantly lower in AN patients compared with healthy young women. The absolute number of trabecules per area (TbN) in AN and postmenopausal women was similar, but significantly lower than in healthy young women. The comparison between AN patients and post-menopausal women is of interest because the latter reach bone peak mass around the middle of the fertile age span whereas the former usually lose bone before reaching optimal bone density and structure. This study shows that bone mineral density and bone compacta thickness in AN are lower than those in controls but still higher than those in postmenopause. Bone compacta density in AN is similar as in controls. However, bone inner structure in AN is degraded to a similar extent as in postmenopause. This last finding is particularly troubling. This study showed that the degree of deterioration patterns of bone microarchitecture in AN is high, and needs to be deeply analyzed. Especially troubling is the highly significantly reduced number of trabecules in both young AN patients and in healthy late postmenopausal women, compared to healthy young controls. Keywords3D-pQCT; microarchitecture of bone; bone loss; anorexia nervosa; osteoporosis; postmenopausal women.

show abstract

Section: Discussionsupporting

confidence: 71%

Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography

Milos

Häuselmann

Krieg

et al. 2014

Bone

View full text Add to dashboard Cite

show abstract

“…[20][21][22][23][24] Low energy availability and decreased endogenous estrogen associated with amenorrhea can result in a decrease in bone mass, 25,26 because without estrogen, bone resorption exceeds bone formation. 27 As a consequence, the risk of stress fractures is increased in amenorrheic athletes. [28][29][30] Findings related to restoring bone mass have been mixed.…”

Section: Osteoporosismentioning

confidence: 99%

Practical use of the International Olympic Committee Medical Commission position stand on the female athlete triad: A case example

Sherman¹,

Thompson²

2006

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

“…Patients with AN have severe emaciation due to decreased food intake secondary to abnormal eating behavior and the pursuit of thinness. AN patients often suffer from physical complications, such as osteopenia and osteoporosis, and often incur pathologic fractures of the hip and/or spine (Brotman & Stern, 1885;Kaplan, Pertschuk, Fallo, & Haddad, 1986;Kiriike et al, 1992;Maugars et al, 1996;Mehler, 2003;Rigotti, Nussbaum, Herzog, & Neer, 1984). The cause of decreased bone mineral density (BMD) in patients with AN is controversial.…”

Section: Introductionmentioning

confidence: 99%

The effects of bone therapy on tibial bone loss in young women with anorexia nervosa

Nakahara

Nagai

Tanaka

et al. 2006

Int. J. Eat. Disord.

View full text Add to dashboard Cite

Osteoporosis in anorexia nervosa: Prevention and treatment

Cited by 45 publications

References 87 publications

Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography

Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography

Practical use of the International Olympic Committee Medical Commission position stand on the female athlete triad: A case example

The effects of bone therapy on tibial bone loss in young women with anorexia nervosa

Contact Info

Product

Resources

About