Osteoporosis in mineral and bone disorders of chronic kidney disease

Stompór, Tomasz; Zabłocki, Marek; Łesiów, Mirosław

doi:10.20452/pamw.1782

Cited by 12 publications

(14 citation statements)

References 48 publications

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“…Loss of bone mineral and trabecular integrity with age is of major concern for elderly patients with osteoporosis (1,2). Another associated feature of aging is the decline in glomerular filtration rate (GFR) (2).…”

Section: Discussionmentioning

confidence: 99%

“…Another associated feature of aging is the decline in glomerular filtration rate (GFR) (2). Whether the decline in GFR is normal to aging or signals underlying diseases that attend senescence is unknown (54-56).…”

Section: Discussionmentioning

confidence: 99%

“…Osteoporosis and a decline in estimated glomerular filtration rate (eGFR) occur in elderly patients and are major global health issues (1,2). Understanding the underlying disease process and etiology is important for developing drugs, early screening measures and preventive strategies.…”

Section: Introductionmentioning

confidence: 99%

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Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif

Zelenchuk

Hedge

Rowe

2015

Bone

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Context-Mice with null mutations in Matrix Extracellular Phosphoglycoprotein (MEPE) have increased bone mass, increased trabecular density and abnormal cancellous bone (MN-mice). These defects worsen with age and MEPE over expression induces opposite effects. Also, Genome Wide Association studies show MEPE plays a major role in bone mass. We hypothesized the conserved C-terminal MEPE ASARM-motif is chiefly responsible for regulating bone mass and trabecular structure.Design-To test our theory we over expressed C-terminal ASARM-peptide in MN-mice using the Col1α1 promoter (MNAt-mice). We then compared the bone and renal phenotypes of the MNAt-mouse with the MN-mouse and the X-linked hypophosphatemic rickets mouse (HYP). The HYP mouse over expresses ASARM-peptides and is defective for the PHEX gene.Results-The MN-mouse developed increased bone mass, bone strength and trabecular abnormalities that worsened markedly with age. Defects in bone formation were chiefly responsible with suppressed sclerostin and increased active β-catenin. Increased uric acid levels also suggested abnormalities in purine-metabolism and a reduced fractional excretion of uric acid signaled additional renal transport changes. The MN mouse developed a worsening hyperphosphatemia and reduced FGF23 with age. An increase in the fractional excretion of phosphate (FEP) despite the hyperphosphatemia confirms an imbalance in kidney-intestinal phosphate regulation. Also, the MN mice showed an increased creatinine clearance suggesting hyperfiltration. A reversal of the MN bone-renal phenotype changes occurred with the MNAt mice including the apparent hyperfiltration. The MNAt mice also developed localized hypomineralization, hypophosphatemia and increased FGF23.Conclusions-The C-terminal ASARM-motif plays a major role in regulating bone-mass and cancellous structure as mice age. In healthy mice, the processing and release of free ASARMAddress all correspondence to: Peter S N Rowe, Department of Internal Medicine, Division of Nephrology and Hypertension, The Kidney Institute, MS 3018, 3901 Rainbow Boulevard, Kansas City, KS 66160 USA, Tel: 913 588 0704 Fax: 913 588 9252 prowe@kumc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (Tables S1 and S2). In the text, supplemental figure and table numbers are prefixed with the letter S. HHS Public Access

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif

Zelenchuk

Hedge

Rowe

2015

Bone

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“…The epidemiology of fractures and management of other forms of secondary osteoporosis are discussed in relevant scientific papers. 26,27 The consensus on vitamin D supplementation reached in Warsaw in 2012 for the Central European countries 17 as well as American 28 and European 29,30 recommendations clearly point to the need of calcium and vitamin D supplementation (serum levels of 25[OH]D >30 ng/ml) as an indispensable standard both in prevention and pharmacotherapy of osteoporosis. Consistent with these standards, we make the following recommendations for Poland: 1) measurement of serum levels of 25(OH)D in patients and 2) adequate supplementation of calcium and vitamin D, particularly prior to inclusion of bisphosphonates.…”

Section: 20mentioning

confidence: 99%

Polish guidelines for the diagnosis and management of osteoporosis: a review of 2013 update

Głuszko¹,

Lorenc²,

Karczmarewicz³

et al. 2014

Polish Archives of Internal Medicine

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“…Opservaciona studija koja je sprovedena na dijaliziranim pacijentima u 11 zemalja i na 4 kontinenta ukazuje da je ukupan rizik od novog preloma kuka 9 puta veći u odnosu na opštu populaciju. 18 Preporuke za skrining.Kome uraditi osteodenzitometriju?…”

Section: Faktori Rizikaunclassified

Osteoporosis in primary health care: A silent epidemics

Vukosavljević¹,

Šimić²,

Vukosavljević³

et al. 2014

PONS

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1. Služba opšte medicine, Dom zdravlja, Jagodina 2. Služba opšte medicine, Dom zdravlja, Rekovac 3. Visoka medicinska škola strukovnih studija, Ćuprija 4. Služba za kućno i palijativno lečenje i negu, Dom zdravlja, Jagodina RECEIVED 29. 07.201407. . ACCEPTED 11.11.2014. SAŽETAKOsteoporoza je sistemska skeletna bolest koja se karakteriše niskom koštanom masom i pogoršanjem koštane mikoroarhitekture, što dovodi do povećane koštane fragilnosti i za posledicu ima povećani rizik od frakture. Procenjeno je da 22 miliona žena i 5,5 miliona muškaraca u Evropskoj uniji ima osteoporozu. Osteoporoza je asimptomatska bolest, simptomi su znak uznapredovalog oboljenja i posledica nastalih fraktura. Dijagnoza osteoporoze se postavlja na osnovu merenja mineralne koštane gustine (BMD) metodom dvostruke apsorpcije X zraka (DEXA), na lumbalnoj kičmi i na proksimalnom femuru. BMD se opisuje kao T skor i Z skor. T skor predstavlja odstupanje BMD pacijenta od srednje vrednosti BMD za odgovarajući pol i konstituciju, osobe 20-30 godina starosti,, izraženo u standardnim devijacijama (SD) . Osteoporoza postoji kada je BMD 2,5 SD ili više, ispod prosečne vrednosti za mlade zdrave žene (T skor < -2,5 SD). .Skrining vrši kod žena starijih od 65. godina i muškaraca starijih od 70. godina, zatim kod starijih od 50. godina sa frakturom na minimalnu traumu, kao i kod odabranih postmenopauzalnih žena i muškaraca sa faktorima rizika za nastanak preloma. Osteoporoza se može prevenirati i lečiti. Prevencija obuhvata sprečavanje padova, adekvatan dnevni unos kalcijuma i vitamin D. U tretmanu osteoporoze koriste se sledeće kategorije medikamenata: antiresorptivni lekovi koji usporavaju gubitak kosti-bisfosfonati, kalcitonin, denosumab, estrogen i selektivni modulatori estrogenskih receptora (SREM), anabolički lekovi koji povećavaju formiranje kosti-teriparatide kao i lekovi koji istovremeno imaju i antiresorptivni i anabolički efekat-stroncijum ranelat. . Neophodno je vršiti procenu terapije, merenjem BMD-a prvi put nakon 24 meseca Ključne reči: osteoporoza, mineralna koštana gustina, T skor, faktori rizika, prevencija, lečenje ABSTRACTOsteoporosis is a systemic skeletal disease characterized by low bone mass and deterioration of bone microarchitecture, which leads to bone fragility and resulting in an increased risk of fractures. It is estimated that 22 million women and 5.5 million men in the European Union have osteoporosis. Osteoporosis is asymptomatic disease, the symptoms are a sign of advanced disease and the consequences of fractures. The diagnosis of osteoporosis is based on the measurement of bone mineral density (BMD) using dual X-ray absorption (DEXA) at the lumbar spine and proximal femur. BMD is described as a T score and the Z score. T score represents the deviation of BMD from the mean BMD of the appropriate for gender and constitution, in persons 20-30 years of age, expressed in standard deviations (SD). Osteoporosis occurs when the BMD is -2.5 SD or more below the average value for young healthy women (T score <-2.5 SD). Skrining ...

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Osteoporosis in mineral and bone disorders of chronic kidney disease

Cited by 12 publications

References 48 publications

Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif

Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif

Polish guidelines for the diagnosis and management of osteoporosis: a review of 2013 update

Osteoporosis in primary health care: A silent epidemics

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