Osteoporosis in Thyrotoxicosis

Ikkos, D; Katsichtis, P; Ntalles, K.; Velentzas, Christos

doi:10.1016/s0140-6736(71)91323-7

Cited by 14 publications

(2 citation statements)

References 4 publications

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“…, 1985) leading even to compression fractures of the spine in some patients (Frazer et a/.,197 I). According to some observations osteoporosis could be revealed only in older patients (Ikkos et al, 1971;Smith et al, 1973), while others found a decrease of BMC in both young and old manifest hyperthyroid subjects (Toh et al, 1985). Our present study confirms previous findings.…”

Section: Discussionsupporting

confidence: 91%

Bone mineral density in patients with endogenous subclinical hyperthyroidism: Is this thyroid status a risk factor for osteoporosis?

Földes

Tarján

Szathmári

et al. 1993

Clinical Endocrinology

153

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This study indicates that the bone mineral density of the lumbar spine, femoral neck and the midshaft of the radius are not significantly decreased in premenopausal patients with endogenous subclinical hyperthyroidism resulting from a solitary autonomously functioning thyroid nodule. Conversely, findings hint at the possibility that long-lasting endogenous subclinical hyperthyroidism may be a contributing factor to the development of osteoporosis in some post-menopausal women, mostly at sites where cortical bone preponderates.

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Section: Discussionsupporting

confidence: 91%

Bone mineral density in patients with endogenous subclinical hyperthyroidism: Is this thyroid status a risk factor for osteoporosis?

Földes

Tarján

Szathmári

et al. 1993

Clinical Endocrinology

153

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“…The incidence of bone changes has been dependent on the method of investig¬ ation. Striation of the cortex of the metacarpal bone cortex was found on x-ray examination in 75fl/o of patients with hyperthyroidism (Meema 8c Meema 1972) whereas a decreased cortical width was found in only a few patients (Ikkos et al 1971; Koutras et al 1973; Meema 8c Meema 1972). By osteodensitometric methods a low mineral content was found in about 25 % of patients (Fraser et al 1971; Meema 8c Meema 1972).…”

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confidence: 99%

The Degree of Bone Mineralization in Hyperthyroidism Estimated From the Phosphorus to Hydroxyproline Ratio in Bone

Tougaard

1976

Acta Endocrinologica

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The proportion between mineral and collagen in bone tissue, "the degree of mineralization", can be evaluated from the phosphorus to hydroxyproline ratio (P/Hypro ratio), determined in bone biopsies. The ratio was measured in 27 unselected hyperthyroid patients. No significant correlation was found between the P/Hypro ratio and the age of the patient, the duration of the disease or the value of serum thyroxine. The mean value of the P/Hypro ratio for the group studied was not significantly different from the normal mean. The results of the study indicate a normal degree of mineralization in the bone of patients with hyperthyroidism. Though rather asymptomatic in most patients, bone changes have been de¬ scribed for many years in the hyperthyroid state (von Recklinghausen 1891). The incidence of bone changes has been dependent on the method of investig¬ ation. Striation of the cortex of the metacarpal bone cortex was found on x-ray examination in 75fl/o of patients with hyperthyroidism (Meema 8c Meema 1972) whereas a decreased cortical width was found in only a few patients (Ikkos et al. 1971; Koutras et al. 1973; Meema 8c Meema 1972). By osteodensitometric methods a low mineral content was found in about 25 % of patients (Fraser et al. 1971; Meema 8c Meema 1972). Bone histology has shown divergent results in hyperthyroidism. Sometimes increased osteoid surfaces as in osteomalacia

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