Osteoporosis influences the early period of fracture healing in a rat osteoporotic model

Namkung-Matthai, H; Appleyard, Richard; Jansen, J.; Lin, Jianhua; Maastricht, S; Swain, Michael V.; Mason, Rebecca S.; Murrell, George A. C.; Diwan, Ashish D.; Diamond, Terrence

doi:10.1016/s8756-3282(00)00414-2

Cited by 325 publications

(221 citation statements)

References 29 publications

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“…A similar response was observed in female rats (Komrakova et al 2010), supporting the statement that stimulation of bone healing by PTH is more effective in healthy organisms with unaltered levels of gonadal hormones than in testosterone/ estrogen-deficient rats. Although fracture healing is supposed to be impaired in osteoporotic organisms (Namkung-Matthai et al 2001, bone bridging in Orx rats occurred earlier than in sham rats (days 27 vs 32). Decreased callus area in Orx rats may be a consequence of diminished bone formation rate and periosteal apposition rate reported in rats after orchiectomy (Turner et al 1989).…”

Section: Discussionmentioning

confidence: 92%

Influence of intermittent administration of parathyroid hormone on muscle tissue and bone healing in orchiectomized rats or controls

Komrakova¹,

Krischek²,

Wicke³

et al. 2011

Journal of Endocrinology

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Influence of human parathyroid hormone (hPTH 1-34) on muscle and bone healing was studied in either orchiectomized (Orx at 8 months of age) or sham-operated male rats. Eleven-month-old Sprague-Dawley rats underwent bilateral transverse metaphyseal osteotomy of tibia and were divided into four groups (nZ12): 1) sham-vehicle, 2) sham group-PTH everyday, 3) Orx-vehicle, 4) Orx-PTH everyday, and 5) Orx-PTH every other day. PTH dosage was 40 mg/kg body weight. After 5 weeks, fiber cross-sectional area, capillary density, and enzyme activity (lactate dehydrogenase, citrate synthase, and complex I) were measured in soleus (MS), gastrocnemius (MG), and longissimus (ML) muscles; tibiae were analyzed by computed tomographical, histological, and gene expression analyses. The effect of PTH in all rats was increased serum osteocalcin, cortical and callus densities and callus area. In sham rats capillary density was increased in limb muscles (MS: 1 . 3-1 . 7, MG: 1 . 2-1 . 4 capillaries/fiber), and rate of osseous bridging of osteotomy was enhanced (67-100%). In Orx rats serum creatine kinase was decreased (6670-2847 U/l), and bone genes (Igf-1, osteoprotegerin, and receptor activator of nuclear factor kB ligand) were up-regulated. Cross-sectional area, enzyme activity, food intake, weight of body, visceral organs, adipose tissue, MG, and MS were not affected by PTH. PTH had a favorable effect on muscle capillary density and improved bone healing being more effective in sham rats and having no adverse systemic effect. The effect was less if PTH was applied every other day. The findings may show up trends for therapeutic treatment of male patients.

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Section: Discussionmentioning

confidence: 92%

Influence of intermittent administration of parathyroid hormone on muscle tissue and bone healing in orchiectomized rats or controls

Komrakova¹,

Krischek²,

Wicke³

et al. 2011

Journal of Endocrinology

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“…16,17 Although these mechanisms of osteoclast action for bone resorption are well known, the bone remodelling process is not yet completely understood when osteoporosis is present. 18 Pathological fractures are the natural consequence of osteoporosis and, for this reason, much attention has been given to fracture prevention through pharmacological and physical therapies. However, less attention has been directed at the study of orthopaedic biomaterials behaviour when implanted in Biomaterials that enhance the osteogenic function while decreasing the osteoclasts-mediated resorption, would be of great interest to fabricate implants specially tailored for osteoporotic patients.…”

Section: Introductionmentioning

confidence: 99%

Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity

Matesanz¹,

Linares

Lilue³

et al. 2014

J. Mater. Chem. B

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In the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory and reparative macrophage populations was also studied. NanoSiHA disks delayed the osteoclast differentiation and decreased the resorptive activity of these cells on their surface, as compared to nano-HA samples, without affecting cell viability. Powdered nano-SiHA also induced an increase of the reparative macrophage population. These results along with the beneficial effects on osteoblasts previously observed with powdered nano-SiHA suggest the potential of this biomaterial for modulating the fundamental processes of bone formation and turnover, preventing bone resorption and enhancing bone formation at implantation sites in treatment of osteoporotic bone and in bone repair and regeneration.

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“…Due to excessive bone resorption and deficient bone formation, osteoporotic bodies with fracture are usually subject to depressed callus quality and prolonged healing time, even nonunion [1][2][3][4]. Consequently, there has been interest in treatments that could enhance callus formation and shorten healing time on osteoporotic fracture.…”

Section: Introductionmentioning

confidence: 99%

The effects of combined human parathyroid hormone (1-34) and zoledronic acid treatment on fracture healing in osteoporotic rats

Zhou

et al. 2011

Osteoporos Int

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Osteoporosis influences the early period of fracture healing in a rat osteoporotic model

Cited by 325 publications

References 29 publications

Influence of intermittent administration of parathyroid hormone on muscle tissue and bone healing in orchiectomized rats or controls

Influence of intermittent administration of parathyroid hormone on muscle tissue and bone healing in orchiectomized rats or controls

Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity

The effects of combined human parathyroid hormone (1-34) and zoledronic acid treatment on fracture healing in osteoporotic rats

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