Osteoporosis is inversely associated with arterial stiffness in the elderly: An investigation using the Osteoporosis Self‐assessment Tool for Asians index in an elderly Chinese cohort

Abstract

Although the association of arterial stiffness and osteoporosis has been reported, the relation of arterial stiffness with risk of osteoporosis and bone fracture is not established. The authors investigated the correlation between arterial stiffness (brachial‐ankle pulse wave velocity [baPWV]), including a cutoff value, and risk of osteoporosis as assessed by the Osteoporosis Self‐assessment Tool for Asia (OSTA) index in 129 elderly Chinese community‐dwelling individuals (age 83.2 ± 12.8 years, 63 females). OSTA was negatively correlated with baPWV (r = −0.326, P = 0.023) after adjusting for confounding factors such as gender, body mass index, low‐density lipoprotein, triglycerides, estimated glomerular filtration rate, absence or presence of diabetes, absence or presence of hypertension, and uric acid. baPWV was an independent factor for changes in OSTA (β = −0.001, P = 0.002). ROC curve analysis confirmed association between baPWV and OSTA index (AUC = 0.742 [CI: 0.660, 0.824]; P < 0.001) with a baPWV cutoff value of 1676 cm/s (sensitivity, 80.7%; specificity, 60%) for prediction of high OSTA index. The study showed a significant correlation between OSTA index and baPWV, suggesting a potential predictive value of baPWV in elderly patient at high risk of osteoporosis.

Brachial-Ankle Pulse Wave Velocity is Associated With the Risk of Osteoporosis: A Cross-Sectional Evidence From A Chinese Community-Based Cohort

“…Our ndings have proven the association in a large Chinese Community-based Cohort involving 1,407 individuals, the AUC was 0.722 in ROC curve analysis for evaluating baPWV as a predictor of high risk of osteoporosis and fracture (OSTA ≤ − 4), close to the AUC (0.742) reported in the above mentioned study (35). However, we reported a low sensitivity value of 51.8% for the optimal cutoff point of baPWV value in predicting the presence of high risk of osteoporosis and fracture.…”

“…It is important to obtain a simple and effective way to predict osteoporosis and cardiovascular disease risk, considering the huge aging population of People's Republic of China. As far as we know, the rst study to report the relationship between OSTA and baPWV in Chinese population was published in 2019, involving 129 elderly individuals and suggests the OSTA index was negatively correlated with baPWV in linear regression analysis and baPWV as a valuable predictive factor for potential osteoporotic risk (35).…”

Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort

“…It is important to obtain a simple and effective way to predict osteoporosis and cardiovascular disease risk, considering the huge aging population of the People's Republic of China. As far as we know, the first study to report the relationship between OSTA and baPWV in Chinese population was published in 2019, involving 129 elderly individuals and suggests the OSTA index was negatively correlated with baPWV in linear regression analysis and baPWV as a valuable predictive factor for potential osteoporotic risk [46]. Our findings have proven the association in a large Chinese communitybased cohort involving 1407 individuals; the AUC was 0.722 in ROC curve analysis for evaluating baPWV as a predictor of high risk of osteoporosis and fracture (OSTA ≤ − 4), close to the AUC (0.742) reported in the abovementioned study [46].…”