Osteoporosis: Pathogenesis, New Therapies and Surgical Implications

Labovitz, Jonathan M.; Revill, Kate

doi:10.1016/j.cpm.2006.12.002

Clinics in Podiatric Medicine and Surgery

2007

DOI: 10.1016/j.cpm.2006.12.002

|View full text |Cite

Osteoporosis: Pathogenesis, New Therapies and Surgical Implications

Jonathan M. Labovitz

Kate Revill

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2008

2017

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 7 publications

(4 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteoporosis affects more than 10 million people in the USA and will affect over 14 million over the age of 50 by 2020 9 . Hip fractures are the most devastating type of fracture.…”

mentioning

confidence: 99%

“…Hip fractures are the most devastating type of fracture. A 2005 estimate suggested that there are approximately 1.5 million hip fractures per year 9 . By 2050, there will be almost 6.3 million.…”

mentioning

confidence: 99%

“…8 Osteoporosis affects more than 10 million people in the USA and will affect over 14 million over the age of 50 by 2020. 9 Hip fractures are the most devastating type of fracture. A 2005 estimate suggested that there are approximately 1.5 million hip fractures per year.…”

mentioning

confidence: 99%

“…A 2005 estimate suggested that there are approximately 1.5 million hip fractures per year. 9 By 2050, there will be almost 6.3 million. In the United States, almost all hip fracture patients are hospitalized, representing almost half of all hospitalizations for outpatient fractures.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Osteoporosis in adults with cerebral palsy

Sheridan

2009

Develop Med Child Neuro

View full text Add to dashboard Cite

Life expectancy for the 400 000 adults with cerebral palsy (CP) in the USA is increasing. Although there is a perception of increased fractured rate in the adult with CP, it has not been well studied. Low bone mineral density is found in more than 50% of adults with a variety of disabilities, including CP. Dual‐energy X‐ray absorptiometry scanning is commonly used to assess bone mineral density, but is limited by positioning and other artifacts in adults with CP. Novel scanning regions of interest, such as the distal femur, are not yet standardized in adults. Nutritional assessment and physical activity, the basis of most fracture prevention programs, are difficult to do in the adult with CP. A better understanding of the ‘muscle‐bone unit’ physiology and its exploitation may lead to better treatment modifications. Clinical research trials with bisphosphonates (e.g. pamidronate), estrogen, selective estrogen receptor modulators, parathyroid hormone analogs, and growth hormone need to be targeted to the adult with CP. Longitudinal studies of fracture risk factors, genetic research in bone and neuromuscular biology, and the development of treatment surrogates for physical activity are additional areas of needed expertise. This could be facilitated by an adult CP registry and the centralization of clinical research efforts.

show abstract

“…Osteoporosis affects more than 10 million people in the USA and will affect over 14 million over the age of 50 by 2020 9 . Hip fractures are the most devastating type of fracture.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Osteoporosis in adults with cerebral palsy

Sheridan

2009

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

Healing in the New Millennium: Bone Stimulators

Cook¹,

Summers²,

Cook³

2015

Clinics in Podiatric Medicine and Surgery

View full text Add to dashboard Cite

Tissue engineering of bone and cartilage

Ohba¹,

Yano²,

Chung³

2009

IBMS BoneKEy

View full text Add to dashboard Cite

In vertebrates, the skeleton has pivotal roles in mobility, locomotion, calcium homeostasis, hematopoiesis and protection. Therefore, irreversible skeletal defects often incur considerable morbidity. Tissue engineering has drawn attention as a promising strategy for the treatment of irreversible tissue defects. There are three pillars important for tissue engineering: cell sources, signaling factors, and scaffolds. Since the late 1990s, substantial progress has been made in tissue engineering of bone and cartilage along with advances in stem cell biology, bone and cartilage biology, and materials science. In particular, autologous cell implantation combined with biodegradable scaffolds have been extensively researched. This Perspective aims to review recent advances and major obstacles currently faced by the field of tissue engineering of bone and cartilage. It includes discussion of each pillar of tissue engineering, with a focus on several preclinical and clinical studies that are milestones in this field, and suggests future perspectives and directions.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Osteoporosis: Pathogenesis, New Therapies and Surgical Implications

Cited by 7 publications

References 77 publications

Osteoporosis in adults with cerebral palsy

Osteoporosis in adults with cerebral palsy

Healing in the New Millennium: Bone Stimulators

Tissue engineering of bone and cartilage

Contact Info

Product

Resources

About