Objective. To analyse literature data reflecting the issue of prevention of calcium and vitamin D deficiency in osteoporosis. Material and methods. Analysis of 47 Russian and foreign publications on prevention of calcium and vitamin D deficiency in osteoporosis was carried out. Results and discussion. The role of vitamin D in maintenance of calcium homeostasis and bone metabolism has been shown. Lack of vitamin D is associated with the development of osteomalacia and osteoporosis in adults and rickets in children. It was noted that hypovitaminosis D was recognised as a worldwide pandemic. It was acknowledged that there was a need to develop dietary recommendations, supplementary intake of vitamin D to prevent, among other things, bone diseases in most countries of the world. The results of the study of the Russian drugs Osteomed, Osteomed Forte, Osteo-Vit D3 (Parapharm, Russia) were presented. Conclusions. Thus, combined preparations of Ca and vitamin D were of great importance for prevention and complex treatment of osteoporosis, for the compensation of calcium deficiency in adolescence, elderly, during pregnancy, lactation and after menopause. Combined calcium and vitamin D supplementation was more effective than monotherapy in slowing bone loss, reducing the risk of fractures, strengthening the skeletal musculature and reducing the probability of falls, disability and death, but promotes calcification of soft tissues and blood vessels. At the same time, the only osteoprotectors without the risk of calcification of blood vessels and soft tissue, as well as the development of atherosclerosis, to date recognized by the Russian line of drugs "Osteomed. The safety of this group of dietary supplements, including their use in the treatment of bone pathologies in children and adolescents, is ensured by the presence of a unique HDBA organic complex. This component, by correcting the hormonal status and maintaining an optimal level of androgens within the age norm, has an anabolic effect, stimulating the birth of new bone cells. It is activation of reparative processes at the cellular level that enables to realize the effect of targeted delivery of calcium into bone tissue.
