Osteoporosis Therapy: Bone Modeling during Growth and Aging

Sugiyama, Toshihiro; Oda, Hiromi

doi:10.3389/fendo.2017.00046

Cited by 23 publications

(14 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(1) Higher circulating levels of sclerostin has also been suggested to play a role in the relationship between CKD and greater bone marrow adiposity. (10) Of note, several lines of evidence have shown that physical inactivity can result in higher circulating levels of sclerostin (11) and greater bone marrow adiposity, (12) which reasonably supports the above-mentioned theory that poor vitamin K status reflects physical inactivity and can be regarded as an indirect indicator of hip fragility in CKD.…”

Section: To the Editorsupporting

confidence: 54%

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility

Sugiyama

2019

Journal of Bone and Mineral Research

Self Cite

View full text Add to dashboard Cite

Section: To the Editorsupporting

confidence: 54%

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility

Sugiyama

2019

Journal of Bone and Mineral Research

Self Cite

View full text Add to dashboard Cite

“…Fragility fracture risk, associated with OP, can be decreased by following an exercise programme, as exercise increases bone density and reduces inflammatory markers [31]. However, the incidence of OP is usually highest in elderly females who are most unlikely to perform the dynamic exercises needed for bone modelling/remodelling [32]. This highlights the challenge of preventing OP and OP-related fractures in elderly females that cannot perform ballistic exercise.…”

Section: Healthy Ageing and Physical Exercisementioning

confidence: 99%

Strategies for optimising musculoskeletal health in the 21st century

Lewis

Álvarez

Rayman

et al. 2019

BMC Musculoskelet Disord

143

View full text Add to dashboard Cite

We live in a world with an ever-increasing ageing population. Studying healthy ageing and reducing the socioeconomic impact of age-related diseases is a key research priority for the industrialised and developing countries, along with a better mechanistic understanding of the physiology and pathophysiology of ageing that occurs in a number of age-related musculoskeletal disorders. Arthritis and musculoskeletal disorders constitute a major cause of disability and morbidity globally and result in enormous costs for our health and social-care systems. By gaining a better understanding of healthy musculoskeletal ageing and the risk factors associated with premature ageing and senescence, we can provide better care and develop new and better-targeted therapies for common musculoskeletal disorders. This review is the outcome of a two-day multidisciplinary, international workshop sponsored by the Institute of Advanced Studies entitled "Musculoskeletal Health in the 21st Century" and held at the University of Surrey from 30th June-1st July 2015. The aim of this narrative review is to summarise current knowledge of musculoskeletal health, ageing and disease and highlight strategies for prevention and reducing the impact of common musculoskeletal diseases.

show abstract

“…The nature of microdamage accumulations under fatigue loading and its location in the bone matrix plays a role in determining the age-related fragility of cortical bone [ 6 ]. Particular emphasis is placed on the role of estrogen in the signaling pathway related to the biological remodeling process through resorption/regeneration contributing to bone strength [ 3 , 16 , 2 3 - 25 ]. Therefore, the OVX rat is a widely used preclinical model approved by the Food and Drug Administration that emulates the important clinical feature of the postmenopausal human skeleton [ 12 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional microstructures of the intracortical canals in the animal model of osteoporosis

et al. 2020

View full text Add to dashboard Cite

Osteoporosis is a major disease in aged women, increasing the risk for fractures accompanied by changes in the microarchitecture. The aim of this study was to investigate the three-dimensional (3D) histomorphology of femur diaphysis in the animal model for postmenopausal osteoporosis. The cortical bone of femur diaphysis of the rat was serially sectioned at a thickness of 5 mm and evaluated age-associated changes of the intracortical (osteonal) canal networks three-dimensionally. Cortical microstructures of 10-month old rats were not affected by ovariectomy. Intracortical canal networks were radial toward endosteal aspect and frequently interconnected across the neighboring canals with short arciform and irregular canals reminiscent for resorption spaces in ovarectomized 16-month old rats, contrary to intact canals in 16-month old control rat. Increased proportion of the periosteal circumference lamella and deformed endosteal regions with rare cortical canals hampered reconstructive histomorphology in ovarectomized rats of 26 month age. We have shown that 3D reconstruction of rat femur of the aged model over 16-month old is suitable methods that evaluate and microstructural change of the intracortical canals and cortical bone porosity by estrogen depletion.

show abstract

Osteoporosis Therapy: Bone Modeling during Growth and Aging

Cited by 23 publications

References 60 publications

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility

Strategies for optimising musculoskeletal health in the 21st century

Three-dimensional microstructures of the intracortical canals in the animal model of osteoporosis

Contact Info

Product

Resources

About