Osteoporosis treatment by mesenchymal stromal/stem cells and their exosomes: Emphasis on signaling pathways and mechanisms

Rudiansyah, Mohammad; El-Sehrawy, Amr A; Ahmad, Irfan; Terefe, Ermias Mergia; Abdelbasset, Walid Kamal; Bokov, Dmitry Olegovich; Salazar, Alelí; Rizaev, Jasur; Muthanna, Fares Mohammed Saeed; Shalaby, Mohammed Nader

doi:10.1016/j.lfs.2022.120717

Cited by 12 publications

(8 citation statements)

References 197 publications

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“…Signaling pathways are integral in the action of exosomes secreted by MSCs as vehicles for drug delivery to treat osteoporosis [ 85 ]. Researchers have discovered that BMSC-Exos activates the Wnt/β-catenin pathway to promote osteogenic differentiation, due to its being enriched in miR-196a, and delivers it to HFOB1.19 cells to inhibit Dickkopf-1 (Dkk1), a negative regulator of the Wnt/β-catenin pathway [ 86 ].…”

Section: Role Of Exosomes As Drug Delivery Systems In Bone-related Di...mentioning

confidence: 99%

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Huang

Wang

et al. 2023

Pharmaceutics

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Bone-related diseases are major problems and heavy burdens faced by modern society. Current clinical approaches for the treatment of these pathological conditions often lead to complications and have limited therapeutic efficacy. In this context, the development of nanotherapeutic platforms, such as extracellular vesicles, can improve the relevant therapeutic effects. In particular, exosomes are nano-sized, lipid bilayer extracellular vesicles secreted by many cells in mammals. Due to their innate capacity to transport materials—including proteins, lipids, and genes—among cells, as well as their innate attraction to target cells, they are considered to be a crucial medium for cell communication and are involved in a number of biological processes. Exosomes have been used as drug delivery vehicles in recent bone tissue engineering studies, in order to regulate bone homeostasis. However, the precise workings of the exosome regulatory network in maintaining bone homeostasis and its potential for treating bone injury remain unclear. To provide a fresh perspective for the study of exosomes in drug delivery and bone-related diseases, in this paper, we review recent studies on the roles of exosomes for drug delivery in bone homeostasis and bone-related diseases, as well as the composition and characteristics of exosomes and their regulatory roles in bone homeostasis and bone-related diseases, aiming to provide new ideas for the therapeutic application of exosomes in the treatment of bone-related diseases.

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Section: Role Of Exosomes As Drug Delivery Systems In Bone-related Di...mentioning

confidence: 99%

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Huang

Wang

et al. 2023

Pharmaceutics

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“…MSCs-derived exosomes can promote the formation of new bone with vasculature, biomechanics, and histology[ 20 ]. MSCs-derived exosomes regulate bone metabolism and treat OP through signaling pathways, such as stimulating osteoblast differentiation from bone marrow stem cells, promoting osteoblast proliferation, inducing angiogenesis, and immunomodulation[ 21 ]. During treatment, MSCs-derived exosomes achieve the purpose of bone regeneration and treatment of OP by carrying and transporting proteins, miRNAs, and artificial synthetic drugs[ 22 - 24 ].…”

Section: Mscs-derived Exosomes In the Treatment Of Opmentioning

confidence: 99%

Mesenchymal stem/stromal cells-derived exosomes for osteoporosis treatment

Huo¹,

Yang²,

Zhang³

et al. 2023

World J Stem Cells

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Osteoporosis is a systemic bone disease, which leads to decreased bone mass and an increased risk of fragility fractures. Currently, there are many anti-resorption drugs and osteosynthesis drugs, which are effective in the treatment of osteoporosis, but their usage is limited due to their contraindications and side effects. In regenerative medicine, the unique repair ability of mesenchymal stem cells (MSCs) has been favored by researchers. The exosomes secreted by MSCs have signal transduction and molecular delivery mechanisms, which may have therapeutic effects. In this review, we describe the regulatory effects of MSCs-derived exosomes on osteoclasts, osteoblasts, and bone immunity. We aim to summarize the preclinical studies of exosome therapy in osteoporosis. Furthermore, we speculate that exosome therapy can be a future direction to improve bone health.

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“…However, these treatments have certain drawbacks, including insufficient graft quantity, donor site morbidity, and contamination. Currently, bone tissue engineering (BTE) is considered an alternative to bone grafting in replacing damaged bones using biomaterials [ 109 - 111 ] . Literature reports have revealed that about 2.2 million patients worldwide undergo bone grafting each year [ 112 ] .…”

Section: Combining Cfns and 3d Bioprintingmentioning

confidence: 99%

State-of-the-art techniques for promoting tissue regeneration: Combination of three-dimensional bioprinting and carbon nanomaterials

Raja¹,

Kang²,

Hong³

et al. 2022

IJB

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Biofabrication approaches, such as three-dimensional (3D) bioprinting of hydrogels, have recently garnered increasing attention, especially in the construction of 3D structures that mimic the complexity of tissues and organs with the capacity for cytocompatibility and post-printing cellular development. However, some printed gels show poor stability and maintain less shape fidelity if parameters such as polymer nature, viscosity, shear-thinning behavior, and crosslinking are affected. Therefore, researchers have incorporated various nanomaterials as bioactive fillers into polymeric hydrogels to address these limitations. Carbon-family nanomaterials (CFNs), hydroxyapatites, nanosilicates, and strontium carbonates have been incorporated into printed gels for application in various biomedical fields. In this review, following the compilation of research publications on CFNs-containing printable gels in various tissue engineering applications, we discuss the types of bioprinters, the prerequisites of bioink and biomaterial ink, as well as the progress and challenges of CFNs-containing printable gels in this field.

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Osteoporosis treatment by mesenchymal stromal/stem cells and their exosomes: Emphasis on signaling pathways and mechanisms

Cited by 12 publications

References 197 publications

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Mesenchymal stem/stromal cells-derived exosomes for osteoporosis treatment

State-of-the-art techniques for promoting tissue regeneration: Combination of three-dimensional bioprinting and carbon nanomaterials

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