Osteoporotic hip fracture mortality and associated factors in Hawai’i

Hori, Kaitlin; Siu, Andrea M; Nguyen, Edward T.; Andrews, Samantha; Choi, So Yung; Ahn, Hyeong Jun; Nakasone, Cass K.; Lim, Sian Yik

doi:10.1007/s11657-020-00847-9

Cited by 12 publications

(5 citation statements)

References 39 publications

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“…A previous study showed that an increasing BMI tended to reduce the risk of hip fractures and the prevalence of vertebral deformity [13]. When the fracture risk was adjusted for the BMD, the BMI appeared to be a predictor only for hip fracture [14]. This might be attributed to the fact that cortical bone rather than trabecular bone is preferentially affected by obesity [15].…”

Section: Discussionmentioning

confidence: 94%

The Influence of Body Fat Content and Distribution on Bone Mass in Healthy Chinese Adults

Chen

Liu

Wang

et al. 2022

Preprint

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Introduction: Many previous studies have reported a close relationship between body mass index (BMI) and bone mineral density (BMD). However, the effects of fat on bone health remain controversial, particularly for fat tissue distribution.Methods: This study enrolled 18,263 participants who had undergone health examinations. Body composition and BMD were measured using dual-energy X-ray absorptiometry. The relationships of BMI and regional fat percentage with BMD were detected by multiple linear regression and generalized additive models. The risk of low BMD was calculated using logistic regression.Results: There was a negative relationship between the regional fat percentage and FN BMD or LS BMD in both genders (P<0.05). In females, this relationship was bidirectional. Multiple logistic regression analyses showed that the risk for low BMD linearly increased across increasing regional fat percentage quartile categories. In females, the ORs for low LS BMD were 3.095 (95% CI, 2.618-3.658) for hip fat percentage and 1.532 (95% CI, 1.271-1.848) for waist fat percentage. In males, the ORs for low FN BMD were 2.211 (95% CI, 1.831-2.670) for waist fat percentage and 1.998 (95% CI, 1.694-2.355) for hip fat percentage.Conclusions: Overall, the body fat content was a negative predictor of the BMD, and this effect was gender- and location-dependent. In males, waist fat has a greater effect on the FN BMD, whereas in females, hip fat exerts a more negative influence on the LS BMD, which implies a cross-influence between regional fat content and bone mineral density in males and females.

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Section: Discussionmentioning

confidence: 94%

The Influence of Body Fat Content and Distribution on Bone Mass in Healthy Chinese Adults

Chen

Liu

Wang

et al. 2022

Preprint

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“…A retrospective chart review was conducted of patients diagnosed and treated for NTM SSTI at four medical centers within the Hawaiʻi Pacific Health (HPH) system from 2010 to 2021. Hawaiʻi Pacific Health is Hawaiʻi’s largest health care provider with four medical centers and over 70 clinics across the state [ 9 ]. The study was reviewed and determined to be exempt from Institutional Review Board approval by the HPH Research Institute.…”

Section: Methodsmentioning

confidence: 99%

Nontuberculous mycobacterial skin and soft tissue infection in Hawaiʻi

2022

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Background Hawaiʻi has the highest nontuberculous mycobacterial (NTM) lung infection prevalence in the United States. Limited data regarding skin and soft tissue infections (SSTI) due to NTM in Hawaiʻi exists. This study describes patient demographics, clinical courses of infection, treatment patterns, and clinical outcomes of NTM SSTIs in Hawaiʻi. Methods A retrospective chart review (n = 50) of patients diagnosed and treated at Hawaiʻi Pacific Health facilities for NTM SSTIs between January 2010 and July 2021 was conducted. Patient demographics, clinical course, and treatment data were collected from electronic medical records. Results Half of the patient population consisted of females, and the average age of patients during infection was 49 years (SD = 25.6). The majority of cases (80%) were caused by rapidly growing mycobacteria (RGM), most commonly Mycobacterium abscessus. NTM SSTI by race were Asian (48%), White (28%), and Native Hawaiian and Other Pacific Islanders (16%). Almost all Asian patients with NTM SSTI were Filipino or Japanese. Diagnosis was frequently delayed. The average time to diagnosis was 116 days. Most patients achieved complete resolution (72%) following a prolonged course of antimicrobial treatment (mean = 196 days) with surgical debridement. Conclusion Increased awareness among physicians and the community of non-mycobacterial skin infections is essential in Hawaiʻi due to the high prevalence of NTM and the high percentage of predisposed populations. Increased awareness of NTM could reduce delayed diagnosis and improve patient care. Further studies are required to inform optimal treatment and diagnostic strategies, improve patient outcomes, and aid public health surveillance efforts.

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“…A study from China reported that the incidence of hip fractures over 60 years of age increased from 2007 (63.57%) to 2018 (74.05%) [ 1 ]. The high mortality rate associated with hip fractures has been well documented in studies and surveys in the United States and Europe [ 3 – 5 ]. It was reported that the one-year mortality was 30% rate after hip surgery [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The association between admission serum albumin and preoperative deep venous thrombosis in geriatrics hip fracture: a retrospective study of 1819 patients with age ≥ 65 years

Wu,

Zhang,

Zhang

et al. 2023

BMC Musculoskelet Disord

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Objective This study evaluated the association between serum albumin levels and preoperative deep vein thrombosis (DVT) in geriatric hip fractures. Methods Older adult patients with hip fractures were screened between January 2015 and September 2019. The demographic and clinical characteristics of the patients were collected. Multivariate binary logistic regression and generalized additive model were used to identify the linear and nonlinear association between albumin levels and preoperative DVT. Analyses were performed using EmpowerStats and the R software. Results A total of 1819 patients were included in this study. The average age was 79.37 ± 6.88 years. There were 550 males and 1269 females. The preoperative albumin was 38.19 ± 4.07 g/L. There were 580 (31.89%) preoperative DVTs. Multivariate binary logistic regression showed that albumin level was associated with preoperative DVT (odds ratio [OR] = 0.94, 95% confidence interval [CI]: 0.91–0.97, P = 0.0002) after adjusting for confounding factors. The fully adjusted model showed a DVT risk decrease of 6% when albumin concentration increased by one g/L after controlling for confounding factors. In addition, the trend test and propensity score matching also showed a stable linear correlation between albumin level and preoperative DVT. Conclusion Serum albumin is associated with preoperative DVT in geriatric patients with hip fractures, and it could be considered a predictor for the risk of DVT. Registration ID ChiCTR2200057323.

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Osteoporotic hip fracture mortality and associated factors in Hawai’i

Cited by 12 publications

References 39 publications

The Influence of Body Fat Content and Distribution on Bone Mass in Healthy Chinese Adults

The Influence of Body Fat Content and Distribution on Bone Mass in Healthy Chinese Adults

Nontuberculous mycobacterial skin and soft tissue infection in Hawaiʻi

The association between admission serum albumin and preoperative deep venous thrombosis in geriatrics hip fracture: a retrospective study of 1819 patients with age ≥ 65 years

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