2005
DOI: 10.1080/08860220500198698
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Osteoprotegerin and Bone Mineral Density in Hemodiafiltration Patients

Abstract: A newly identified cytokine, osteoprotegerin (OPG) appears to be involved in the regulation of bone remodeling. In vitro studies suggest that OPG, a soluble member of the TNF receptor family of proteins, inhibits osteoclastogenesis by interrupting the intercellular signaling between osteoblastic stromal cells and osteoclast progenitors. As patients with chronic renal failure (CRF) often have renal osteodystrophy (ROD), we investigated the role of osteoprotegerin (OPG) in ROD, and investigated whether there was… Show more

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Cited by 19 publications
(8 citation statements)
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“…Interestingly, the HIV-infected patients with VFs reported a lower value of SI in comparison with HIV-infected patients without VFs; this result is consistent with previous data on the role of quantitative ultrasound in the detection of bone fragility. Quantitative ultrasound is able to reflect different physical properties of bone (e.g., the density, elasticity, and microarchitecture) and provide information on fracture risk [ 25 , 26 , 27 , 28 , 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the HIV-infected patients with VFs reported a lower value of SI in comparison with HIV-infected patients without VFs; this result is consistent with previous data on the role of quantitative ultrasound in the detection of bone fragility. Quantitative ultrasound is able to reflect different physical properties of bone (e.g., the density, elasticity, and microarchitecture) and provide information on fracture risk [ 25 , 26 , 27 , 28 , 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Higher serum OPG and lower serum RANKL were found in CKD patients in hemodialysis. Increased serum OPG levels in hemodialysis patients are believed to partly reflect a compensatory response to increased bone loss (53). The determination of serum OPG levels in association with PTH levels could be useful in the diagnosis of bone turnover in renal patients (24).…”
Section: Discussionmentioning
confidence: 99%
“…Figure 1 shows the average values of BMD in studies of patients with CKD Stage 5D 4–6,12,13,16,29–76 . These values are expressed as Z ‐scores, which compare BMD in the patients with the BMD from the reference values of age‐ and gender‐matched persons in the community.…”
Section: Bone Density Measurements In Patients Receiving Haemodialysismentioning
confidence: 99%