Osteoprotegerin as a marker of cardiovascular risk in children and adolescents with type 1 diabetes

Fekih, O.; Triki, Hamdi; Triki, Smaı̈l; Neffati, Fadoua; Chouchane, S.; Guédiche, M.N.; Najjar, Mohamed Fadhel

doi:10.1111/pedi.12379

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…Together, these findings confirm that OPG levels are abnormal in adult TS cohorts, in particular those who have underlying aortic dilatation. However, contrary to the study by Fekih et al (45), OPG levels did not correlate with traditional cardiometabolic factors like hypertension, hsCRP, cholesterol levels, or nocturnal hypertension, all of which are associated with TS. Nonetheless, it suggests that OPG levels are a biomarker worth examining in childhood TS in relation to cardiometabolic risk factors and aortic disease.…”

Section: Opg In Tscontrasting

confidence: 99%

“…Fekih et al (45) quantified circulating OPG levels in a childhood T1DM cohort ( n = 143; mean age 12 years) with cardiometabolic risk factors such as prolonged duration (≥4 years) of diabetes, HbA1c ≥ 7%, dyslipidemia, and microalbuminuria (≥30 mg/24 h). Their study revealed that OPG levels were significantly higher ( p < 0.0001) in the T1DM cohort.…”

Section: Opg In Tsmentioning

confidence: 99%

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Can Brain Natriuretic Peptides and Osteoprotegerin Serve As Biochemical Markers for the Detection of Aortic Pathology in Children and Adolescents with Turner Syndrome?

Mavinkurve

O’Gorman

2017

Front. Endocrinol.

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Turner syndrome (TS) is a chromosomal disorder that affects 1:2,000 females. It results from either the complete or partial loss of the X chromosome as well as other aberrations. Clinical features of TS include short stature, delayed puberty, and congenital cardiac malformations. TS children also have an increased prevalence of cardiometabolic risk factors, which predisposes them to complications like coronary artery disease, cerebrovascular-related deaths, and aortic dissection. Early cardiac imaging, such as echocardiography and cardiac magnetic resonance imaging, are recommended to detect underlying aortic pathology. However, these modalities are limited by cost, accessibility, and are operator dependent. In view of these shortcomings, alternative methods, like vascular biomarkers, are currently being explored. There are only a few studies that have examined the relationship between B-type natriuretic peptide (BNP), N-terminal pro BNP (NT pro-BNP), and osteoprotegerin (OPG) and aortic disease in TS, and thus the data are only in proof-of-concept stages. Further meticulous longitudinal studies are required before BNP, NT pro-BNP, and OPG are used as vascular biomarkers for the detection of aortic disease in childhood and adolescent TS.

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Section: Opg In Tscontrasting

confidence: 99%

Section: Opg In Tsmentioning

confidence: 99%

Can Brain Natriuretic Peptides and Osteoprotegerin Serve As Biochemical Markers for the Detection of Aortic Pathology in Children and Adolescents with Turner Syndrome?

Mavinkurve

O’Gorman

2017

Front. Endocrinol.

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“…(41)(42)(43) Importantly, OPG has also been associated with cardiovascular risk, ulcer development, and peripheral neuropathies. (44)(45)(46)(47) The mechanism by which OPG contributes to these conditions may be through the inhibition of RANKL-induced angiogenesis, although OPG may also promote angiogenesis. (48,49) Because OPG did not change in response to the HEC, our results indicate that exogenous insulin does not acutely contribute to potential OPG-induced alterations in neurovascular function or bone turnover, but the source of increased OPG in T1D would need to be isolated to better inform its potential role in T1D-related complications.…”

Section: Discussionmentioning

confidence: 99%

Acute Hyperinsulinemia Alters Bone Turnover in Women and Men With Type 1 Diabetes

et al. 2020

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Type 1 diabetes (T1D) increases fracture risk across the lifespan. The low bone turnover associated with T1D is thought to be related to glycemic control, but it is unclear whether peripheral hyperinsulinemia due to dependence on exogenous insulin has an independent effect on suppressing bone turnover. The purpose of this study was to test the bone turnover marker (BTM) response to acute hyperinsulinemia. Fifty‐eight adults aged 18 to 65 years with T1D over 2 years were enrolled at seven T1D Exchange Clinic Network sites. Participants had T1D diagnosis between age 6 months to 45 years. Participants were stratified based on their residual endogenous insulin secretion measured as peak C‐peptide response to a mixed meal tolerance test. BTMs (CTX, P1NP, sclerostin [SCL], osteonectin [ON], alkaline phosphatase [ALP], osteocalcin [OCN], osteoprotegerin [OPG], osteopontin [OPN], and IGF‐1) were assessed before and at the end of a 2‐hour hyperinsulinemic‐euglycemic clamp (HEC). Baseline ON (r = −0.30, p = .022) and OCN (r = −0.41, p = .002) were negatively correlated with age at T1D diagnosis, but baseline BTMs were not associated with HbA1c. During the HEC, P1NP decreased significantly (−14.5 ± 44.3%; p = .020) from baseline. OCN, ON, and IGF‐1 all significantly increased (16.0 ± 13.1%, 29.7 ± 31.7%, 34.1 ± 71.2%, respectively; all p < .001) during the clamp. The increase in SCL was not significant (7.3 ± 32.9%, p = .098), but the decrease in CTX (−12.4 ± 48.9, p = .058) neared significance. ALP and OPG were not changed from baseline (p = .23 and p = .77, respectively). Baseline ON and SCL were higher in men, but OPG was higher in women (all p ≤ .029). SCL was the only BTM that changed differently in women than men. There were no differences in baseline BTMs or change in BTMs between C‐peptide groups. Exogenous hyperinsulinemia acutely alters bone turnover, suggesting a need to determine whether strategies to promote healthy remodeling may protect bone quality in T1D. © 2020 American Society for Bone and Mineral Research © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

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Energy metabolism in bone tumors

Bonnelye

2022

Bone Cancer

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Osteoprotegerin as a marker of cardiovascular risk in children and adolescents with type 1 diabetes

Abstract: OPG may be a potential biomarker of cardiovascular risk in T1D. Implementation of OPG determination in the clinical laboratory setting would be useful in order to better stratify patients and to assess the most adequate treatment.

Cited by 7 publications

References 35 publications

Can Brain Natriuretic Peptides and Osteoprotegerin Serve As Biochemical Markers for the Detection of Aortic Pathology in Children and Adolescents with Turner Syndrome?

Can Brain Natriuretic Peptides and Osteoprotegerin Serve As Biochemical Markers for the Detection of Aortic Pathology in Children and Adolescents with Turner Syndrome?

Acute Hyperinsulinemia Alters Bone Turnover in Women and Men With Type 1 Diabetes

Energy metabolism in bone tumors

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