Osteoprotegerin in Human Milk: A Potential Role in the Regulation of Bone Metabolism and Immune Development

Vidal, Karine; Broek, P. van den; Lorget, Florence; Donnet-Hughes, Anne

doi:10.1203/01.pdr.0000127014.22068.15

Cited by 37 publications

(31 citation statements)

References 38 publications

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“…Our results differ from others as regards lysozyme, lactoferrin and OPG. 7,13,14,19 We found that vaginal delivery was associated with an increase in breast milk b-EP, 3 which may be relevant for postnatal adaptation because of its functional activity as an opioid neurotransmitter and immunomodulator. 3 Our findings of an association between higher concentrations of adiponectin in PBM and milk from nulliparous mothers are new.…”

Section: Discussionmentioning

confidence: 74%

“…[1][2][3][4] Among the breast milk bioactive proteins are secretory immunoglobulin A (sIgA), lysozyme, lactoferrin, osteoprotegerin (OPG), leptin, adiponectin and b-endorphin (b-EP) that have anti-infective, immune 5,6 and/or neuroendocrine properties. [7][8][9] It has been suggested that preterm delivery may affect the concentration of some of these bioactive breast milk proteins. 3,10 -12 As compared to term breast milk (TBM), preterm breast milk (PBM) is reported to have higher sIgA, 12 higher 13 or similar 14 lactoferrin, comparable lysozyme, 13,14 OPG 7 and b-EP, 3 and lower leptin 10 levels.…”

Section: Introductionmentioning

confidence: 99%

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Biologically active breast milk proteins in association with very preterm delivery and stage of lactation

Mehta

Petrová

2010

J Perinatol

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Objective: The aim of this study was to identify the independent effect of very preterm gestation on breast milk content of biologically active proteins (secretory immunoglobulin A (sIgA), lysozyme, lactoferrin, osteoprotegerin (OPG), leptin, adiponectin and b-endorphin (b-EP)) during the first month of lactation.Study Design: We collected samples of transitional (6 to 8 and 13 to 15 days) and mature (20 to 22 and 27 to 29 days) milk from mothers after term (38 to 41 weeks) or very preterm (24 to 31 weeks) delivery. The levels of sIgA, lysozyme, lactoferrin, OPG, leptin, adiponectin and b-EP in the breast milk were quantified using enzyme-linked immunosorbent assay or enzyme immunoassay kits. Statistical analysis included descriptive statistics and regression analysis.Result: Sixty breast milk samples were collected from 15 mothers after very preterm (preterm breast milk, PBM) and 20 samples from 5 mothers after term (term breast milk, TBM) deliveries. Decrease in lysozyme, lactoferrin, OPG, leptin, adiponectin and b-EP but no change in sIgA was recorded during the first month of lactation in both TBM and PBM. The IgA, lysozyme and adiponectin were higher in PBM than in TBM, whereas concentrations of lactoferrin, OPG and leptin were higher in TBM than in PBM (P<0.05 to 0.0001). A similar pattern was seen in the lysozyme, leptin and adiponectin concentration in mature milk. Increased b-EP levels in breast milk were associated with the vaginal mode of delivery but not gestational age. Conclusion:Although a similar pattern of change was observed in the breast milk bioactive proteins during the first month of lactation after term and very preterm gestation, PBM is a better source of factors with antibacterial/anti-inflammatory activities but is constantly deficient in leptin, which is involved in neuroendocrine regulation.

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Biologically active breast milk proteins in association with very preterm delivery and stage of lactation

Mehta

Petrová

2010

J Perinatol

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“…OPG is produced by numerous cell types, such as osteoblasts, DCs, and B cells, and its expression is up-regulated upon CD40 ligation (16). OPG is present as a secreted factor in serum, and has also recently been detected in human milk (17). Importantly, OPG has been suggested to function as a crucial regulator not only of bone metabolism, but also of B cell and DC function (18).…”

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confidence: 99%

Elevated Serum Levels of the Decoy Receptor Osteoprotegerin in Children with Langerhans Cell Histiocytosis

et al. 2006

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Langerhans cell histiocytosis (LCH) is characterized by an accumulation of dendritic Langerhans cells in granulomatous lesions in the bone, skin, and other sites in the body. The pathogenesis of the disease remains unknown. We measured serum levels of the decoy receptor osteoprotegerin (OPG), an important regulator of bone metabolism as well as immune responses, in 18 children with single system (SS) or multi-system (MS) forms of LCH and 20 pediatric controls. OPG levels were significantly increased in LCH patients at diagnosis when compared with controls, and pretreatment levels of OPG were elevated in MS compared with SS patients. Moreover, OPG levels in LCH patients were elevated in patients with involvement of risk organs (liver, lungs, hematopoietic system, or spleen) when compared with patients without risk organ involvement, indicative of an association between OPG values and disease severity. We also observed a positive correlation between serum levels of OPG and tumor necrosis factor (TNF)-␣, a proinflammatory cytokine, at the time of onset of disease. These findings show, for the first time, that serum OPG levels are elevated in LCH patients, and suggest that OPG may play a role in the pathogenesis of this enigmatic disease. (Pediatr Res 59: 281-286, 2006)

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“…Application thereof in osteopenia and osteoporosis conditions results in reduction of bone loss (32,35). They suppress induction of osteoclasts and stimulate proliferation of osteoblasts, which contributes to an increase in bone mineral density BMD (23,31).…”

Section: Praca Oryginalnamentioning

confidence: 99%

Densitometric, tomographic and mechanical parameters of the female Wistar rat skeletal system after lactoferrin and colostrum treatment in the condition of gonadectomy-induced osteopenia

Bieńko¹,

Wolski²,

Lis³

et al. 2016

Medycyna Weterynaryjna

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Osteoprotegerin in Human Milk: A Potential Role in the Regulation of Bone Metabolism and Immune Development

Cited by 37 publications

References 38 publications

Biologically active breast milk proteins in association with very preterm delivery and stage of lactation

Biologically active breast milk proteins in association with very preterm delivery and stage of lactation

Elevated Serum Levels of the Decoy Receptor Osteoprotegerin in Children with Langerhans Cell Histiocytosis

Densitometric, tomographic and mechanical parameters of the female Wistar rat skeletal system after lactoferrin and colostrum treatment in the condition of gonadectomy-induced osteopenia

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