Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences

Grisar, Koenraad; Schol, Matthias; Schoenaers, Joseph; Dormaar, Titiaan; Coropciuc, Ruxandra; Poorten, Vincent Vander; Politis, Constantinus

doi:10.1016/j.ijom.2016.06.016

Cited by 40 publications

(35 citation statements)

References 52 publications

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“…In the reports by Grisar et al [4] and Began et al [9], the age and ratio of female to male patients were significantly higher in MRONJ cases, which is similar to the results found in our study. Regarding the clinical symptoms, significantly more pathological fractures and skin fistulae occurred in ORN patients in their reports [4,9]. In our study, dietary change and trismus occurred significantly more frequently in ORN patients.…”

Section: Discussionsupporting

confidence: 93%

“…Although ORN and MRONJ may appear similar, clinically important differences between these diseases have been previously identified [4,8,9]. In the reports by Grisar et al [4] and Began et al [9], the age and ratio of female to male patients were significantly higher in MRONJ cases, which is similar to the results found in our study. Regarding the clinical symptoms, significantly more pathological fractures and skin fistulae occurred in ORN patients in their reports [4,9].…”

Section: Discussionsupporting

confidence: 91%

“…Both osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are problematic complications associated with the treatment of primary malignant tumours, metastatic lesions, and osteoporosis. The incidence of both diseases is low [1][2][3], but the number of patients with MRONJ continues to increase because of the implementation of new drugs [4]. The advancement of radiation therapy (RT) techniques (e.g., intensity-modulated radiation therapy [IMRT]) decreases the number of patients with ORN, but it has not eliminated this complication.…”

Section: Introductionmentioning

confidence: 99%

“…The appearance of ORN and MRONJ is similar (briefly, exposure of necrotic bone and infection of the surrounding soft tissue), but differences in patient factors, imaging findings, aetiology and pathogenesis have been identified [4,[8][9][10]. In general, conservative treatment such as antibiotic administration and local irrigation is recommended for early stage ORN and MRONJ.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw

Akashi

Wanifuchi

Iwata

et al. 2017

Oral Maxillofac Surg

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw

Akashi

Wanifuchi

Iwata

et al. 2017

Oral Maxillofac Surg

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“…Medication‐related osteonecrosis of the jaw (MRONJ, new nomenclature replacing bisphosphonate‐related osteonecrosis of the jaw [BRONJ]) is one of the major complications after tooth extraction in patients using bisphosphonates (BPs). Recent studies have focused more on the treatment of MRONJ than ORN because the incidence of MRONJ is significantly increasing and its treatment is more complicated than that for ORN (Grisar et al, ). In such cases, although bone graft materials can be used to rebuild the surgically removed necrotic bone, great care should be taken because the curative capacity of bone tissue that had undergone ORN or MRONJ is very low compared to that of normal tissue (Mericske‐Stern, Perren, & Raveh, ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of hyperbaric oxygen therapy with PTH [1–34] on calvarial bone graft in irradiated rat

Park

Choi

et al. 2019

Oral Diseases

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Objective:To determine the synergistic effect of parathyroid hormone (PTH) in combination with hyperbaric oxygen (HBO) on bone graft in a rat calvarial bone defect model under impaired osteogenic conditions. Materials and Methods:Twenty-four rats were divided into three groups. Localized radiation with a single 12 Gy dose was administered to the calvaria. Four weeks after radiation, calvarial circular defects were created in the parietal bones. All defects were filled with biphasic calcium phosphate. After the bone graft, PTH [1-34] was injected subcutaneously, and HBO was administered. At 6 weeks after the bone graft, the rats were sacrificed, and specimens were harvested.Results: Histomorphometric evaluation showed that the percentage of new bone area was higher in the PTH and PTH/HBO groups than in the control group. The percent residual material area was decreased in the PTH/HBO group compared with the control group. The percentage blood vessel number was highest in the PTH group. Micro-CT evaluation showed that the new bone volume was highest in the PTH/HBO group. The residual material volume was lowest in the PTH/HBO group. Conclusion:Within the limitations of this study, our data indicate that PTH combined with HBO may reverse radiation-induced impairment of bone healing. K E Y W O R D Sanimal model, bone graft, bone regeneration, calvarial defect, hyperbaric oxygen therapy, parathyroid hormone

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Treatment of medication‐related osteonecrosis of the jaw using segmental mandibulectomy and a reconstruction plate: A case report and 5‐year follow‐up

Kamaguchi

Ohga

Hata

et al. 2021

Oral Science International

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Bisphosphonates (BPs) are antiresorptive agents that are widely used in the prevention and treatment of osteoporosis, Paget's disease, multiple myeloma, and bone metastasis of solid tumors. [1][2][3][4] As BPs effectively reduce osteoporosis-related bone fractures, they are used as a first-line therapy for the treatment of the primary osteoporosis. 5 Despite the therapeutic benefits of BPs, antiresorptive or antiangiogenic agents are associated with medication-related osteonecrosis of the jaw (MRONJ). 6 Systemic risk factors for MRONJ include duration of exposure to antiresorptive agents, age, use of corticosteroids, presence of comorbidities, and smoking, 7,8 whereas local risk factors include invasive dental treatments such as tooth extractions, uncontrolled periodontitis, inappropriate denture use, and poor oral hygiene. 9-11 Moreover, the management of bone metastasis by intravenous administration of high-dose BPs has been reported to

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Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences

Cited by 40 publications

References 52 publications

Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw

Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw

Synergistic effect of hyperbaric oxygen therapy with PTH [1–34] on calvarial bone graft in irradiated rat

Treatment of medication‐related osteonecrosis of the jaw using segmental mandibulectomy and a reconstruction plate: A case report and 5‐year follow‐up

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