1992
DOI: 10.2106/00004623-199274070-00015
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Osteosarcoma as a second malignant neoplasm in children.

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Cited by 42 publications
(27 citation statements)
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“…The development of postirradiation sarcoma is probably multifactorial, including genetic tendency [33][34][35][36][37][38][39][40][41], influence of chemotherapeutic agents [32], and unknown factors. Doses of irradiation as low as 1,945 to 3,000 cGy have been implicated [42][43][44]. The most common dose in the current series was between 40 and 60 Gy and is within the range most commonly reported in other series [13,17,25,43,44].…”
Section: Discussionsupporting
confidence: 58%
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“…The development of postirradiation sarcoma is probably multifactorial, including genetic tendency [33][34][35][36][37][38][39][40][41], influence of chemotherapeutic agents [32], and unknown factors. Doses of irradiation as low as 1,945 to 3,000 cGy have been implicated [42][43][44]. The most common dose in the current series was between 40 and 60 Gy and is within the range most commonly reported in other series [13,17,25,43,44].…”
Section: Discussionsupporting
confidence: 58%
“…Doses of irradiation as low as 1,945 to 3,000 cGy have been implicated [42][43][44]. The most common dose in the current series was between 40 and 60 Gy and is within the range most commonly reported in other series [13,17,25,43,44].…”
Section: Discussionsupporting
confidence: 58%
See 1 more Smart Citation
“…The prevalence of secondary osteosarcoma in patients who survived for 5 years after radiation of a primary malignant tumor with 4000-7000 cGy is reported to be between 0.05 and 0.2 % [16]. Osteosarcoma occurs between 10 and 20 years after initial irradiation, with the risk increasing as the radiation dose increases° There are only a few reports of osteosarcoma developing after treatment of neuroblastoma [12,14]. In one case the patient was treated with 2300 cGy local irradiation after surgery; the osteosarcoma was located in the ilium, and the latent period was 21 years and 9 months.…”
Section: Discussionmentioning
confidence: 99%
“…There have been only a few reports [12,14] of osteosarcoma or chondrosarcoma as a second malignancy following treatment of childhood neuroblastoma. These patients received localized radiation to the tumor bed and/or chemotherapy.…”
Section: Introductionmentioning
confidence: 99%