Abstract:Osteosarcoma (OS) is the most common primary malignant bone tumour that typically occurs in adolescents and young adults. OS incidence has been related to growth and height, age, gender, ethnicity, certain inherited cancer predisposition syndromes, abnormal bone growth and therapeutic radiation. However, most cases are sporadic (not associated with an inherited syndrome) and no specific genetic or environmental predisposing factor has been identified. A common genetic susceptibility locus has not been found.
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