2010
DOI: 10.1007/s00432-010-0923-7
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Osteosarcoma: improvement in survival limited to high-grade patients only

Abstract: The level of evidence for this article is 2.

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Cited by 91 publications
(80 citation statements)
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“…With advances in the medical management of musculoskeletal malignancies, patient survival has improved substantially [11]. Thus, specific means to address aseptic failure, the primary cause of EPR failure at intermediate to long term, are needed.…”
Section: Introductionmentioning
confidence: 99%
“…With advances in the medical management of musculoskeletal malignancies, patient survival has improved substantially [11]. Thus, specific means to address aseptic failure, the primary cause of EPR failure at intermediate to long term, are needed.…”
Section: Introductionmentioning
confidence: 99%
“…However, the OR estimates for an age of sixty years or more (OR = 2.04; 95% CI, 1.53 to 2.73), an axial tumor location (OR = 2.10; 95% CI, 1.56 to 2.84), and a low composite SES score (OR = 1.62; 95% CI, 1.08 to 2.42) were similar to those in the analysis that eliminated cases with missing tumor size information. It has been demonstrated previously, and it is well accepted, that patients with metastatic disease at initial presentation have a poorer prognosis than those with localized disease [3][4][5][6][7][8][9][10] . Bacci et al reported an overall survival rate of 94% at two years for osteosarcoma patients with localized disease compared with 55% for those with metastatic disease at presentation 4 .…”
mentioning
confidence: 97%
“…Many previous studies have revealed an association of increasing age with a poorer prognosis in patients with osteosarcoma [5][6][7]10,16,17 . However, there is substantial uncertainty and debate regarding whether age itself is a risk factor or is simply a surrogate for other, more important, aspects of the disease.…”
mentioning
confidence: 99%
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“…effective chemotherapy, the five-year survival rate for patients treated with intensive multidrug chemotherapy and aggressive local control has been reported at 55-80% (3,20,21). However, chemotherapy may fail to eliminate all osteosarcoma cells due to intrinsic or acquired drug resistance, which is the most frequent cause of tumor recurrence and results in a poor clinical outcome (22).…”
mentioning
confidence: 99%